LMNB2
Summary: This gene encodes a B type nuclear lamin. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Mutations in this gene are associated with acquired partial lipodystrophy. [provided by RefSeq, May 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| lamin B2 | MIM:150341 | Ensembl:ENSG00000176619 | HGNC:HGNC:6638 | PA30404 | 19p13.3 |
GO terms in LMNB2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ND | GO:0003674 | molecular_function |
| MF | IEA | GO:0005198 | structural molecule activity |
| MF | IPI | GO:0005515 | protein binding |
| CC | IEA | GO:0005637 | nuclear inner membrane |
| CC | IEA | GO:0005638 | lamin filament |
| CC | IDA | GO:0031965 | nuclear membrane |
| BP | ND | GO:0008150 | biological_process |
Gene expression in normal tissue: LMNB2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LMNB2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | caspasepathway | caspase cascade in apoptosis |
| biocarta | hivnefpathway | hiv-1 nef: negative effector of fas and tnf |
| biocarta | tnfr1pathway | tnfr1 signaling pathway |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2003 | miR-targeted genes in leukocytes - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2363 | Gastric Cancer Network 2 |
| wikipathways | WP314 | Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| pid | caspase_pathway | Caspase Cascade in Apoptosis |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD85 | Ursolic acid | 6 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD219 | Bax channel blocker | 3 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD781 | Sirolimus | 4 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD562 | Navitoclax | 9 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD506 | Fedratinib | 6 |
| iGMDRD246 | NPC26 | 1 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD226 | ML006 | 3 |
| iGMDRD318 | PAC-1 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LMNB2
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