ACVR1B


Summary: This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:601300
PHARMGKB IDPA24493
Map Location12q13.13

GO terms in ACVR1B


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Term Type
Evidence Type
GO Term ID
GO Des.
MF EXP GO:0004674 protein serine/threonine kinase activity
MF IDA GO:0004674 protein serine/threonine kinase activity
MF TAS GO:0004674 protein serine/threonine kinase activity
MF NAS GO:0004675 transmembrane receptor protein serine/threonine kinase activity
MF IBA GO:0005024 transforming growth factor beta-activated receptor activity
MF IBA GO:0005025 transforming growth factor beta receptor activity, type I
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Gene expression in normal tissue: ACVR1B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ACVR1B


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Database
Pathway ID
Pathway Des.
kegg hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegg hsa04350 TGF-beta signaling pathway - Homo sapiens (human)
kegg hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
wikipathways WP2005 miR-targeted genes in muscle cell - TarBase
wikipathways WP2849 Hematopoietic Stem Cell Differentiation
reactome R-HSA-1181150 Signaling by NODAL
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD524 ISX-9 1
iGMDRD945 ML214 3
iGMDRD634 SCHEMBL2608041 1
iGMDRD61 Kinetin riboside 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ACVR1B

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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