LMNB2


Summary: This gene encodes a B type nuclear lamin. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Mutations in this gene are associated with acquired partial lipodystrophy. [provided by RefSeq, May 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
lamin B2MIM:150341Ensembl:ENSG00000176619HGNC:HGNC:6638PA3040419p13.3

GO terms in LMNB2


Term TypeEvidence TypeGO Term IDGO Des.
MFNDGO:0003674molecular_function
MFIEAGO:0005198structural molecule activity
MFIPIGO:0005515protein binding
CCIEAGO:0005637nuclear inner membrane
CCIEAGO:0005638lamin filament
CCIDAGO:0031965nuclear membrane
BPNDGO:0008150biological_process

Gene expression in normal tissue: LMNB2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LMNB2


DatabasePathway IDPathway Des.
biocartacaspasepathwaycaspase cascade in apoptosis
biocartahivnefpathwayhiv-1 nef: negative effector of fas and tnf
biocartatnfr1pathwaytnfr1 signaling pathway
wikipathwaysWP2002miR-targeted genes in epithelium - TarBase
wikipathwaysWP2003miR-targeted genes in leukocytes - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP2363Gastric Cancer Network 2
wikipathwaysWP314Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation
kegghsa04210Apoptosis - Homo sapiens (human)
pidcaspase_pathwayCaspase Cascade in Apoptosis

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD85Ursolic acid6
iGMDRD61Kinetin riboside3
iGMDRD219Bax channel blocker3
iGMDRD679Bistramide A2
iGMDRD126Tipifarnib3
iGMDRD599Salermide3
iGMDRD424Tamatinib3
iGMDRD781Sirolimus4
iGMDRD872BRD71373
iGMDRD871BRD63683
iGMDRD562Navitoclax9
iGMDRD329Merck603
iGMDRD506Fedratinib6
iGMDRD246NPC261
iGMDRD886Compound 1541A3
iGMDRD300Tozasertib3
iGMDRD5Tyrphostin AG 14783
iGMDRD255SB2250023
iGMDRD782DC-45-A23
iGMDRD267Oligomycin A3
iGMDRD77Itraconazole3
iGMDRD226ML0063
iGMDRD318PAC-13

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LMNB2

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