MYO3A

Summary: The protein encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. The protein encoded by this gene plays an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss. Expression of this gene is highly restricted, with the strongest expression in retina and cochlea. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namemyosin IIIA
OMIM IDMIM:606808
Ensembl IDEnsembl:ENSG00000095777
HGNC IDHGNC:HGNC:7601
PHARMGKB IDPA31405
Map Location10p12.1

GO terms in MYO3A


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0000146 microfilament motor activity
MF IMP GO:0000146 microfilament motor activity
MF IEA GO:0003779 actin binding
MF IDA GO:0004672 protein kinase activity
MF IEA GO:0004674 protein serine/threonine kinase activity
MF IPI GO:0005515 protein binding
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Gene expression in normal tissue: MYO3A

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 53undefinedtissue: undefined cancer: SMALL_CELL_CARCINOMA model num: 3BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 24LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 19BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 1UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 8OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 6

Gene-drug pathway distribution

undefined34Other, kinases1Apoptosis regulation1Th17 cell differentiation1Terpenoid backbone biosynthesis1IGFR signaling1ERK MAPK signaling1Biosynthesis of secondary metabolites1DNA replication1Chromatin other1

Pathways in MYO3A


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Database
Pathway ID
Pathway Des.
No matching records found

Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD147 Prima-1 3
iGMDRD82 Quiflapon 2
iGMDRD662 JQ-1 2
iGMDRD434 BMS-536924 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MYO3A

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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