CDC25A
Summary: CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cell division cycle 25A | MIM:116947 | Ensembl:ENSG00000164045 | HGNC:HGNC:1725 | PA26259 | 3p21.31 |
GO terms in CDC25A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity |
| BP | TAS | GO:0000082 | G1/S transition of mitotic cell cycle |
| BP | IBA | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | TAS | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | TAS | GO:0008283 | cell proliferation |
| BP | IDA | GO:0009314 | response to radiation |
| BP | IBA | GO:0010971 | positive regulation of G2/M transition of mitotic cell cycle |
| BP | TAS | GO:0016579 | protein deubiquitination |
| BP | IDA | GO:0034644 | cellular response to UV |
| BP | IEA | GO:0035335 | peptidyl-tyrosine dephosphorylation |
| BP | IBA | GO:0045931 | positive regulation of mitotic cell cycle |
| BP | IEA | GO:0051301 | cell division |
| BP | TAS | GO:0051726 | regulation of cell cycle |
| BP | IBA | GO:0110032 | positive regulation of G2/MI transition of meiotic cell cycle |
| BP | IEA | GO:1902751 | positive regulation of cell cycle G2/M phase transition |
| CC | IBA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| MF | TAS | GO:0004721 | phosphoprotein phosphatase activity |
| MF | IBA | GO:0004725 | protein tyrosine phosphatase activity |
| MF | IEA | GO:0004725 | protein tyrosine phosphatase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IPI | GO:0051087 | chaperone binding |
Gene expression in normal tissue: CDC25A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDC25A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1530 | miRNA Regulation of DNA Damage Response |
| wikipathways | WP1545 | miRNAs involved in DNA damage response |
| wikipathways | WP179 | Cell Cycle |
| wikipathways | WP1858 | Mitotic G1-G1-S phases |
| wikipathways | WP1859 | Mitotic G2-G2-M phases |
| wikipathways | WP1971 | Integrated Cancer Pathway |
| wikipathways | WP1984 | Integrated Breast Cancer Pathway |
| wikipathways | WP2263 | Androgen Receptor Network in Prostate Cancer |
| wikipathways | WP2446 | Retinoblastoma (RB) in Cancer |
| wikipathways | WP2516 | ATM Signaling Pathway |
| wikipathways | WP2772 | S Phase |
| wikipathways | WP45 | G1 to S cell cycle control |
| wikipathways | WP707 | DNA Damage Response |
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa04914 | Progesterone-mediated oocyte maturation - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| pid | atm_pathway | ATM pathway |
| pid | atr_pathway | ATR signaling pathway |
| pid | e2f_pathway | E2F transcription factor network |
| pid | myc_activpathway | Validated targets of C-MYC transcriptional activation |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| biocarta | cellcyclepathway | cyclins and cell cycle regulation |
| biocarta | g1pathway | cell cycle: g1/s check point |
| reactome | R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex |
| reactome | R-HSA-1538133 | G0 and Early G1 |
| reactome | R-HSA-156711 | Polo-like kinase mediated events |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-176187 | Activation of ATR in response to replication stress |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-5688426 | Deubiquitination |
| reactome | R-HSA-5689880 | Ub-specific processing proteases |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-69202 | Cyclin E associated events during G1/S transition |
| reactome | R-HSA-69206 | G1/S Transition |
| reactome | R-HSA-69242 | S Phase |
| reactome | R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69481 | G2/M Checkpoints |
| reactome | R-HSA-69601 | Ubiquitin Mediated Degradation of Phosphorylated Cdc25A |
| reactome | R-HSA-69610 | p53-Independent DNA Damage Response |
| reactome | R-HSA-69613 | p53-Independent G1/S DNA damage checkpoint |
| reactome | R-HSA-69615 | G1/S DNA Damage Checkpoints |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| reactome | R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry |
| reactome | R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
| reactome | R-HSA-8863678 | Neurodegenerative Diseases |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD255 | SB225002 | 3 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD318 | PAC-1 | 4 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD366 | PI-103 | 2 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD369 | TGX-115 | 2 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD781 | Sirolimus | 4 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD85 | Ursolic acid | 2 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD679 | Bistramide A | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDC25A
CLASSFICATION
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