CDC34

Summary: The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namecell division cycle 34
OMIM IDMIM:116948
Ensembl IDEnsembl:ENSG00000099804
HGNC IDHGNC:HGNC:1734
PHARMGKB IDPA26265
Map Location19p13.3

GO terms in CDC34


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Term Type
Evidence Type
GO Term ID
GO Des.
CC NAS GO:0005634 nucleus
CC TAS GO:0005654 nucleoplasm
CC IDA GO:0005829 cytosol
CC TAS GO:0005829 cytosol
CC IDA GO:0016607 nuclear speck
BP NAS GO:0000082 G1/S transition of mitotic cell cycle
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Gene expression in normal tissue: CDC34

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CDC34


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Database
Pathway ID
Pathway Des.
biocarta fbw7pathway cyclin e destruction pathway
biocarta skp2e2fpathway e2f1 destruction pathway
reactome R-HSA-1280218 Adaptive Immune System
reactome R-HSA-168249 Innate Immune System
reactome R-HSA-168256 Immune System
reactome R-HSA-202403 TCR signaling
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD79 Gemcitabine 3
iGMDRD781 Sirolimus 3
iGMDRD554 CHEMBL1434137 3
iGMDRD126 Tipifarnib 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CDC34

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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