RARA

Summary: This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameretinoic acid receptor alpha
OMIM IDMIM:180240
Ensembl IDEnsembl:ENSG00000131759
HGNC IDHGNC:HGNC:9864
PHARMGKB IDPA34225
Map Location17q21.2

GO terms in RARA


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IBA GO:0000122 negative regulation of transcription by RNA polymerase II
BP IEA GO:0000122 negative regulation of transcription by RNA polymerase II
BP IEA GO:0001657 ureteric bud development
BP IEA GO:0001843 neural tube closure
BP IBA GO:0001889 liver development
BP IEA GO:0001889 liver development
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Gene expression in normal tissue: RARA

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: ADENOCARCINOMA model num: 20undefinedtissue: undefined cancer: PANCAN model num: 22LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 10BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 5

Gene-drug pathway distribution

undefined5Metabolic pathways1Other, kinases1PI3K/MTOR signaling1Proteasome1Apoptosis regulation1

Pathways in RARA


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Database
Pathway ID
Pathway Des.
biocarta carm1pathway transcription regulation by methyltransferase of carm1
biocarta rarpathway degradation of the rar and rxr by the proteasome
biocarta rarrxrpathway nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-212436 Generic Transcription Pathway
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD280 CYTOCHALASIN B 3
iGMDRD152 179324-69-7 2
iGMDRD366 PI-103 13
iGMDRD562 Navitoclax 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

2undefined1IGF1R1MDM21CXCR21BCL21JAK21PSMB11MTOR1BCL2L2

Gene Structure: PDB

Models in RARA

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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