ETV1


Summary: This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ETS variant 1MIM:600541Ensembl:ENSG00000006468HGNC:HGNC:3490PA279047p21.2

Gene Categories:

CLINICALLY ACTIONABLE

GO terms in ETV1


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFIBAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIDAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFTASGO:0003700DNA-binding transcription factor activity
MFIPIGO:0005515protein binding
BPIBAGO:0006357regulation of transcription by RNA polymerase II
BPIEAGO:0006366transcription by RNA polymerase II
BPIEAGO:0007411axon guidance
BPIEAGO:0007517muscle organ development
BPIEAGO:0007638mechanosensory behavior
BPIBAGO:0030154cell differentiation
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPTASGO:0048935peripheral nervous system neuron development
CCIBAGO:0005634nucleus

Gene expression in normal tissue: ETV1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ETV1


DatabasePathway IDPathway Des.
pidp38_mk2pathwayp38 signaling mediated by MAPKAP kinases
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD512nutlin 33
iGMDRD583LDN 1931891
iGMDRD781Sirolimus4
iGMDRD424Tamatinib3
iGMDRD546BMS-7548071
iGMDRD219Bax channel blocker1
iGMDRD61Kinetin riboside2
iGMDRD193Fqi12
iGMDRD314Tanespimycin2
iGMDRD639YK 4-2792
iGMDRD154NSC237663
iGMDRD280CYTOCHALASIN B2
iGMDRD466Chaetocin3
iGMDRD297Austocystin D4
iGMDRD211(1S,3R)-RSL32
iGMDRD255SB2250021
iGMDRD260FQI-21
iGMDRD247Blebbistatin3
iGMDRD318PAC-12
iGMDRD434BMS-5369243
iGMDRD171Pemetrexed2
iGMDRD105Triptolide1
iGMDRD562Navitoclax2
iGMDRD872BRD71372
iGMDRD286Nsc 6328391
iGMDRD60Quinoclamine4
iGMDRD505Pevonedistat1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ETV1

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