MAP2K6
Summary: This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:601254 Ensembl IDEnsembl:ENSG00000108984 HGNC IDHGNC:HGNC:6846 PHARMGKB IDPA30591 Map Location17q24.3 |
GO terms in MAP2K6
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
MF | IBA | GO:0004708 | MAP kinase kinase activity |
MF | IDA | GO:0004708 | MAP kinase kinase activity |
MF | TAS | GO:0004708 | MAP kinase kinase activity |
MF | IEA | GO:0004713 | protein tyrosine kinase activity |
Gene expression in normal tissue: MAP2K6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAP2K6
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Database | Pathway ID | Pathway Des. |
---|---|---|
pid | anthraxpathway | Cellular roles of Anthrax toxin |
pid | ar_tf_pathway | Regulation of Androgen receptor activity |
pid | cdc42_pathway | CDC42 signaling events |
pid | cxcr3pathway | CXCR3-mediated signaling events |
pid | faspathway | FAS (CD95) signaling pathway |
pid | il12_2pathway | IL12-mediated signaling events |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in MAP2K6
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |