IRF4


Summary: The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
interferon regulatory factor 4MIM:601900Ensembl:ENSG00000137265HGNC:HGNC:6119PA299186p25.3

GO terms in IRF4


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIDAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFISSGO:0003700DNA-binding transcription factor activity
MFNASGO:0003700DNA-binding transcription factor activity
MFIPIGO:0005515protein binding
MFNASGO:0008134transcription factor binding
MFIEAGO:0016279protein-lysine N-methyltransferase activity
MFISSGO:0043565sequence-specific DNA binding
BPIEAGO:0006366transcription by RNA polymerase II
BPIEAGO:0018022peptidyl-lysine methylation
BPTASGO:0019221cytokine-mediated signaling pathway
BPIEAGO:0034122negative regulation of toll-like receptor signaling pathway
BPNASGO:0042110T cell activation
BPISSGO:0042832defense response to protozoan
BPIEAGO:0043011myeloid dendritic cell differentiation
BPIEAGO:0043388positive regulation of DNA binding
BPIEAGO:0043966histone H3 acetylation
BPIEAGO:0043967histone H4 acetylation
BPIDAGO:0045082positive regulation of interleukin-10 biosynthetic process
BPIDAGO:0045086positive regulation of interleukin-2 biosynthetic process
BPIDAGO:0045368positive regulation of interleukin-13 biosynthetic process
BPIDAGO:0045404positive regulation of interleukin-4 biosynthetic process
BPNASGO:0045622regulation of T-helper cell differentiation
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPTASGO:0060333interferon-gamma-mediated signaling pathway
BPTASGO:0060337type I interferon signaling pathway
BPISSGO:0072540T-helper 17 cell lineage commitment
CCIEAGO:0000788nuclear nucleosome
CCICGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005829cytosol
CCHDAGO:0016020membrane

Gene expression in normal tissue: IRF4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IRF4


DatabasePathway IDPathway Des.
wikipathwaysWP23B Cell Receptor Signaling Pathway
wikipathwaysWP254Apoptosis
wikipathwaysWP2877Vitamin D Receptor Pathway
wikipathwaysWP3527Preimplantation Embryo
wikipathwaysWP3639Apoptotic Signaling Pathway
wikipathwaysWP3892Development of pulmonary dendritic cells and macrophage subsets
wikipathwaysWP3946White fat cell differentiation
wikipathwaysWP3995Prion disease pathway
wikipathwaysWP4066Interleukin-4 and 13 signaling
wikipathwaysWP4149White fat cell differentiation
wikipathwaysWP619Type II interferon signaling (IFNG)
wikipathwaysWP69T-Cell antigen Receptor (TCR) Signaling Pathway
kegghsa04659Th17 cell differentiation - Homo sapiens (human)
pidil4_2pathwayIL4-mediated signaling events
pidnfat_tfpathwayCalcineurin-regulated NFAT-dependent transcription in lymphocytes
biocartapcafpathwaythe information processing pathway at the ifn beta enhancer
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-168256Immune System
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-6785807Interleukin-4 and Interleukin-13 signaling
reactomeR-HSA-877300Interferon gamma signaling
reactomeR-HSA-909733Interferon alpha/beta signaling
reactomeR-HSA-913531Interferon Signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD781Sirolimus2
iGMDRD945ML2143
iGMDRD61Kinetin riboside4
iGMDRD318PAC-12
iGMDRD187BRD98761
iGMDRD77Itraconazole2
iGMDRD105Triptolide2
iGMDRD434BMS-5369243
iGMDRD255SB2250022
iGMDRD513BML-2591
iGMDRD451Serdemetan2
iGMDRD886Compound 1541A2
iGMDRD300Tozasertib2
iGMDRD60Quinoclamine2
iGMDRD329Merck602
iGMDRD577BIX012942
iGMDRD562Navitoclax6
iGMDRD100Zebularine3
iGMDRD188Piperlongumine2
iGMDRD871BRD63682
iGMDRD872BRD71372

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IRF4

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