MERTK
Summary: This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| MER proto-oncogene, tyrosine kinase | MIM:604705 | Ensembl:ENSG00000153208 | HGNC:HGNC:7027 | PA30759 | 2q13 |
GO terms in MERTK
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IBA | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IEA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IBA | GO:0004888 | transmembrane signaling receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0017147 | Wnt-protein binding |
| MF | IBA | GO:0031434 | mitogen-activated protein kinase kinase binding |
| CC | IEA | GO:0001750 | photoreceptor outer segment |
| CC | IDA | GO:0005615 | extracellular space |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | IDA | GO:0016028 | rhabdomere |
| CC | IBA | GO:0043235 | receptor complex |
| BP | IEA | GO:0001779 | natural killer cell differentiation |
| BP | IEA | GO:0001818 | negative regulation of cytokine production |
| BP | TAS | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0006909 | phagocytosis |
| BP | IMP | GO:0006909 | phagocytosis |
| BP | TAS | GO:0007166 | cell surface receptor signaling pathway |
| BP | TAS | GO:0007267 | cell-cell signaling |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | IBA | GO:0009968 | negative regulation of signal transduction |
| BP | IBA | GO:0016055 | Wnt signaling pathway |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IEA | GO:0030168 | platelet activation |
| BP | IEA | GO:0032940 | secretion by cell |
| BP | IBA | GO:0033674 | positive regulation of kinase activity |
| BP | IEA | GO:0034446 | substrate adhesion-dependent cell spreading |
| BP | IBA | GO:0043066 | negative regulation of apoptotic process |
| BP | IEA | GO:0043277 | apoptotic cell clearance |
| BP | IBA | GO:0043410 | positive regulation of MAPK cascade |
| BP | IEA | GO:0043491 | protein kinase B signaling |
| BP | IDA | GO:0050766 | positive regulation of phagocytosis |
| BP | TAS | GO:0050900 | leukocyte migration |
| BP | IEA | GO:0051250 | negative regulation of lymphocyte activation |
| BP | IEA | GO:0060041 | retina development in camera-type eye |
| BP | IEA | GO:0060068 | vagina development |
| BP | IBA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IEA | GO:0097350 | neutrophil clearance |
| BP | IMP | GO:2000107 | negative regulation of leukocyte apoptotic process |
Gene expression in normal tissue: MERTK
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MERTK
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-202733 | Cell surface interactions at the vascular wall |
| wikipathways | WP4180 | Ebola Virus Pathway on Host |
| wikipathways | WP4217 | Ebola Virus Pathway on Host |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD289 | Parthenolide | 4 |
| iGMDRD105 | Triptolide | 6 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD251 | ML162 | 3 |
| iGMDRD121 | GMX1778 | 4 |
| iGMDRD322 | FK 866 | 4 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD886 | Compound 1541A | 5 |
| iGMDRD246 | NPC26 | 7 |
| iGMDRD263 | AACOCF3 | 2 |
| iGMDRD329 | Merck60 | 4 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD882 | CIL41 | 2 |
| iGMDRD701 | NVP-AUY922 | 2 |
| iGMDRD48 | Dexamethasone | 3 |
| iGMDRD486 | Tosedostat | 2 |
| iGMDRD945 | ML214 | 9 |
| iGMDRD883 | CIL55A | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 2 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD341 | Triacsin c | 5 |
| iGMDRD802 | 4-methylfasudil | 1 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD138 | PX 12 | 8 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD64 | Parbendazole | 6 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD188 | Piperlongumine | 6 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD599 | Salermide | 1 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD61 | Kinetin riboside | 4 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD193 | Fqi1 | 6 |
| iGMDRD446 | LY 2183240 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MERTK
CLASSFICATION
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