TRPM7
Summary: This gene belongs to the melastatin subfamily of transient receptor potential family of ion channels. The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. The encoded protein is involved in cytoskeletal organization, cell adhesion, cell migration and organogenesis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. The gene may also be associated with defects of cardiac function. [provided by RefSeq, Aug 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| transient receptor potential cation channel subfamily M member 7 | MIM:605692 | Ensembl:ENSG00000092439 | HGNC:HGNC:17994 | PA38273 | 15q21.2 |
GO terms in TRPM7
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003779 | actin binding |
| MF | IEA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0005262 | calcium channel activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0017022 | myosin binding |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | IEA | GO:0010961 | cellular magnesium ion homeostasis |
| BP | IEA | GO:0016340 | calcium-dependent cell-matrix adhesion |
| BP | IEA | GO:0031032 | actomyosin structure organization |
| BP | IEA | GO:0046777 | protein autophosphorylation |
| BP | IEA | GO:0051262 | protein tetramerization |
| BP | IMP | GO:0070266 | necroptotic process |
| BP | TAS | GO:0070588 | calcium ion transmembrane transport |
| CC | IEA | GO:0001726 | ruffle |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
Gene expression in normal tissue: TRPM7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TRPM7
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04978 | Mineral absorption - Homo sapiens (human) |
| reactome | R-HSA-2672351 | Stimuli-sensing channels |
| reactome | R-HSA-3295583 | TRP channels |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-983712 | Ion channel transport |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD138 | PX 12 | 6 |
| iGMDRD513 | BML-259 | 4 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD698 | Neratinib | 6 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD486 | Tosedostat | 4 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD67 | PENFLURIDOL | 3 |
| iGMDRD329 | Merck60 | 1 |
| iGMDRD552 | AZD-1775 | 6 |
| iGMDRD263 | AACOCF3 | 6 |
| iGMDRD251 | ML162 | 3 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD202 | Curcumin | 6 |
| iGMDRD5 | Tyrphostin AG 1478 | 6 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD289 | Parthenolide | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TRPM7
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