IRF4
Summary: The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| interferon regulatory factor 4 | MIM:601900 | Ensembl:ENSG00000137265 | HGNC:HGNC:6119 | PA29918 | 6p25.3 |
GO terms in IRF4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISS | GO:0003700 | DNA-binding transcription factor activity |
| MF | NAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | NAS | GO:0008134 | transcription factor binding |
| MF | IEA | GO:0016279 | protein-lysine N-methyltransferase activity |
| MF | ISS | GO:0043565 | sequence-specific DNA binding |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | IEA | GO:0018022 | peptidyl-lysine methylation |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IEA | GO:0034122 | negative regulation of toll-like receptor signaling pathway |
| BP | NAS | GO:0042110 | T cell activation |
| BP | ISS | GO:0042832 | defense response to protozoan |
| BP | IEA | GO:0043011 | myeloid dendritic cell differentiation |
| BP | IEA | GO:0043388 | positive regulation of DNA binding |
| BP | IEA | GO:0043966 | histone H3 acetylation |
| BP | IEA | GO:0043967 | histone H4 acetylation |
| BP | IDA | GO:0045082 | positive regulation of interleukin-10 biosynthetic process |
| BP | IDA | GO:0045086 | positive regulation of interleukin-2 biosynthetic process |
| BP | IDA | GO:0045368 | positive regulation of interleukin-13 biosynthetic process |
| BP | IDA | GO:0045404 | positive regulation of interleukin-4 biosynthetic process |
| BP | NAS | GO:0045622 | regulation of T-helper cell differentiation |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0060333 | interferon-gamma-mediated signaling pathway |
| BP | TAS | GO:0060337 | type I interferon signaling pathway |
| BP | ISS | GO:0072540 | T-helper 17 cell lineage commitment |
| CC | IEA | GO:0000788 | nuclear nucleosome |
| CC | IC | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | HDA | GO:0016020 | membrane |
Gene expression in normal tissue: IRF4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IRF4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| wikipathways | WP3527 | Preimplantation Embryo |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| wikipathways | WP3892 | Development of pulmonary dendritic cells and macrophage subsets |
| wikipathways | WP3946 | White fat cell differentiation |
| wikipathways | WP3995 | Prion disease pathway |
| wikipathways | WP4066 | Interleukin-4 and 13 signaling |
| wikipathways | WP4149 | White fat cell differentiation |
| wikipathways | WP619 | Type II interferon signaling (IFNG) |
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| kegg | hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| pid | il4_2pathway | IL4-mediated signaling events |
| pid | nfat_tfpathway | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| biocarta | pcafpathway | the information processing pathway at the ifn beta enhancer |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
| reactome | R-HSA-877300 | Interferon gamma signaling |
| reactome | R-HSA-909733 | Interferon alpha/beta signaling |
| reactome | R-HSA-913531 | Interferon Signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD61 | Kinetin riboside | 4 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD513 | BML-259 | 1 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD872 | BRD7137 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IRF4
CLASSFICATION
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