ORMDL3
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ORMDL sphingolipid biosynthesis regulator 3 | MIM:610075 | Ensembl:ENSG00000172057 | HGNC:HGNC:16038 | PA32821 | 17q21.1 |
GO terms in ORMDL3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0006672 | ceramide metabolic process |
| BP | IMP | GO:0006672 | ceramide metabolic process |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IBA | GO:0090156 | cellular sphingolipid homeostasis |
| BP | IBA | GO:1900060 | negative regulation of ceramide biosynthetic process |
| BP | IMP | GO:1900060 | negative regulation of ceramide biosynthetic process |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | TAS | GO:0030667 | secretory granule membrane |
| CC | IBA | GO:0035339 | SPOTS complex |
| CC | IDA | GO:0035339 | SPOTS complex |
| CC | TAS | GO:0035579 | specific granule membrane |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: ORMDL3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ORMDL3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1660661 | Sphingolipid de novo biosynthesis |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-428157 | Sphingolipid metabolism |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD255 | SB225002 | 11 |
| iGMDRD77 | Itraconazole | 5 |
| iGMDRD68 | Paclitaxel | 2 |
| iGMDRD434 | BMS-536924 | 5 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD366 | PI-103 | 9 |
| iGMDRD506 | Fedratinib | 8 |
| iGMDRD286 | Nsc 632839 | 8 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD330 | BRD4132 | 2 |
| iGMDRD781 | Sirolimus | 1 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD154 | NSC23766 | 1 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 2 |
| iGMDRD634 | SCHEMBL2608041 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ORMDL3
CLASSFICATION
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