FURIN
Summary: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a role in tumor progression. This gene is located in close proximity to family member proprotein convertase subtilisin/kexin type 6 and upstream of the FES oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| furin, paired basic amino acid cleaving enzyme | MIM:136950 | Ensembl:ENSG00000140564 | HGNC:HGNC:8568 | PA32894 | 15q26.1 |
GO terms in FURIN
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0002020 | protease binding |
| MF | IDA | GO:0004175 | endopeptidase activity |
| MF | TAS | GO:0004175 | endopeptidase activity |
| MF | IDA | GO:0004252 | serine-type endopeptidase activity |
| MF | IMP | GO:0004252 | serine-type endopeptidase activity |
| MF | TAS | GO:0004252 | serine-type endopeptidase activity |
| MF | IDA | GO:0004867 | serine-type endopeptidase inhibitor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008233 | peptidase activity |
| MF | IDA | GO:0042277 | peptide binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IDA | GO:0048406 | nerve growth factor binding |
| BP | IDA | GO:0006465 | signal peptide processing |
| BP | TAS | GO:0006465 | signal peptide processing |
| BP | TAS | GO:0007179 | transforming growth factor beta receptor signaling pathway |
| BP | IMP | GO:0008283 | cell proliferation |
| BP | IEA | GO:0009966 | regulation of signal transduction |
| BP | IEA | GO:0010951 | negative regulation of endopeptidase activity |
| BP | IDA | GO:0016485 | protein processing |
| BP | IMP | GO:0016485 | protein processing |
| BP | IDA | GO:0016486 | peptide hormone processing |
| BP | IEP | GO:0019058 | viral life cycle |
| BP | TAS | GO:0019082 | viral protein processing |
| BP | TAS | GO:0022617 | extracellular matrix disassembly |
| BP | TAS | GO:0030198 | extracellular matrix organization |
| BP | TAS | GO:0030574 | collagen catabolic process |
| BP | IMP | GO:0031638 | zymogen activation |
| BP | IDA | GO:0032804 | negative regulation of low-density lipoprotein particle receptor catabolic process |
| BP | IDA | GO:0032902 | nerve growth factor production |
| BP | IDA | GO:0032904 | negative regulation of nerve growth factor production |
| BP | IMP | GO:0032911 | negative regulation of transforming growth factor beta1 production |
| BP | IDA | GO:0032940 | secretion by cell |
| BP | IMP | GO:0042176 | regulation of protein catabolic process |
| BP | IDA | GO:0043043 | peptide biosynthetic process |
| BP | TAS | GO:0044267 | cellular protein metabolic process |
| BP | IEA | GO:0045714 | regulation of low-density lipoprotein particle receptor biosynthetic process |
| BP | TAS | GO:0051004 | regulation of lipoprotein lipase activity |
| BP | IC | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis |
| BP | IDA | GO:0052548 | regulation of endopeptidase activity |
| BP | TAS | GO:0070268 | cornification |
| BP | IMP | GO:0090472 | dibasic protein processing |
| CC | IMP | GO:0000139 | Golgi membrane |
| CC | TAS | GO:0000139 | Golgi membrane |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IDA | GO:0005615 | extracellular space |
| CC | IGI | GO:0005783 | endoplasmic reticulum |
| CC | TAS | GO:0005796 | Golgi lumen |
| CC | IDA | GO:0005802 | trans-Golgi network |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0009986 | cell surface |
| CC | IEA | GO:0010008 | endosome membrane |
| CC | HDA | GO:0016020 | membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IDA | GO:0030140 | trans-Golgi network transport vesicle |
| CC | IDA | GO:0045121 | membrane raft |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: FURIN
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FURIN
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1181150 | Signaling by NODAL |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1442490 | Collagen degradation |
| reactome | R-HSA-1442490 | Collagen degradation |
| reactome | R-HSA-1474228 | Degradation of the extracellular matrix |
| reactome | R-HSA-1474228 | Degradation of the extracellular matrix |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1566948 | Elastic fibre formation |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-1592389 | Activation of Matrix Metalloproteinases |
| reactome | R-HSA-159782 | Removal of aminoterminal propeptides from gamma-carboxylated proteins |
| reactome | R-HSA-159854 | Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162587 | HIV Life Cycle |
| reactome | R-HSA-162599 | Late Phase of HIV Life Cycle |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-163841 | Gamma carboxylation, hypusine formation and arylsulfatase activation |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-167060 | NGF processing |
| reactome | R-HSA-170834 | Signaling by TGF-beta Receptor Complex |
| reactome | R-HSA-171286 | Synthesis and processing of ENV and VPU |
| reactome | R-HSA-174824 | Plasma lipoprotein assembly, remodeling, and clearance |
| reactome | R-HSA-175474 | Assembly Of The HIV Virion |
| reactome | R-HSA-186797 | Signaling by PDGF |
| reactome | R-HSA-1912420 | Pre-NOTCH Processing in Golgi |
| reactome | R-HSA-1912422 | Pre-NOTCH Expression and Processing |
| reactome | R-HSA-2173789 | TGF-beta receptor signaling activates SMADs |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5210891 | Uptake and function of anthrax toxins |
| reactome | R-HSA-5339562 | Uptake and actions of bacterial toxins |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6805567 | Keratinization |
| reactome | R-HSA-6809371 | Formation of the cornified envelope |
| reactome | R-HSA-8963889 | Assembly of active LPL and LIPC lipase complexes |
| reactome | R-HSA-8963899 | Plasma lipoprotein remodeling |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006936 | Signaling by TGF-beta family members |
| reactome | R-HSA-9036866 | Expression and Processing of Neurotrophins |
| reactome | R-HSA-977225 | Amyloid fiber formation |
| biocarta | notchpathway | proteolysis and signaling pathway of notch |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| pid | glypican_3pathway | Glypican 3 network |
| pid | hif1_tfpathway | HIF-1-alpha transcription factor network |
| pid | notch_pathway | Notch signaling pathway |
| pid | p75ntrpathway | p75(NTR)-mediated signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD945 | ML214 | 1 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD85 | Ursolic acid | 4 |
| iGMDRD193 | Fqi1 | 4 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD79 | Gemcitabine | 4 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD554 | CHEMBL1434137 | 1 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD512 | nutlin 3 | 4 |
| iGMDRD1008 | SR-II-138A | 5 |
| iGMDRD263 | AACOCF3 | 2 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD414 | MST-312 | 1 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD562 | Navitoclax | 4 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD77 | Itraconazole | 1 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD255 | SB225002 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FURIN
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.