MAP3K11

Summary: The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namemitogen-activated protein kinase kinase kinase 11
OMIM IDMIM:600050
Ensembl IDEnsembl:ENSG00000173327
HGNC IDHGNC:HGNC:6850
PHARMGKB IDPA30594
Map Location11q13.1

GO terms in MAP3K11


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IBA GO:0005813 centrosome
CC IDA GO:0005813 centrosome
CC IDA GO:0005874 microtubule
CC HDA GO:0016020 membrane
BP IBA GO:0000165 MAPK cascade
BP IMP GO:0000187 activation of MAPK activity
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Gene expression in normal tissue: MAP3K11

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 6undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 9BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 5

Gene-drug pathway distribution

undefined6Chromatin other1Other, kinases1

Pathways in MAP3K11


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Database
Pathway ID
Pathway Des.
wikipathways WP382 MAPK Signaling Pathway
wikipathways WP3879 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression
wikipathways WP3915 Angiopoietin Like Protein 8 Regulatory Pathway
wikipathways WP481 Insulin Signaling
netpath Pathway_TNFalpha TNFalpha
pid cdc42_pathway CDC42 signaling events
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD255 SB225002 5
iGMDRD705 Nakiterpiosin 2
iGMDRD506 Fedratinib 2
iGMDRD662 JQ-1 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAP3K11

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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