ETV1
Summary: This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ETS variant 1 | MIM:600541 | Ensembl:ENSG00000006468 | HGNC:HGNC:3490 | PA27904 | 7p21.2 |
Gene Categories:
CLINICALLY ACTIONABLEGO terms in ETV1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IBA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
| BP | IBA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | IEA | GO:0007411 | axon guidance |
| BP | IEA | GO:0007517 | muscle organ development |
| BP | IEA | GO:0007638 | mechanosensory behavior |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0048935 | peripheral nervous system neuron development |
| CC | IBA | GO:0005634 | nucleus |
Gene expression in normal tissue: ETV1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ETV1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | p38_mk2pathway | p38 signaling mediated by MAPKAP kinases |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD583 | LDN 193189 | 1 |
| iGMDRD781 | Sirolimus | 4 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD546 | BMS-754807 | 1 |
| iGMDRD219 | Bax channel blocker | 1 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD314 | Tanespimycin | 2 |
| iGMDRD639 | YK 4-279 | 2 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD297 | Austocystin D | 4 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD255 | SB225002 | 1 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD247 | Blebbistatin | 3 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD105 | Triptolide | 1 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD286 | Nsc 632839 | 1 |
| iGMDRD60 | Quinoclamine | 4 |
| iGMDRD505 | Pevonedistat | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ETV1
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