PEMT
Summary: Phosphatidylcholine (PC) is the most abundant mammalian phospholipid. This gene encodes an enzyme which converts phosphatidylethanolamine to phosphatidylcholine by sequential methylation in the liver. Another distinct synthetic pathway in nucleated cells converts intracellular choline to phosphatidylcholine by a three-step process. The protein isoforms encoded by this gene localize to the endoplasmic reticulum and mitochondria-associated membranes. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| phosphatidylethanolamine N-methyltransferase | MIM:602391 | Ensembl:ENSG00000133027 | HGNC:HGNC:8830 | PA33175 | 17p11.2 |
Gene Categories:
DRUG RESISTANCEGO terms in PEMT
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0006629 | lipid metabolic process |
| BP | IBA | GO:0006656 | phosphatidylcholine biosynthetic process |
| BP | IEA | GO:0006656 | phosphatidylcholine biosynthetic process |
| BP | TAS | GO:0006656 | phosphatidylcholine biosynthetic process |
| BP | IEA | GO:0006686 | sphingomyelin biosynthetic process |
| BP | TAS | GO:0008283 | cell proliferation |
| BP | IEA | GO:0008285 | negative regulation of cell proliferation |
| BP | IEA | GO:0032259 | methylation |
| BP | IEA | GO:0033273 | response to vitamin |
| BP | IEA | GO:0043200 | response to amino acid |
| BP | IEA | GO:0045471 | response to ethanol |
| BP | IEA | GO:0046498 | S-adenosylhomocysteine metabolic process |
| BP | IEA | GO:0046500 | S-adenosylmethionine metabolic process |
| BP | IEA | GO:0050747 | positive regulation of lipoprotein metabolic process |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0031526 | brush border membrane |
| CC | IEA | GO:0031966 | mitochondrial membrane |
| CC | IEA | GO:0042383 | sarcolemma |
| MF | IEA | GO:0000773 | phosphatidyl-N-methylethanolamine N-methyltransferase activity |
| MF | IBA | GO:0004608 | phosphatidylethanolamine N-methyltransferase activity |
| MF | TAS | GO:0004608 | phosphatidylethanolamine N-methyltransferase activity |
| MF | IEA | GO:0008429 | phosphatidylethanolamine binding |
| MF | IEA | GO:0080101 | phosphatidyl-N-dimethylethanolamine N-methyltransferase activity |
Gene expression in normal tissue: PEMT
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PEMT
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00564 | Glycerophospholipid metabolism - Homo sapiens (human) |
| smpdb | SMP00025 | Phospholipid Biosynthesis |
| smpdb | SMP00123 | Betaine Metabolism |
| wikipathways | WP3933 | Kennedy pathway from Sphingolipids |
| wikipathways | WP3940 | One carbon metabolism and related pathways |
| wikipathways | WP528 | Acetylcholine Synthesis |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1483191 | Synthesis of PC |
| reactome | R-HSA-1483206 | Glycerophospholipid biosynthesis |
| reactome | R-HSA-1483257 | Phospholipid metabolism |
| reactome | R-HSA-556833 | Metabolism of lipids |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD366 | PI-103 | 7 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD188 | Piperlongumine | 5 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PEMT
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