MYD88

Summary: This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameMYD88, innate immune signal transduction adaptor
OMIM IDMIM:602170
Ensembl IDEnsembl:ENSG00000172936
HGNC IDHGNC:HGNC:7562
PHARMGKB IDPA31361
Map Location3p22.2

Gene Categories:

CLINICALLY ACTIONABLE

GO terms in MYD88


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Term Type
Evidence Type
GO Term ID
GO Des.
BP TAS GO:0002224 toll-like receptor signaling pathway
BP TAS GO:0002755 MyD88-dependent toll-like receptor signaling pathway
BP IMP GO:0006915 apoptotic process
BP IEA GO:0006954 inflammatory response
BP NAS GO:0007165 signal transduction
BP TAS GO:0007166 cell surface receptor signaling pathway
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Gene expression in normal tissue: MYD88

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 8undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 21undefinedtissue: undefined cancer: Lymphoma model num: 2BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 10UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 3LYMPtissue: LYMP cancer: LYMPH model num: 0LYMPHtissue: LYMPH cancer: Waldenstrom Macroglobulinemia (WM) model num: 3BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: Breast Carcinoma model num: 1

Gene-drug pathway distribution

undefined15Metabolism1Apoptosis regulation1Chromatin histone acetylation1Metabolic pathways1PI3K/MTOR signaling1

Pathways in MYD88


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Database
Pathway ID
Pathway Des.
wikipathways WP1449 Regulation of toll-like receptor signaling pathway
wikipathways WP1772 Apoptosis Modulation and Signaling
wikipathways WP195 IL-1 signaling pathway
wikipathways WP2324 AGE-RAGE pathway
wikipathways WP2512 Integrated Lung Cancer Pathway
wikipathways WP2637 Structural Pathway of Interleukin 1 (IL-1)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD255 SB225002 3
iGMDRD870 BRD63610 3
iGMDRD68 Paclitaxel 1
iGMDRD434 BMS-536924 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MYD88

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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