MAP3K11
Summary: The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| mitogen-activated protein kinase kinase kinase 11 | MIM:600050 | Ensembl:ENSG00000173327 | HGNC:HGNC:6850 | PA30594 | 11q13.1 |
GO terms in MAP3K11
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005813 | centrosome |
| CC | IDA | GO:0005813 | centrosome |
| CC | IDA | GO:0005874 | microtubule |
| CC | HDA | GO:0016020 | membrane |
| BP | IBA | GO:0000165 | MAPK cascade |
| BP | IMP | GO:0000187 | activation of MAPK activity |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0007017 | microtubule-based process |
| BP | IMP | GO:0007017 | microtubule-based process |
| BP | TAS | GO:0007254 | JNK cascade |
| BP | IEA | GO:0007256 | activation of JNKK activity |
| BP | IBA | GO:0007257 | activation of JUN kinase activity |
| BP | IMP | GO:0007257 | activation of JUN kinase activity |
| BP | IEA | GO:0008219 | cell death |
| BP | IMP | GO:0008283 | cell proliferation |
| BP | IBA | GO:0043065 | positive regulation of apoptotic process |
| BP | IMP | GO:0043507 | positive regulation of JUN kinase activity |
| BP | IEA | GO:0043525 | positive regulation of neuron apoptotic process |
| BP | IMP | GO:0046330 | positive regulation of JNK cascade |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004706 | JUN kinase kinase kinase activity |
| MF | ISS | GO:0004706 | JUN kinase kinase kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0031434 | mitogen-activated protein kinase kinase binding |
| MF | IPI | GO:0031435 | mitogen-activated protein kinase kinase kinase binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IPI | GO:0042803 | protein homodimerization activity |
| MF | IEA | GO:0048365 | Rac GTPase binding |
Gene expression in normal tissue: MAP3K11
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAP3K11
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3879 | 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP481 | Insulin Signaling |
| netpath | Pathway_TNFalpha | TNFalpha |
| pid | cdc42_pathway | CDC42 signaling events |
| pid | ifngpathway | IFN-gamma pathway |
| pid | rac1_pathway | RAC1 signaling pathway |
| pid | reelinpathway | Reelin signaling pathway |
| pharmgkb | PA165985892 | Tacrolimus/Cyclosporine Pathway, Pharmacodynamics |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) |
| biocarta | mapkpathway | mapkinase signaling pathway |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5673000 | RAF activation |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants |
| reactome | R-HSA-6802949 | Signaling by RAS mutants |
| reactome | R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF |
| reactome | R-HSA-6802957 | Oncogenic MAPK signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD255 | SB225002 | 5 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD662 | JQ-1 | 2 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MAP3K11
CLASSFICATION
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