STARD3
Summary: This gene encodes a member of a subfamily of lipid trafficking proteins that are characterized by a C-terminal steroidogenic acute regulatory domain and an N-terminal metastatic lymph node 64 domain. The encoded protein localizes to the membranes of late endosomes and may be involved in exporting cholesterol. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| StAR related lipid transfer domain containing 3 | MIM:607048 | Ensembl:ENSG00000131748 | HGNC:HGNC:17579 | PA134981867 | 17q12 |
Gene Categories:
TRANSPORTERGO terms in STARD3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0015485 | cholesterol binding |
| MF | IEA | GO:0017127 | cholesterol transporter activity |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| BP | TAS | GO:0006629 | lipid metabolic process |
| BP | TAS | GO:0006700 | C21-steroid hormone biosynthetic process |
| BP | IEA | GO:0006701 | progesterone biosynthetic process |
| BP | TAS | GO:0006839 | mitochondrial transport |
| BP | TAS | GO:0008202 | steroid metabolic process |
| BP | TAS | GO:0008203 | cholesterol metabolic process |
| BP | IDA | GO:0030301 | cholesterol transport |
| BP | IDA | GO:0099044 | vesicle tethering to endoplasmic reticulum |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005739 | mitochondrion |
| CC | HDA | GO:0005765 | lysosomal membrane |
| CC | IDA | GO:0005789 | endoplasmic reticulum membrane |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IDA | GO:0031902 | late endosome membrane |
| CC | IDA | GO:0044232 | organelle membrane contact site |
Gene expression in normal tissue: STARD3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in STARD3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04979 | Cholesterol metabolism - Homo sapiens (human) |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-196071 | Metabolism of steroid hormones |
| reactome | R-HSA-196108 | Pregnenolone biosynthesis |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-8957322 | Metabolism of steroids |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD137 | Indisulam | 1 |
| iGMDRD255 | SB225002 | 5 |
| iGMDRD434 | BMS-536924 | 5 |
| iGMDRD782 | DC-45-A2 | 1 |
| iGMDRD441 | TW 37 | 3 |
| iGMDRD52 | Rotenone | 3 |
| iGMDRD286 | Nsc 632839 | 5 |
| iGMDRD887 | Compound 23 citrate | 4 |
| iGMDRD506 | Fedratinib | 13 |
| iGMDRD780 | PP-30 | 1 |
| iGMDRD366 | PI-103 | 10 |
| iGMDRD23 | Gossypol | 1 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD524 | ISX-9 | 1 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD159 | 3-Chloro-L-alanine | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in STARD3
CLASSFICATION
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