FUS
Summary: This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| FUS RNA binding protein | MIM:137070 | Ensembl:ENSG00000089280 | HGNC:HGNC:4010 | PA28425 | 16p11.2 |
GO terms in FUS
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003677 | DNA binding |
| MF | IBA | GO:0003712 | transcription coregulator activity |
| MF | IDA | GO:0003713 | transcription coactivator activity |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0030331 | estrogen receptor binding |
| MF | IEA | GO:0031489 | myosin V binding |
| MF | IEA | GO:0035255 | ionotropic glutamate receptor binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IEA | GO:0046965 | retinoid X receptor binding |
| MF | IEA | GO:0046966 | thyroid hormone receptor binding |
| BP | TAS | GO:0000398 | mRNA splicing, via spliceosome |
| BP | IEA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IEA | GO:0071277 | cellular response to calcium ion |
| BP | IEA | GO:1903508 | positive regulation of nucleic acid-templated transcription |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005844 | polysome |
| CC | IEA | GO:0043204 | perikaryon |
| CC | IEA | GO:0044327 | dendritic spine head |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
Gene expression in normal tissue: FUS
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FUS
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-72163 | mRNA Splicing - Major Pathway |
| reactome | R-HSA-72172 | mRNA Splicing |
| reactome | R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| wikipathways | WP411 | mRNA Processing |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD231 | Importazole | 3 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD229 | B02 | 3 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD71 | Sparfosic acid | 3 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD61 | Kinetin riboside | 5 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FUS
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