THRSP

Summary: The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namethyroid hormone responsive
OMIM IDMIM:601926
Ensembl IDEnsembl:ENSG00000151365
HGNC IDHGNC:HGNC:11800
PHARMGKB IDPA36509
Map Location11q14.1

GO terms in THRSP


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IEA GO:0006351 transcription, DNA-templated
BP IEA GO:0006355 regulation of transcription, DNA-templated
BP IEA GO:0006629 lipid metabolic process
BP TAS GO:0006853 carnitine shuttle
BP IEA GO:0010866 regulation of triglyceride biosynthetic process
BP ISS GO:0046890 regulation of lipid biosynthetic process
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Gene expression in normal tissue: THRSP

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 4BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 5LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 3

Gene-drug pathway distribution

undefined3Chromatin histone acetylation1Apoptosis regulation1

Pathways in THRSP


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1430728 Metabolism
reactome R-HSA-200425 Import of palmitoyl-CoA into the mitochondrial matrix
reactome R-HSA-556833 Metabolism of lipids
reactome R-HSA-8978868 Fatty acid metabolism
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD255 SB225002 3
iGMDRD318 PAC-1 1
iGMDRD945 ML214 6
iGMDRD289 Parthenolide 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in THRSP

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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