Summary: This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010].

activin A receptor type 1BMIM:601300Ensembl:ENSG00000135503HGNC:HGNC:172PA2449312q13.13

GO terms in ACVR1B

Term TypeEvidence TypeGO Term IDGO Des.
MFEXPGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFNASGO:0004675transmembrane receptor protein serine/threonine kinase activity
MFIBAGO:0005024transforming growth factor beta-activated receptor activity
MFIBAGO:0005025transforming growth factor beta receptor activity, type I
MFIPIGO:0005515protein binding
MFIDAGO:0005524ATP binding
MFIDAGO:0016361activin receptor activity, type I
MFTASGO:0016361activin receptor activity, type I
MFIDAGO:0017002activin-activated receptor activity
MFIBAGO:0019838growth factor binding
MFIPIGO:0019838growth factor binding
MFNASGO:0031625ubiquitin protein ligase binding
MFIPIGO:0034711inhibin binding
MFIBAGO:0046332SMAD binding
MFIDAGO:0046332SMAD binding
MFIEAGO:0046872metal ion binding
MFIBAGO:0048185activin binding
MFIBAGO:0048185activin binding
MFIDAGO:0048185activin binding
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCIDAGO:0005887integral component of plasma membrane
CCIDAGO:0009986cell surface
CCIBAGO:0043235receptor complex
CCIDAGO:0043235receptor complex
CCIBAGO:0048179activin receptor complex
CCIDAGO:0048179activin receptor complex
BPIDAGO:0000082G1/S transition of mitotic cell cycle
BPIEAGO:0001701in utero embryonic development
BPIEAGO:0001942hair follicle development
BPIDAGO:0006355regulation of transcription, DNA-templated
BPIDAGO:0006468protein phosphorylation
BPIDAGO:0007165signal transduction
BPTASGO:0007178transmembrane receptor protein serine/threonine kinase signaling pathway
BPIBAGO:0007179transforming growth factor beta receptor signaling pathway
BPIBAGO:0007389pattern specification process
BPIEAGO:0007417central nervous system development
BPIEAGO:0010629negative regulation of gene expression
BPIEAGO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation
BPIDAGO:0018107peptidyl-threonine phosphorylation
BPIDAGO:0030308negative regulation of cell growth
BPIBAGO:0032924activin receptor signaling pathway
BPIDAGO:0032924activin receptor signaling pathway
BPIMPGO:0032924activin receptor signaling pathway
BPIDAGO:0032927positive regulation of activin receptor signaling pathway
BPIGIGO:0038092nodal signaling pathway
BPIDAGO:0045648positive regulation of erythrocyte differentiation
BPIEAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0046545development of primary female sexual characteristics
BPIDAGO:0046777protein autophosphorylation
BPIMPGO:0097191extrinsic apoptotic signaling pathway
BPIDAGO:1901165positive regulation of trophoblast cell migration

Gene expression in normal tissue: ACVR1B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ACVR1B

DatabasePathway IDPathway Des.
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04350TGF-beta signaling pathway - Homo sapiens (human)
kegghsa04550Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP2849Hematopoietic Stem Cell Differentiation
reactomeR-HSA-1181150Signaling by NODAL
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1433617Regulation of signaling by NODAL
reactomeR-HSA-1502540Signaling by Activin
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-9006936Signaling by TGF-beta family members

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD61Kinetin riboside2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ACVR1B