FURIN


Summary: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a role in tumor progression. This gene is located in close proximity to family member proprotein convertase subtilisin/kexin type 6 and upstream of the FES oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
furin, paired basic amino acid cleaving enzymeMIM:136950Ensembl:ENSG00000140564HGNC:HGNC:8568PA3289415q26.1

GO terms in FURIN


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0002020protease binding
MFIDAGO:0004175endopeptidase activity
MFTASGO:0004175endopeptidase activity
MFIDAGO:0004252serine-type endopeptidase activity
MFIMPGO:0004252serine-type endopeptidase activity
MFTASGO:0004252serine-type endopeptidase activity
MFIDAGO:0004867serine-type endopeptidase inhibitor activity
MFIPIGO:0005515protein binding
MFIDAGO:0008233peptidase activity
MFIDAGO:0042277peptide binding
MFIEAGO:0046872metal ion binding
MFIDAGO:0048406nerve growth factor binding
BPIDAGO:0006465signal peptide processing
BPTASGO:0006465signal peptide processing
BPTASGO:0007179transforming growth factor beta receptor signaling pathway
BPIMPGO:0008283cell proliferation
BPIEAGO:0009966regulation of signal transduction
BPIEAGO:0010951negative regulation of endopeptidase activity
BPIDAGO:0016485protein processing
BPIMPGO:0016485protein processing
BPIDAGO:0016486peptide hormone processing
BPIEPGO:0019058viral life cycle
BPTASGO:0019082viral protein processing
BPTASGO:0022617extracellular matrix disassembly
BPTASGO:0030198extracellular matrix organization
BPTASGO:0030574collagen catabolic process
BPIMPGO:0031638zymogen activation
BPIDAGO:0032804negative regulation of low-density lipoprotein particle receptor catabolic process
BPIDAGO:0032902nerve growth factor production
BPIDAGO:0032904negative regulation of nerve growth factor production
BPIMPGO:0032911negative regulation of transforming growth factor beta1 production
BPIDAGO:0032940secretion by cell
BPIMPGO:0042176regulation of protein catabolic process
BPIDAGO:0043043peptide biosynthetic process
BPTASGO:0044267cellular protein metabolic process
BPIEAGO:0045714regulation of low-density lipoprotein particle receptor biosynthetic process
BPTASGO:0051004regulation of lipoprotein lipase activity
BPICGO:0051044positive regulation of membrane protein ectodomain proteolysis
BPIDAGO:0052548regulation of endopeptidase activity
BPTASGO:0070268cornification
BPIMPGO:0090472dibasic protein processing
CCIMPGO:0000139Golgi membrane
CCTASGO:0000139Golgi membrane
CCTASGO:0005576extracellular region
CCIDAGO:0005615extracellular space
CCIGIGO:0005783endoplasmic reticulum
CCTASGO:0005796Golgi lumen
CCIDAGO:0005802trans-Golgi network
CCTASGO:0005886plasma membrane
CCIDAGO:0009986cell surface
CCIEAGO:0010008endosome membrane
CCHDAGO:0016020membrane
CCIEAGO:0016021integral component of membrane
CCIDAGO:0030140trans-Golgi network transport vesicle
CCIDAGO:0045121membrane raft
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: FURIN

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FURIN


DatabasePathway IDPathway Des.
reactomeR-HSA-1181150Signaling by NODAL
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1442490Collagen degradation
reactomeR-HSA-1442490Collagen degradation
reactomeR-HSA-1474228Degradation of the extracellular matrix
reactomeR-HSA-1474228Degradation of the extracellular matrix
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-1566948Elastic fibre formation
reactomeR-HSA-157118Signaling by NOTCH
reactomeR-HSA-1592389Activation of Matrix Metalloproteinases
reactomeR-HSA-159782Removal of aminoterminal propeptides from gamma-carboxylated proteins
reactomeR-HSA-159854Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162587HIV Life Cycle
reactomeR-HSA-162599Late Phase of HIV Life Cycle
reactomeR-HSA-162906HIV Infection
reactomeR-HSA-163841Gamma carboxylation, hypusine formation and arylsulfatase activation
reactomeR-HSA-1643685Disease
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-167060NGF processing
reactomeR-HSA-170834Signaling by TGF-beta Receptor Complex
reactomeR-HSA-171286Synthesis and processing of ENV and VPU
reactomeR-HSA-174824Plasma lipoprotein assembly, remodeling, and clearance
reactomeR-HSA-175474Assembly Of The HIV Virion
reactomeR-HSA-186797Signaling by PDGF
reactomeR-HSA-1912420Pre-NOTCH Processing in Golgi
reactomeR-HSA-1912422Pre-NOTCH Expression and Processing
reactomeR-HSA-2173789TGF-beta receptor signaling activates SMADs
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5210891Uptake and function of anthrax toxins
reactomeR-HSA-5339562Uptake and actions of bacterial toxins
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-6805567Keratinization
reactomeR-HSA-6809371Formation of the cornified envelope
reactomeR-HSA-8963889Assembly of active LPL and LIPC lipase complexes
reactomeR-HSA-8963899Plasma lipoprotein remodeling
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9006936Signaling by TGF-beta family members
reactomeR-HSA-9036866Expression and Processing of Neurotrophins
reactomeR-HSA-977225Amyloid fiber formation
biocartanotchpathwayproteolysis and signaling pathway of notch
kegghsa05164Influenza A - Homo sapiens (human)
pidglypican_3pathwayGlypican 3 network
pidhif1_tfpathwayHIF-1-alpha transcription factor network
pidnotch_pathwayNotch signaling pathway
pidp75ntrpathwayp75(NTR)-mediated signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD123Isoevodiamine3
iGMDRD945ML2141
iGMDRD446LY 21832402
iGMDRD85Ursolic acid4
iGMDRD193Fqi14
iGMDRD61Kinetin riboside1
iGMDRD79Gemcitabine4
iGMDRD126Tipifarnib4
iGMDRD554CHEMBL14341371
iGMDRD151CHM-13
iGMDRD512nutlin 34
iGMDRD1008SR-II-138A5
iGMDRD263AACOCF32
iGMDRD64Parbendazole3
iGMDRD353PD03259012
iGMDRD414MST-3121
iGMDRD871BRD63682
iGMDRD399Selumetinib2
iGMDRD329Merck603
iGMDRD780PP-302
iGMDRD562Navitoclax4
iGMDRD6AM-5803
iGMDRD318PAC-12
iGMDRD481Dactolisib1
iGMDRD77Itraconazole1
iGMDRD137Indisulam2
iGMDRD202Curcumin3
iGMDRD255SB2250022

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FURIN

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