CDC34
Summary: The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cell division cycle 34 | MIM:116948 | Ensembl:ENSG00000099804 | HGNC:HGNC:1734 | PA26265 | 19p13.3 |
GO terms in CDC34
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | NAS | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0016607 | nuclear speck |
| BP | NAS | GO:0000082 | G1/S transition of mitotic cell cycle |
| BP | IBA | GO:0000209 | protein polyubiquitination |
| BP | IDA | GO:0000209 | protein polyubiquitination |
| BP | NAS | GO:0006270 | DNA replication initiation |
| BP | NAS | GO:0006464 | cellular protein modification process |
| BP | IBA | GO:0006511 | ubiquitin-dependent protein catabolic process |
| BP | IDA | GO:0016567 | protein ubiquitination |
| BP | NAS | GO:0016567 | protein ubiquitination |
| BP | TAS | GO:0016567 | protein ubiquitination |
| BP | IMP | GO:0035458 | cellular response to interferon-beta |
| BP | IBA | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| BP | IDA | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| BP | IEA | GO:0043525 | positive regulation of neuron apoptotic process |
| BP | IDA | GO:0043951 | negative regulation of cAMP-mediated signaling |
| BP | IEA | GO:0070848 | response to growth factor |
| BP | IDA | GO:0070936 | protein K48-linked ubiquitination |
| BP | IEA | GO:0090261 | positive regulation of inclusion body assembly |
| MF | IDA | GO:0004842 | ubiquitin-protein transferase activity |
| MF | NAS | GO:0004842 | ubiquitin-protein transferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0061631 | ubiquitin conjugating enzyme activity |
| MF | IDA | GO:0061631 | ubiquitin conjugating enzyme activity |
Gene expression in normal tissue: CDC34
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDC34
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | fbw7pathway | cyclin e destruction pathway |
| biocarta | skp2e2fpathway | e2f1 destruction pathway |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-202403 | TCR signaling |
| reactome | R-HSA-202424 | Downstream TCR signaling |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2871837 | FCERI mediated NF-kB activation |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5607764 | CLEC7A (Dectin-1) signaling |
| reactome | R-HSA-5621481 | C-type lectin receptors (CLRs) |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-8852135 | Protein ubiquitination |
| reactome | R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes |
| reactome | R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| humancyc | PWY-7511 | protein ubiquitylation |
| netpath | Pathway_TNFalpha | TNFalpha |
| kegg | hsa04120 | Ubiquitin mediated proteolysis - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD554 | CHEMBL1434137 | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD562 | Navitoclax | 9 |
| iGMDRD366 | PI-103 | 2 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD188 | Piperlongumine | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDC34
CLASSFICATION
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