TMEM123
Summary: This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| transmembrane protein 123 | MIM:606356 | Ensembl:ENSG00000152558 | HGNC:HGNC:30138 | PA143485643 | 11q22.2 |
GO terms in TMEM123
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | NAS | GO:0038023 | signaling receptor activity |
| BP | IEA | GO:0007165 | signal transduction |
| BP | IDA | GO:0070267 | oncosis |
| CC | IDA | GO:0009897 | external side of plasma membrane |
| CC | NAS | GO:0016021 | integral component of membrane |
| CC | IBA | GO:0031410 | cytoplasmic vesicle |
Gene expression in normal tissue: TMEM123
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TMEM123
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD366 | PI-103 | 2 |
| iGMDRD314 | Tanespimycin | 3 |
| iGMDRD872 | BRD7137 | 4 |
| iGMDRD871 | BRD6368 | 6 |
| iGMDRD451 | Serdemetan | 1 |
| iGMDRD23 | Gossypol | 4 |
| iGMDRD60 | Quinoclamine | 4 |
| iGMDRD300 | Tozasertib | 4 |
| iGMDRD248 | BRD4354 | 3 |
| iGMDRD255 | SB225002 | 1 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD532 | Olaparib | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TMEM123
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