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RPS6KC1

Summary: Sphingosine kinase catalyzes the formation of sphingosine 1 phosphate, a lipid cellular messenger. The protein encoded by this gene can bind to sphingosine kinase and to phosphatidylinositol 3-phosphate, suggesting a role in sphingosine 1 phophate signaling. The encoded protein can also bind to peroxiredoxin-3 and may help transport it to mitochondria. [provided by RefSeq, Mar 2017].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
ribosomal protein S6 kinase C1	MIM:617517	Ensembl:ENSG00000136643	HGNC:HGNC:10439	PA34854	1q32.3

Gene Categories:

DRUGGABLE GENOME SERINE THREONINE KINASE KINASE

GO terms in RPS6KC1

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IEA	GO:0004674	protein serine/threonine kinase activity
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0005524	ATP binding
MF	IEA	GO:0035091	phosphatidylinositol binding
CC	IDA	GO:0005769	early endosome
CC	IEA	GO:0016020	membrane
BP	IEA	GO:0006468	protein phosphorylation
BP	TAS	GO:0007165	signal transduction

Gene expression in normal tissue: RPS6KC1

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RPS6KC1

Database	Pathway ID	Pathway Des.

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD100	Zebularine	3
iGMDRD871	BRD6368	3
iGMDRD451	Serdemetan	2
iGMDRD60	Quinoclamine	2
iGMDRD255	SB225002	2
iGMDRD202	Curcumin	3
iGMDRD137	Indisulam	2
iGMDRD231	Importazole	2
iGMDRD77	Itraconazole	1
iGMDRD705	Nakiterpiosin	3
iGMDRD193	Fqi1	2
iGMDRD152	179324-69-7	2
iGMDRD446	LY 2183240	5
iGMDRD394	BX-795	3
iGMDRD280	CYTOCHALASIN B	5
iGMDRD123	Isoevodiamine	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RPS6KC1

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DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.