MYO3A Summary: The protein encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. The protein encoded by this gene plays an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss. Expression of this gene is highly restricted, with the strongest expression in retina and cochlea. [provided by RefSeq, Jul 2008].
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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
GO terms in MYO3A
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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0000146 microfilament motor activity MF IMP GO:0000146 microfilament motor activity MF IEA GO:0003779 actin binding MF IDA GO:0004672 protein kinase activity MF IEA GO:0004674 protein serine/threonine kinase activity MF IPI GO:0005515 protein binding
Gene expression in normal tissue: MYO3A
Select Project:
Transcriptome or Gene expression: PRJEB2445
Transcriptome or Gene expression: PRJEB4337
Transcriptome or Gene expression: PRJNA270632
Transcriptome or Gene expression: PRJNA280600
16 tissues mixture adipose adrenal brain breast colon heart kidney liver lung lymph node ovary prostate skeletal muscle testes thyroid white blood cells Export visualization to SVG
Gene-model tissue-cancer distribution: Bubble Plot undefine tissue: undefine
cancer: undefined
model num: 0 undefined tissue: undefined
cancer: PANCAN
model num: 53 undefined tissue: undefined
cancer: SMALL_CELL_CARCINOMA
model num: 3 BLOO tissue: BLOO
cancer: BLOOD
model num: 0 BLOOD tissue: BLOOD
cancer: undefined
model num: 24 LUN tissue: LUN
cancer: LUNG
model num: 0 LUNG tissue: LUNG
cancer: undefined
model num: 19 BOWE tissue: BOWE
cancer: BOWEL
model num: 0 BOWEL tissue: BOWEL
cancer: undefined
model num: 1 UTERU tissue: UTERU
cancer: UTERUS
model num: 0 UTERUS tissue: UTERUS
cancer: Endometrial Carcinoma (UCEC)
model num: 8 OVAR tissue: OVAR
cancer: OVARY
model num: 0 OVARY tissue: OVARY
cancer: undefined
model num: 6
Export visualization to SVG Gene-drug pathway distribution undefined 34 Other, kinases 1 Apoptosis regulation 1 Th17 cell differentiation 1 Terpenoid backbone biosynthesis 1 IGFR signaling 1 ERK MAPK signaling 1 Biosynthesis of secondary metabolites 1 DNA replication 1 Chromatin other 1
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Pathways in MYO3A
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Database
Pathway ID
Pathway Des.
No matching records found
Gene-Drug: Aster Plot
