MAP2K6


Summary: This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008].

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GO terms in MAP2K6


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0004674 protein serine/threonine kinase activity
MF TAS GO:0004674 protein serine/threonine kinase activity
MF IBA GO:0004708 MAP kinase kinase activity
MF IDA GO:0004708 MAP kinase kinase activity
MF TAS GO:0004708 MAP kinase kinase activity
MF IEA GO:0004713 protein tyrosine kinase activity
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Gene expression in normal tissue: MAP2K6

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 3OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 2

Gene-drug pathway distribution

Pathways in MAP2K6


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Database
Pathway ID
Pathway Des.
pid anthraxpathway Cellular roles of Anthrax toxin
pid ar_tf_pathway Regulation of Androgen receptor activity
pid cdc42_pathway CDC42 signaling events
pid cxcr3pathway CXCR3-mediated signaling events
pid faspathway FAS (CD95) signaling pathway
pid il12_2pathway IL12-mediated signaling events
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD286 Nsc 632839 2
iGMDRD255 SB225002 3
iGMDRD886 Compound 1541A 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAP2K6

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Level
Reference ID
Tissue
Cancer
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