LMNB2
Summary: This gene encodes a B type nuclear lamin. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Mutations in this gene are associated with acquired partial lipodystrophy. [provided by RefSeq, May 2012].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Namelamin B2 OMIM IDMIM:150341 Ensembl IDEnsembl:ENSG00000176619 HGNC IDHGNC:HGNC:6638 PHARMGKB IDPA30404 Map Location19p13.3 | |||||
GO terms in LMNB2
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ND | GO:0003674 | molecular_function |
| MF | IEA | GO:0005198 | structural molecule activity |
| MF | IPI | GO:0005515 | protein binding |
| CC | IEA | GO:0005637 | nuclear inner membrane |
| CC | IEA | GO:0005638 | lamin filament |
| CC | IDA | GO:0031965 | nuclear membrane |
Gene expression in normal tissue: LMNB2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LMNB2
Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | caspasepathway | caspase cascade in apoptosis |
| biocarta | hivnefpathway | hiv-1 nef: negative effector of fas and tnf |
| biocarta | tnfr1pathway | tnfr1 signaling pathway |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2003 | miR-targeted genes in leukocytes - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LMNB2
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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