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Gene in drug-gene network: Network Plot CREBBP CREBBP PRKCB PRKCB KAT6B KAT6B MYCL MYCL MINK1 MINK1 FHIT FHIT ZFP69B ZFP69B MSH3 MSH3 BRAF BRAF CBL CBL PIK3CG PIK3CG PRKAA2 PRKAA2 ZFYVE9 ZFYVE9 SLC45A2 SLC45A2 PTPRU PTPRU DHFR DHFR Prima-1 Prima-1 XIAP XIAP DRD2 DRD2 BIRC2 BIRC2 OSR1 OSR1 AMER1 AMER1 EGFR EGFR MFSD2A MFSD2A RET RET LOC654780 LOC654780 FAM118A FAM118A ACKR3 ACKR3 KDM6A KDM6A Quiflapon Quiflapon NKX2-1 NKX2-1 ADGRB3 ADGRB3 TENM1 TENM1 NFKBIA NFKBIA NLRP3 NLRP3 PRAG1 PRAG1 EML4 EML4 UNC79 UNC79 MAPK10 MAPK10 JQ-1 JQ-1 ERC1 ERC1 KRAS KRAS CHRNA5 CHRNA5 URB2 URB2 FLI1 FLI1 GUCY1A2 GUCY1A2 IKZF3 IKZF3 SYK SYK WRN WRN TEK TEK BRCA1 BRCA1 BRCA2 BRCA2 TBCK TBCK DNAH8 DNAH8 LRRK2 LRRK2 PTEN PTEN MYLK3 MYLK3 PRPF4B PRPF4B HECW1 HECW1 GRB7 GRB7 BMS-536924 BMS-536924 PIK3CA PIK3CA LE-135 LE-135 PHKG2 PHKG2 TSHR TSHR ADAM18 ADAM18 COL4A3BP COL4A3BP TBX18 TBX18 RPS6KL1 RPS6KL1 STK39 STK39 MCM4 MCM4 THRAP3 THRAP3 MARK1 MARK1 MAP4K4 MAP4K4 MAP3K1 MAP3K1 NCOA3 NCOA3 MYC MYC LRP1B LRP1B PRDM16 PRDM16 PRKD1 PRKD1 EHBP1 EHBP1 TSSK3 TSSK3 Itraconazole Itraconazole ADAMTS20 ADAMTS20 C1D C1D FES FES HNF1B HNF1B PCDH15 PCDH15 CDK4 CDK4 LHFPL6 LHFPL6 TBK1 TBK1 Oligomycin A Oligomycin A SOX11 SOX11 ADK ADK SIK2 SIK2 POU2AF1 POU2AF1 CDKN2A CDKN2A CHD9 CHD9 CYP1A2 CYP1A2 TFR2 TFR2 CDKN2B CDKN2B SMR000068650 SMR000068650 FGFR1OP FGFR1OP SERPINA12 SERPINA12 PLAT PLAT YAP1 YAP1 STK11 STK11 KDR KDR PSKH2 PSKH2 GMPS GMPS MAP4K2 MAP4K2 ITK ITK HOXD13 HOXD13 CDK17 CDK17 GRIK1 GRIK1 RB1 RB1 TGFB1 TGFB1 ZNF331 ZNF331 MYH11 MYH11 ML162 ML162 DLC1 DLC1 SOX2 SOX2 UNC13C UNC13C ERBB4 ERBB4 TMEM74 TMEM74 JARID2 JARID2 GSK3A GSK3A CLTC CLTC FGFR4 FGFR4 RAD50 RAD50 PPARGC1A PPARGC1A NSC141540 NSC141540 WNK1 WNK1 CNTRL CNTRL CUBN CUBN IL1R1 IL1R1 PRKCG PRKCG EIF3A EIF3A Curcumin Curcumin CEBPA CEBPA Teniposide Teniposide SERPINA2 SERPINA2 HDAC2 HDAC2 ADGRG4 ADGRG4 AKT1 AKT1 CHN1 CHN1 MERTK MERTK MAPK7 MAPK7 CSNK1G2 CSNK1G2 TMPRSS2 TMPRSS2 CNTN6 CNTN6 ML214 ML214 ALK ALK ARHGEF12 ARHGEF12 MGA MGA ALDH7A1 ALDH7A1 LMNB2 LMNB2 SGK1 SGK1 TAF1 TAF1 LRP6 LRP6 Ursolic acid Ursolic acid CTSS CTSS TTK TTK DVL1P1 DVL1P1 BRDT BRDT NCAM1 NCAM1 ALPK3 ALPK3 TP63 TP63 COL18A1 COL18A1 PIK3C2G PIK3C2G PDMP PDMP CHUK CHUK ADAM22 ADAM22 EP300 EP300 RIPK2 RIPK2 CSNK1G3 CSNK1G3 MAP2K4 MAP2K4 ADAMTSL3 ADAMTSL3 MSH2 MSH2 TRIO TRIO NEXMIF NEXMIF GHR GHR MK-2206 MK-2206 EIF4A1 EIF4A1 PNCK PNCK FASN FASN KIT KIT Dexamethasone Dexamethasone CASK CASK FN1 FN1 MPL MPL CHEK2 CHEK2 MAPK4 MAPK4 EPHA6 EPHA6 DBF4 DBF4 DNAAF3 DNAAF3 NRAS NRAS RPGRIP1 RPGRIP1 Ubistatin B Ubistatin B MSMB MSMB PIKFYVE PIKFYVE ISG15 ISG15 MYB MYB SMAD4 SMAD4 RHPN2 RHPN2 FLNB FLNB TGFBR1 TGFBR1 BRD4354 BRD4354 KALRN KALRN PRIMA-1MET PRIMA-1MET TNFAIP3 TNFAIP3 HSP90AA1 HSP90AA1 