THRSP
Summary: The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| thyroid hormone responsive | MIM:601926 | Ensembl:ENSG00000151365 | HGNC:HGNC:11800 | PA36509 | 11q14.1 |
GO terms in THRSP
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IEA | GO:0006629 | lipid metabolic process |
| BP | TAS | GO:0006853 | carnitine shuttle |
| BP | IEA | GO:0010866 | regulation of triglyceride biosynthetic process |
| BP | ISS | GO:0046890 | regulation of lipid biosynthetic process |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | ISS | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IEA | GO:0042803 | protein homodimerization activity |
Gene expression in normal tissue: THRSP
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in THRSP
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-200425 | Import of palmitoyl-CoA into the mitochondrial matrix |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-8978868 | Fatty acid metabolism |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD255 | SB225002 | 3 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD945 | ML214 | 6 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD105 | Triptolide | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in THRSP
CLASSFICATION
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