PEMT
Summary: Phosphatidylcholine (PC) is the most abundant mammalian phospholipid. This gene encodes an enzyme which converts phosphatidylethanolamine to phosphatidylcholine by sequential methylation in the liver. Another distinct synthetic pathway in nucleated cells converts intracellular choline to phosphatidylcholine by a three-step process. The protein isoforms encoded by this gene localize to the endoplasmic reticulum and mitochondria-associated membranes. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2012].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:602391 Ensembl IDEnsembl:ENSG00000133027 HGNC IDHGNC:HGNC:8830 PHARMGKB IDPA33175 Map Location17p11.2 | |||||
Gene Categories:
DRUG RESISTANCEGO terms in PEMT
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0006629 | lipid metabolic process |
| BP | IBA | GO:0006656 | phosphatidylcholine biosynthetic process |
| BP | IEA | GO:0006656 | phosphatidylcholine biosynthetic process |
| BP | TAS | GO:0006656 | phosphatidylcholine biosynthetic process |
| BP | IEA | GO:0006686 | sphingomyelin biosynthetic process |
| BP | TAS | GO:0008283 | cell proliferation |
Gene expression in normal tissue: PEMT
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PEMT
Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00564 | Glycerophospholipid metabolism - Homo sapiens (human) |
| smpdb | SMP00025 | Phospholipid Biosynthesis |
| smpdb | SMP00123 | Betaine Metabolism |
| wikipathways | WP3933 | Kennedy pathway from Sphingolipids |
| wikipathways | WP3940 | One carbon metabolism and related pathways |
| wikipathways | WP528 | Acetylcholine Synthesis |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PEMT
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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