ORMDL3

Summary:

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameORMDL sphingolipid biosynthesis regulator 3
OMIM IDMIM:610075
Ensembl IDEnsembl:ENSG00000172057
HGNC IDHGNC:HGNC:16038
PHARMGKB IDPA32821
Map Location17q21.1

GO terms in ORMDL3


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IBA GO:0006672 ceramide metabolic process
BP IMP GO:0006672 ceramide metabolic process
BP TAS GO:0043312 neutrophil degranulation
BP IBA GO:0090156 cellular sphingolipid homeostasis
BP IBA GO:1900060 negative regulation of ceramide biosynthetic process
BP IMP GO:1900060 negative regulation of ceramide biosynthetic process
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Gene expression in normal tissue: ORMDL3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined14Longevity regulating pathway1Other, kinases1PI3K/MTOR signaling1Metabolic pathways1

Pathways in ORMDL3


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1430728 Metabolism
reactome R-HSA-1660661 Sphingolipid de novo biosynthesis
reactome R-HSA-168249 Innate Immune System
reactome R-HSA-168256 Immune System
reactome R-HSA-428157 Sphingolipid metabolism
reactome R-HSA-556833 Metabolism of lipids
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD255 SB225002 11
iGMDRD77 Itraconazole 5
iGMDRD68 Paclitaxel 2
iGMDRD434 BMS-536924 5
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ORMDL3

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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