ETV1

Summary: This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2016].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameETS variant 1
OMIM IDMIM:600541
Ensembl IDEnsembl:ENSG00000006468
HGNC IDHGNC:HGNC:3490
PHARMGKB IDPA27904
Map Location7p21.2

Gene Categories:

CLINICALLY ACTIONABLE

GO terms in ETV1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding
MF IBA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF ISA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF ISM GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF NAS GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF IDA GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
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Gene expression in normal tissue: ETV1

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 41BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 12LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 3BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 2

Gene-drug pathway distribution

undefined20Apoptosis regulation2One carbon pool by folate1Ferroptosis1Protein stability and degradation1Longevity regulating pathway1IGFR signaling1

Pathways in ETV1


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Database
Pathway ID
Pathway Des.
pid p38_mk2pathway p38 signaling mediated by MAPKAP kinases
kegg hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD512 nutlin 3 3
iGMDRD583 LDN 193189 1
iGMDRD781 Sirolimus 4
iGMDRD424 Tamatinib 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ETV1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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