FURIN
Summary: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a role in tumor progression. This gene is located in close proximity to family member proprotein convertase subtilisin/kexin type 6 and upstream of the FES oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:136950 Ensembl IDEnsembl:ENSG00000140564 HGNC IDHGNC:HGNC:8568 PHARMGKB IDPA32894 Map Location15q26.1 |
GO terms in FURIN
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IPI | GO:0002020 | protease binding |
MF | IDA | GO:0004175 | endopeptidase activity |
MF | TAS | GO:0004175 | endopeptidase activity |
MF | IDA | GO:0004252 | serine-type endopeptidase activity |
MF | IMP | GO:0004252 | serine-type endopeptidase activity |
MF | TAS | GO:0004252 | serine-type endopeptidase activity |
Gene expression in normal tissue: FURIN
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FURIN
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-1181150 | Signaling by NODAL |
reactome | R-HSA-1266738 | Developmental Biology |
reactome | R-HSA-1266738 | Developmental Biology |
reactome | R-HSA-1442490 | Collagen degradation |
reactome | R-HSA-1442490 | Collagen degradation |
reactome | R-HSA-1474228 | Degradation of the extracellular matrix |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in FURIN
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |