MAP3K11


Summary: The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in MAP3K11


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
CC IBA GO:0005813 centrosome
CC IDA GO:0005813 centrosome
CC IDA GO:0005874 microtubule
CC HDA GO:0016020 membrane
BP IBA GO:0000165 MAPK cascade
BP IMP GO:0000187 activation of MAPK activity
Showing 1 to 6 of 32 rows rows per page

Gene expression in normal tissue: MAP3K11

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAP3K11


Loading, please wait...
Database
Pathway ID
Pathway Des.
wikipathways WP382 MAPK Signaling Pathway
wikipathways WP3879 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression
wikipathways WP3915 Angiopoietin Like Protein 8 Regulatory Pathway
wikipathways WP481 Insulin Signaling
netpath Pathway_TNFalpha TNFalpha
pid cdc42_pathway CDC42 signaling events
Showing 1 to 6 of 24 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD255 SB225002 5
iGMDRD705 Nakiterpiosin 2
iGMDRD506 Fedratinib 2
iGMDRD662 JQ-1 2
Showing 1 to 4 of 8 rows

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAP3K11

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​