OXSR1
Summary: The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| oxidative stress responsive 1 | MIM:604046 | Ensembl:ENSG00000172939 | HGNC:HGNC:8508 | PA134973207 | 3p22.2 |
GO terms in OXSR1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006979 | response to oxidative stress |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IDA | GO:0018107 | peptidyl-threonine phosphorylation |
| BP | IBA | GO:0023014 | signal transduction by protein phosphorylation |
| BP | IBA | GO:0032147 | activation of protein kinase activity |
| BP | IDA | GO:0035556 | intracellular signal transduction |
| BP | IEA | GO:0071476 | cellular hypotonic response |
| BP | IEA | GO:1901017 | negative regulation of potassium ion transmembrane transporter activity |
| MF | IDA | GO:0000287 | magnesium ion binding |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | IPI | GO:0042802 | identical protein binding |
Gene expression in normal tissue: OXSR1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in OXSR1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pharmgkb | PA165984799 | Diuretics Pathway, Pharmacodynamics |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD366 | PI-103 | 6 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD506 | Fedratinib | 6 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD286 | Nsc 632839 | 5 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD137 | Indisulam | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in OXSR1
CLASSFICATION
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