CDC34


Summary: The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
cell division cycle 34MIM:116948Ensembl:ENSG00000099804HGNC:HGNC:1734PA2626519p13.3

GO terms in CDC34


Term TypeEvidence TypeGO Term IDGO Des.
CCNASGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0016607nuclear speck
BPNASGO:0000082G1/S transition of mitotic cell cycle
BPIBAGO:0000209protein polyubiquitination
BPIDAGO:0000209protein polyubiquitination
BPNASGO:0006270DNA replication initiation
BPNASGO:0006464cellular protein modification process
BPIBAGO:0006511ubiquitin-dependent protein catabolic process
BPIDAGO:0016567protein ubiquitination
BPNASGO:0016567protein ubiquitination
BPTASGO:0016567protein ubiquitination
BPIMPGO:0035458cellular response to interferon-beta
BPIBAGO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process
BPIDAGO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process
BPIEAGO:0043525positive regulation of neuron apoptotic process
BPIDAGO:0043951negative regulation of cAMP-mediated signaling
BPIEAGO:0070848response to growth factor
BPIDAGO:0070936protein K48-linked ubiquitination
BPIEAGO:0090261positive regulation of inclusion body assembly
MFIDAGO:0004842ubiquitin-protein transferase activity
MFNASGO:0004842ubiquitin-protein transferase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIBAGO:0061631ubiquitin conjugating enzyme activity
MFIDAGO:0061631ubiquitin conjugating enzyme activity

Gene expression in normal tissue: CDC34

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CDC34


DatabasePathway IDPathway Des.
biocartafbw7pathwaycyclin e destruction pathway
biocartaskp2e2fpathwaye2f1 destruction pathway
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-202403TCR signaling
reactomeR-HSA-202424Downstream TCR signaling
reactomeR-HSA-2454202Fc epsilon receptor (FCERI) signaling
reactomeR-HSA-2871837FCERI mediated NF-kB activation
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5607764CLEC7A (Dectin-1) signaling
reactomeR-HSA-5621481C-type lectin receptors (CLRs)
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-8852135Protein ubiquitination
reactomeR-HSA-8866652Synthesis of active ubiquitin: roles of E1 and E2 enzymes
reactomeR-HSA-983168Antigen processing: Ubiquitination & Proteasome degradation
reactomeR-HSA-983169Class I MHC mediated antigen processing & presentation
wikipathwaysWP2877Vitamin D Receptor Pathway
humancycPWY-7511protein ubiquitylation
netpathPathway_TNFalphaTNFalpha
kegghsa04120Ubiquitin mediated proteolysis - Homo sapiens (human)
kegghsa05168Herpes simplex infection - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD79Gemcitabine3
iGMDRD781Sirolimus3
iGMDRD554CHEMBL14341373
iGMDRD126Tipifarnib3
iGMDRD154NSC237663
iGMDRD679Bistramide A2
iGMDRD297Austocystin D3
iGMDRD318PAC-13
iGMDRD434BMS-5369243
iGMDRD255SB2250023
iGMDRD64Parbendazole3
iGMDRD562Navitoclax9
iGMDRD366PI-1032
iGMDRD506Fedratinib3
iGMDRD577BIX012943
iGMDRD887Compound 23 citrate3
iGMDRD871BRD63683
iGMDRD188Piperlongumine3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CDC34

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