FURIN


Summary: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a role in tumor progression. This gene is located in close proximity to family member proprotein convertase subtilisin/kexin type 6 and upstream of the FES oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in FURIN


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0002020 protease binding
MF IDA GO:0004175 endopeptidase activity
MF TAS GO:0004175 endopeptidase activity
MF IDA GO:0004252 serine-type endopeptidase activity
MF IMP GO:0004252 serine-type endopeptidase activity
MF TAS GO:0004252 serine-type endopeptidase activity
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Gene expression in normal tissue: FURIN

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FURIN


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1181150 Signaling by NODAL
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-1442490 Collagen degradation
reactome R-HSA-1442490 Collagen degradation
reactome R-HSA-1474228 Degradation of the extracellular matrix
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD123 Isoevodiamine 3
iGMDRD945 ML214 1
iGMDRD446 LY 2183240 2
iGMDRD85 Ursolic acid 4
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FURIN

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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