MAP2K6


Summary: This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
mitogen-activated protein kinase kinase 6MIM:601254Ensembl:ENSG00000108984HGNC:HGNC:6846PA3059117q24.3

GO terms in MAP2K6


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFIBAGO:0004708MAP kinase kinase activity
MFIDAGO:0004708MAP kinase kinase activity
MFTASGO:0004708MAP kinase kinase activity
MFIEAGO:0004713protein tyrosine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIPIGO:0019901protein kinase binding
BPIEAGO:0000165MAPK cascade
BPIBAGO:0000187activation of MAPK activity
BPIDAGO:0000187activation of MAPK activity
BPTASGO:0000187activation of MAPK activity
BPIEAGO:0002931response to ischemia
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006355regulation of transcription, DNA-templated
BPIEAGO:0006915apoptotic process
BPTASGO:0006975DNA damage induced protein phosphorylation
BPTASGO:0007050cell cycle arrest
BPTASGO:0007165signal transduction
BPIBAGO:0007346regulation of mitotic cell cycle
BPIEAGO:0018108peptidyl-tyrosine phosphorylation
BPIEAGO:0022602ovulation cycle process
BPIBAGO:0023014signal transduction by protein phosphorylation
BPIBAGO:0032147activation of protein kinase activity
BPIEAGO:0032308positive regulation of prostaglandin secretion
BPIEAGO:0042493response to drug
BPIEAGO:0043065positive regulation of apoptotic process
BPIEAGO:0051770positive regulation of nitric-oxide synthase biosynthetic process
BPIEAGO:0060048cardiac muscle contraction
BPTASGO:0070423nucleotide-binding oligomerization domain containing signaling pathway
BPIEAGO:0072709cellular response to sorbitol
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIBAGO:0005737cytoplasm
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIEAGO:0005856cytoskeleton

Gene expression in normal tissue: MAP2K6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAP2K6


