WBP4
Summary: This gene encodes WW domain-containing binding protein 4. The WW domain represents a small and compact globular structure that interacts with proline-rich ligands. This encoded protein is a general spliceosomal protein that may play a role in cross-intron bridging of U1 and U2 snRNPs in the spliceosomal complex A. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| WW domain binding protein 4 | MIM:604981 | Ensembl:ENSG00000120688 | HGNC:HGNC:12739 | PA37350 | 13q14.11 |
GO terms in WBP4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003676 | nucleic acid binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IPI | GO:0070064 | proline-rich region binding |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0016607 | nuclear speck |
| CC | IDA | GO:0071005 | U2-type precatalytic spliceosome |
| BP | IDA | GO:0000398 | mRNA splicing, via spliceosome |
| BP | TAS | GO:0000398 | mRNA splicing, via spliceosome |
| BP | IDA | GO:0045292 | mRNA cis splicing, via spliceosome |
Gene expression in normal tissue: WBP4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in WBP4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-72163 | mRNA Splicing - Major Pathway |
| reactome | R-HSA-72172 | mRNA Splicing |
| reactome | R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA |
| reactome | R-HSA-8953854 | Metabolism of RNA |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD329 | Merck60 | 2 |
| iGMDRD314 | Tanespimycin | 5 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD511 | CHEMBL399379 | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD434 | BMS-536924 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in WBP4
CLASSFICATION
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