STARD3
Summary: This gene encodes a member of a subfamily of lipid trafficking proteins that are characterized by a C-terminal steroidogenic acute regulatory domain and an N-terminal metastatic lymph node 64 domain. The encoded protein localizes to the membranes of late endosomes and may be involved in exporting cholesterol. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:607048 Ensembl IDEnsembl:ENSG00000131748 HGNC IDHGNC:HGNC:17579 PHARMGKB IDPA134981867 Map Location17q12 | |||||
Gene Categories:
TRANSPORTERGO terms in STARD3
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0015485 | cholesterol binding |
| MF | IEA | GO:0017127 | cholesterol transporter activity |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| BP | TAS | GO:0006629 | lipid metabolic process |
| BP | TAS | GO:0006700 | C21-steroid hormone biosynthetic process |
Gene expression in normal tissue: STARD3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in STARD3
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04979 | Cholesterol metabolism - Homo sapiens (human) |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-196071 | Metabolism of steroid hormones |
| reactome | R-HSA-196108 | Pregnenolone biosynthesis |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-8957322 | Metabolism of steroids |
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Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in STARD3
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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