MYO3A
Summary: The protein encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. The protein encoded by this gene plays an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss. Expression of this gene is highly restricted, with the strongest expression in retina and cochlea. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| myosin IIIA | MIM:606808 | Ensembl:ENSG00000095777 | HGNC:HGNC:7601 | PA31405 | 10p12.1 |
GO terms in MYO3A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000146 | microfilament motor activity |
| MF | IMP | GO:0000146 | microfilament motor activity |
| MF | IEA | GO:0003779 | actin binding |
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | IEA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005516 | calmodulin binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0030898 | actin-dependent ATPase activity |
| MF | IDA | GO:0043531 | ADP binding |
| MF | IDA | GO:0060002 | plus-end directed microfilament motor activity |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0016459 | myosin complex |
| CC | IDA | GO:0030175 | filopodium |
| CC | IDA | GO:0031941 | filamentous actin |
| CC | ISS | GO:0032426 | stereocilium tip |
| CC | IDA | GO:0032433 | filopodium tip |
| BP | IEA | GO:0007601 | visual perception |
| BP | IMP | GO:0007605 | sensory perception of sound |
| BP | ISS | GO:0007605 | sensory perception of sound |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IEA | GO:0050896 | response to stimulus |
| BP | ISS | GO:0090103 | cochlea morphogenesis |
Gene expression in normal tissue: MYO3A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MYO3A
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD147 | Prima-1 | 3 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD662 | JQ-1 | 2 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD415 | LE-135 | 3 |
| iGMDRD77 | Itraconazole | 6 |
| iGMDRD267 | Oligomycin A | 2 |
| iGMDRD213 | SMR000068650 | 1 |
| iGMDRD251 | ML162 | 2 |
| iGMDRD158 | NSC141540 | 4 |
| iGMDRD202 | Curcumin | 6 |
| iGMDRD177 | Teniposide | 2 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD85 | Ursolic acid | 2 |
| iGMDRD499 | PDMP | 2 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD48 | Dexamethasone | 1 |
| iGMDRD607 | Ubistatin B | 1 |
| iGMDRD248 | BRD4354 | 2 |
| iGMDRD690 | PRIMA-1MET | 4 |
| iGMDRD369 | TGX-115 | 1 |
| iGMDRD60 | Quinoclamine | 5 |
| iGMDRD268 | Cerulenin | 3 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD524 | ISX-9 | 2 |
| iGMDRD444 | Tivantinib | 1 |
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD730 | Kahalalide F | 1 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD577 | BIX01294 | 1 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD885 | Compound 110 | 5 |
| iGMDRD270 | Ciclosporin | 1 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD297 | Austocystin D | 4 |
| iGMDRD394 | BX-795 | 5 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD634 | SCHEMBL2608041 | 1 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD126 | Tipifarnib | 5 |
| iGMDRD76 | Simvastatin | 1 |
| iGMDRD554 | CHEMBL1434137 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MYO3A
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.