DatabasePathway IDPathway Des.
pidanthraxpathwayCellular roles of Anthrax toxin
pidar_tf_pathwayRegulation of Androgen receptor activity
pidcdc42_pathwayCDC42 signaling events
pidcxcr3pathwayCXCR3-mediated signaling events
pidfaspathwayFAS (CD95) signaling pathway
pidil12_2pathwayIL12-mediated signaling events
pidil1pathwayIL1-mediated signaling events
pidil6_7pathwayIL6-mediated signaling events
pidmapktrkpathwayTrk receptor signaling mediated by the MAPK pathway
pidp38_mkk3_6pathwayp38 MAPK signaling pathway
pidp38alphabetapathwayRegulation of p38-alpha and p38-beta
pidp38gammadeltapathwaySignaling mediated by p38-gamma and p38-delta
pidrac1_pathwayRAC1 signaling pathway
pidrhoa_pathwayRhoA signaling pathway
pidvegfr1_2_pathwaySignaling events mediated by VEGFR1 and VEGFR2
pharmgkbPA165985892Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
pharmgkbPA2032VEGF Signaling Pathway
smpdbSMP00320Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
smpdbSMP00321Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
smpdbSMP00358Fc Epsilon Receptor I Signaling in Mast Cells
wikipathwaysWP1449Regulation of toll-like receptor signaling pathway
wikipathwaysWP1544MicroRNAs in cardiomyocyte hypertrophy
wikipathwaysWP185Integrin-mediated Cell Adhesion
wikipathwaysWP195IL-1 signaling pathway
wikipathwaysWP1993Angiogenesis overview
wikipathwaysWP2018RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway
wikipathwaysWP2032Human Thyroid Stimulating Hormone (TSH) signaling pathway
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP23B Cell Receptor Signaling Pathway
wikipathwaysWP231TNF alpha Signaling Pathway
wikipathwaysWP2447Amyotrophic lateral sclerosis (ALS)
wikipathwaysWP2637Structural Pathway of Interleukin 1 (IL-1)
wikipathwaysWP2795Cardiac Hypertrophic Response
wikipathwaysWP3611Photodynamic therapy-induced AP-1 survival signaling.
wikipathwaysWP366TGF-beta Signaling Pathway
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP38794-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP3931ESC Pluripotency Pathways
wikipathwaysWP400p38 MAPK Signaling Pathway
wikipathwaysWP422MAPK Cascade
wikipathwaysWP4239EMT transition in Colorectal Cancer
wikipathwaysWP481Insulin Signaling
wikipathwaysWP585Interferon type I signaling pathways
wikipathwaysWP722Serotonin HTR1 Group and FOS Pathway
wikipathwaysWP75Toll-like Receptor Signaling Pathway
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04620Toll-like receptor signaling pathway - Homo sapiens (human)
kegghsa04664Fc epsilon RI signaling pathway - Homo sapiens (human)
kegghsa04668TNF signaling pathway - Homo sapiens (human)
kegghsa04750Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
kegghsa04912GnRH signaling pathway - Homo sapiens (human)
kegghsa05014Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human)
kegghsa05145Toxoplasmosis - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)
netpathPathway_IL1IL1
netpathPathway_IL6IL6
netpathPathway_TGF_beta_ReceptorTGF_beta_Receptor
netpathPathway_TNFalphaTNFalpha
netpathPathway_TSHTSH
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1643685Disease
reactomeR-HSA-166016Toll Like Receptor 4 (TLR4) Cascade
reactomeR-HSA-166058MyD88:Mal cascade initiated on plasma membrane
reactomeR-HSA-166166MyD88-independent TLR4 cascade
reactomeR-HSA-168138Toll Like Receptor 9 (TLR9) Cascade
reactomeR-HSA-168142Toll Like Receptor 10 (TLR10) Cascade
reactomeR-HSA-168164Toll Like Receptor 3 (TLR3) Cascade
reactomeR-HSA-168176Toll Like Receptor 5 (TLR5) Cascade
reactomeR-HSA-168179Toll Like Receptor TLR1:TLR2 Cascade
reactomeR-HSA-168181Toll Like Receptor 7/8 (TLR7/8) Cascade
reactomeR-HSA-168188Toll Like Receptor TLR6:TLR2 Cascade
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168638NOD1/2 Signaling Pathway
reactomeR-HSA-168643Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
reactomeR-HSA-168898Toll-Like Receptors Cascades
reactomeR-HSA-181438Toll Like Receptor 2 (TLR2) Cascade
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2559580Oxidative Stress Induced Senescence
reactomeR-HSA-2559583Cellular Senescence
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-375170CDO in myogenesis
reactomeR-HSA-446652Interleukin-1 family signaling
reactomeR-HSA-448424Interleukin-17 signaling
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-450294MAP kinase activation
reactomeR-HSA-450302activated TAK1 mediates p38 MAPK activation
reactomeR-HSA-5210891Uptake and function of anthrax toxins
reactomeR-HSA-525793Myogenesis
reactomeR-HSA-5339562Uptake and actions of bacterial toxins
reactomeR-HSA-5633007Regulation of TP53 Activity
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-6804758Regulation of TP53 Activity through Acetylation
reactomeR-HSA-6811555PI5P Regulates TP53 Acetylation
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-9020702Interleukin-1 signaling
reactomeR-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling
reactomeR-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
reactomeR-HSA-975155MyD88 dependent cascade initiated on endosome
reactomeR-HSA-975871MyD88 cascade initiated on plasma membrane
biocarta41bbpathwaythe 41bb-dependent immune response
biocartafmlppathwayfmlp induced chemokine gene expression in hmc-1 cells
biocartagata3pathwaygata3 participate in activating the th2 cytokine genes expression
biocartahcmvpathwayhuman cytomegalovirus and map kinase pathways
biocartail10pathwayil-10 anti-inflammatory signaling pathway
biocartail12pathwayil12 and stat4 dependent signaling pathway in th1 development
biocartail1rpathwaysignal transduction through il1r
biocartakeratinocytepathwaykeratinocyte differentiation
biocartamapkpathwaymapkinase signaling pathway
biocartanthipathwaynfkb activation by nontypeable hemophilus influenzae
biocartap38mapkpathwayp38 mapk signaling pathway
biocartastresspathwaytnf/stress related signaling
biocartatollpathwaytoll-like receptor pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD286Nsc 6328392
iGMDRD255SB2250023
iGMDRD886Compound 1541A2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAP2K6

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