BMP4 BMP4 TET2 TET2 TGX-115 TGX-115 RANBP17 RANBP17 ERBB2 ERBB2 BTRC BTRC BMI1 BMI1 CLTCL1 CLTCL1 PML PML PSIP1 PSIP1 CDH2 CDH2 MLLT1 MLLT1 ITGA5 ITGA5 NEK4 NEK4 DCLK1 DCLK1 PHKG1 PHKG1 Quinoclamine Quinoclamine Cerulenin Cerulenin LRRC7 LRRC7 CNTN5 CNTN5 TRAF6 TRAF6 PRAME PRAME DST DST HRAS HRAS Gossypol Gossypol ISX-9 ISX-9 PIK3R1 PIK3R1 Tivantinib Tivantinib COPS5 COPS5 MALT1 MALT1 PRKX PRKX CDH11 CDH11 ROBO2 ROBO2 Piperlongumine Piperlongumine ITIH6 ITIH6 TRRAP TRRAP NLRP1 NLRP1 CDX2 CDX2 MAP2K1 MAP2K1 PIK3CB PIK3CB NF1 NF1 Selumetinib Selumetinib PROC PROC Kahalalide F Kahalalide F DHDDS DHDDS LNX2 LNX2 PTCH1 PTCH1 BRD4 BRD4 PKN3 PKN3 TNFRSF4 TNFRSF4 Compound 23 citrate Compound 23 citrate PPARD PPARD PKHD1 PKHD1 AFDN AFDN CASP1 CASP1 ITGA10 ITGA10 IL3 IL3 DDX1 DDX1 TANK TANK PDPK1 PDPK1 BIX01294 BIX01294 MIEN1 MIEN1 RARA RARA SERPINB1 SERPINB1 PLPP5 PLPP5 STARD3 STARD3 HSPA4 HSPA4 CSF3 CSF3 Fedratinib Fedratinib ADCK1 ADCK1 NUP98 NUP98 LMTK2 LMTK2 LGR5 LGR5 ARHGEF7 ARHGEF7 MAPK6 MAPK6 SOS1 SOS1 UBR5 UBR5 NR4A3 NR4A3 ERN2 ERN2 RPS6KA2 RPS6KA2 PSKH1 PSKH1 MAPK14 MAPK14 MLKL MLKL STK17B STK17B Sepantronium Sepantronium CCNE1 CCNE1 RORA RORA Compound 110 Compound 110 PXDN PXDN FBXW7 FBXW7 FMO4 FMO4 LATS1 LATS1 KSR2 KSR2 Ciclosporin Ciclosporin KDM5A KDM5A NTRK3 NTRK3 PX 12 PX 12 KPNA5 KPNA5 NOTCH1 NOTCH1 OBSCN OBSCN ORMDL3 ORMDL3 NYNRIN NYNRIN IL6ST IL6ST ATP13A5 ATP13A5 TAF1L TAF1L ELAVL1 ELAVL1 SB225002 SB225002 YWHAH YWHAH POU5F1B POU5F1B CDK7 CDK7 GRK6 GRK6 GPHN GPHN RIPK4 RIPK4 Austocystin D Austocystin D ITPR1 ITPR1 CDK19 CDK19 RFC4 RFC4 GLI2 GLI2 ULK4 ULK4 PLCG2 PLCG2 RAP1GDS1 RAP1GDS1 PPP3CA PPP3CA VCPIP1 VCPIP1 ALPK2 ALPK2 PLCG1 PLCG1 ITPR2 ITPR2 BX-795 BX-795 RBM15 RBM15 TSC2 TSC2 MAP2K3 MAP2K3 FANCM FANCM Chaetocin Chaetocin STK40 STK40 PIP5K1B PIP5K1B CMC4 CMC4 RPTOR RPTOR FRK FRK GRIA3 GRIA3 CYTOCHALASIN B CYTOCHALASIN B CLPTM1L CLPTM1L SETDB1 SETDB1 LMO2 LMO2 AXIN2 AXIN2 GRAMD1B GRAMD1B HIPK3 HIPK3 STAT5A STAT5A ADAMTS2 ADAMTS2 PEAK1 PEAK1 HORMAD1 HORMAD1 SCHEMBL2608041 SCHEMBL2608041 STAT3 STAT3 KCNH2 KCNH2 DYRK1A DYRK1A GTSE1 GTSE1 BRIP1 BRIP1 PKDCC PKDCC TP53 TP53 ERN1 ERN1 CIITA CIITA FGFR3 FGFR3 ACVRL1 ACVRL1 HUNK HUNK BMS-754807 BMS-754807 MATK MATK BCL11B BCL11B VPS13B VPS13B SACS SACS STK24 STK24 TCF21 TCF21 NSC95397 NSC95397 MAP3K20 MAP3K20 TAF15 TAF15 ADCK2 ADCK2 TRIM33 TRIM33 Tipifarnib Tipifarnib Simvastatin Simvastatin TRIM67 TRIM67 PIK3C3 PIK3C3 IL21R IL21R FANCE FANCE CHEMBL1434137 CHEMBL1434137 MYO3A MYO3A
Export visualization to SVG Gene-drug targets distribution
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Gene Structure: PDB
