MYD88
Summary: This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| MYD88, innate immune signal transduction adaptor | MIM:602170 | Ensembl:ENSG00000172936 | HGNC:HGNC:7562 | PA31361 | 3p22.2 |
Gene Categories:
CLINICALLY ACTIONABLEGO terms in MYD88
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0002224 | toll-like receptor signaling pathway |
| BP | TAS | GO:0002755 | MyD88-dependent toll-like receptor signaling pathway |
| BP | IMP | GO:0006915 | apoptotic process |
| BP | IEA | GO:0006954 | inflammatory response |
| BP | NAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007166 | cell surface receptor signaling pathway |
| BP | ISS | GO:0010628 | positive regulation of gene expression |
| BP | IMP | GO:0032481 | positive regulation of type I interferon production |
| BP | TAS | GO:0032481 | positive regulation of type I interferon production |
| BP | ISS | GO:0032740 | positive regulation of interleukin-17 production |
| BP | ISS | GO:0032747 | positive regulation of interleukin-23 production |
| BP | ISS | GO:0032755 | positive regulation of interleukin-6 production |
| BP | TAS | GO:0034162 | toll-like receptor 9 signaling pathway |
| BP | TAS | GO:0043066 | negative regulation of apoptotic process |
| BP | IEP | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | ISS | GO:0050727 | regulation of inflammatory response |
| BP | ISS | GO:0050830 | defense response to Gram-positive bacterium |
| BP | IMP | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IMP | GO:0060337 | type I interferon signaling pathway |
| BP | TAS | GO:0070498 | interleukin-1-mediated signaling pathway |
| BP | IMP | GO:0070555 | response to interleukin-1 |
| BP | IDA | GO:0070935 | 3'-UTR-mediated mRNA stabilization |
| BP | IEP | GO:0071260 | cellular response to mechanical stimulus |
| BP | ISS | GO:0140052 | cellular response to oxidised low-density lipoprotein particle stimulus |
| BP | ISS | GO:1900017 | positive regulation of cytokine production involved in inflammatory response |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0010008 | endosome membrane |
| MF | TAS | GO:0005123 | death receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IDA | GO:0043621 | protein self-association |
| MF | IPI | GO:0070976 | TIR domain binding |
Gene expression in normal tissue: MYD88
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MYD88
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP195 | IL-1 signaling pathway |
| wikipathways | WP2324 | AGE-RAGE pathway |
| wikipathways | WP2512 | Integrated Lung Cancer Pathway |
| wikipathways | WP2637 | Structural Pathway of Interleukin 1 (IL-1) |
| wikipathways | WP2865 | IL1 and megakaryocytes in obesity |
| wikipathways | WP3851 | TLR4 Signaling and Tolerance |
| wikipathways | WP3858 | Toll-like Receptor Signaling |
| wikipathways | WP3877 | Simplified Depiction of MYD88 Distinct Input-Output Pathway |
| wikipathways | WP4136 | Fibrin Complement Receptor 3 Signaling Pathway |
| wikipathways | WP75 | Toll-like Receptor Signaling Pathway |
| pid | il1pathway | IL1-mediated signaling events |
| pid | p75ntrpathway | p75(NTR)-mediated signaling |
| pid | toll_endogenous_pathway | Endogenous TLR signaling |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| kegg | hsa04620 | Toll-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa05132 | Salmonella infection - Homo sapiens (human) |
| kegg | hsa05133 | Pertussis - Homo sapiens (human) |
| kegg | hsa05134 | Legionellosis - Homo sapiens (human) |
| kegg | hsa05140 | Leishmaniasis - Homo sapiens (human) |
| kegg | hsa05142 | Chagas disease (American trypanosomiasis) - Homo sapiens (human) |
| kegg | hsa05143 | African trypanosomiasis - Homo sapiens (human) |
| kegg | hsa05144 | Malaria - Homo sapiens (human) |
| kegg | hsa05145 | Toxoplasmosis - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
| netpath | Pathway_IL1 | IL1 |
| netpath | Pathway_RAGE | RAGE |
| biocarta | gsk3pathway | inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages |
| biocarta | il1rpathway | signal transduction through il1r |
| biocarta | nfkbpathway | nf-kb signaling pathway |
| biocarta | nthipathway | nfkb activation by nontypeable hemophilus influenzae |
| biocarta | tollpathway | toll-like receptor pathway |
| reactome | R-HSA-1236974 | ER-Phagosome pathway |
| reactome | R-HSA-1236975 | Antigen processing-Cross presentation |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166058 | MyD88:Mal cascade initiated on plasma membrane |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade |
| reactome | R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade |
| reactome | R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade |
| reactome | R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| reactome | R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 |
| reactome | R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade |
| reactome | R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA |
| reactome | R-HSA-193639 | p75NTR signals via NF-kB |
| reactome | R-HSA-193639 | p75NTR signals via NF-kB |
| reactome | R-HSA-193704 | p75 NTR receptor-mediated signalling |
| reactome | R-HSA-193704 | p75 NTR receptor-mediated signalling |
| reactome | R-HSA-199418 | Negative regulation of the PI3K/AKT network |
| reactome | R-HSA-209543 | p75NTR recruits signalling complexes |
| reactome | R-HSA-209543 | p75NTR recruits signalling complexes |
| reactome | R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production |
| reactome | R-HSA-446652 | Interleukin-1 family signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-5260271 | Diseases of Immune System |
| reactome | R-HSA-5602358 | Diseases associated with the TLR signaling cascade |
| reactome | R-HSA-5602498 | MyD88 deficiency (TLR2/4) |
| reactome | R-HSA-5602680 | MyD88 deficiency (TLR5) |
| reactome | R-HSA-5603037 | IRAK4 deficiency (TLR5) |
| reactome | R-HSA-5603041 | IRAK4 deficiency (TLR2/4) |
| reactome | R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9020702 | Interleukin-1 signaling |
| reactome | R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| reactome | R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| reactome | R-HSA-975155 | MyD88 dependent cascade initiated on endosome |
| reactome | R-HSA-975871 | MyD88 cascade initiated on plasma membrane |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD255 | SB225002 | 3 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD68 | Paclitaxel | 1 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD366 | PI-103 | 3 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD932 | JAK inhibitor | 1 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD927 | IMGENEX | 1 |
| iGMDRD482 | IRAK-1/4 Inhibitor | 1 |
| iGMDRD549 | Ibrutinib (PCI-32765) | 2 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD466 | Chaetocin | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MYD88
CLASSFICATION
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