Summary: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq, Jul 2008].

toll like receptor 3MIM:603029Ensembl:ENSG00000164342HGNC:HGNC:11849PA365514q35.1

GO terms in TLR3

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0003725double-stranded RNA binding
MFIDAGO:0003725double-stranded RNA binding
MFNASGO:0003725double-stranded RNA binding
MFNASGO:0004888transmembrane signaling receptor activity
MFIPIGO:0005515protein binding
MFTASGO:0038023signaling receptor activity
MFIPIGO:0042802identical protein binding
CCTASGO:0000139Golgi membrane
CCHDAGO:0005765lysosomal membrane
CCIEAGO:0005769early endosome
CCTASGO:0005789endoplasmic reticulum membrane
CCTASGO:0005887integral component of plasma membrane
CCIDAGO:0009986cell surface
CCTASGO:0010008endosome membrane
CCTASGO:0036020endolysosome membrane
BPIEAGO:0001774microglial cell activation
BPIBAGO:0002224toll-like receptor signaling pathway
BPTASGO:0002224toll-like receptor signaling pathway
BPIEAGO:0002730regulation of dendritic cell cytokine production
BPTASGO:0002756MyD88-independent toll-like receptor signaling pathway
BPIEAGO:0006954inflammatory response
BPNASGO:0006972hyperosmotic response
BPTASGO:0007165signal transduction
BPTASGO:0007249I-kappaB kinase/NF-kappaB signaling
BPNASGO:0007250activation of NF-kappaB-inducing kinase activity
BPIDAGO:0007252I-kappaB phosphorylation
BPIEAGO:0008584male gonad development
BPNASGO:0009597detection of virus
BPIMPGO:0010628positive regulation of gene expression
BPIDAGO:0032722positive regulation of chemokine production
BPISSGO:0032728positive regulation of interferon-beta production
BPISSGO:0032735positive regulation of interleukin-12 production
BPIDAGO:0032755positive regulation of interleukin-6 production
BPIDAGO:0032757positive regulation of interleukin-8 production
BPISSGO:0032760positive regulation of tumor necrosis factor production
BPIDAGO:0034123positive regulation of toll-like receptor signaling pathway
BPTASGO:0034128negative regulation of MyD88-independent toll-like receptor signaling pathway
BPTASGO:0034138toll-like receptor 3 signaling pathway
BPIEAGO:0034346positive regulation of type III interferon production
BPIEAGO:0035458cellular response to interferon-beta
BPTASGO:0035666TRIF-dependent toll-like receptor signaling pathway
BPIEAGO:0035690cellular response to drug
BPTASGO:0042742defense response to bacterium
BPIEAGO:0043065positive regulation of apoptotic process
BPIEAGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPIDAGO:0043330response to exogenous dsRNA
BPIBAGO:0043331response to dsRNA
BPIDAGO:0045078positive regulation of interferon-gamma biosynthetic process
BPIEAGO:0045080positive regulation of chemokine biosynthetic process
BPTASGO:0045087innate immune response
BPIDAGO:0045356positive regulation of interferon-alpha biosynthetic process
BPIDAGO:0045359positive regulation of interferon-beta biosynthetic process
BPIMPGO:0045359positive regulation of interferon-beta biosynthetic process
BPNASGO:0045671negative regulation of osteoclast differentiation
BPIEAGO:0045766positive regulation of angiogenesis
BPISSGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0046330positive regulation of JNK cascade
BPICGO:0050729positive regulation of inflammatory response
BPIEAGO:0051092positive regulation of NF-kappaB transcription factor activity
BPIBAGO:0051607defense response to virus
BPTASGO:0051607defense response to virus
BPTASGO:0070266necroptotic process
BPIEPGO:0071260cellular response to mechanical stimulus
BPIEAGO:0071346cellular response to interferon-gamma
BPIEAGO:0071360cellular response to exogenous dsRNA
BPTASGO:0097190apoptotic signaling pathway
BPIDAGO:0097191extrinsic apoptotic signaling pathway
BPIDAGO:0097527necroptotic signaling pathway
BPIDAGO:1901224positive regulation of NIK/NF-kappaB signaling

Gene expression in normal tissue: TLR3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TLR3

DatabasePathway IDPathway Des.
reactomeR-HSA-1606322ZBP1(DAI) mediated induction of type I IFNs
reactomeR-HSA-166016Toll Like Receptor 4 (TLR4) Cascade
reactomeR-HSA-166166MyD88-independent TLR4 cascade
reactomeR-HSA-1679131Trafficking and processing of endosomal TLR
reactomeR-HSA-168138Toll Like Receptor 9 (TLR9) Cascade
reactomeR-HSA-168164Toll Like Receptor 3 (TLR3) Cascade
reactomeR-HSA-168181Toll Like Receptor 7/8 (TLR7/8) Cascade
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168898Toll-Like Receptors Cascades
reactomeR-HSA-168927TICAM1, RIP1-mediated IKK complex recruitment
reactomeR-HSA-1810476RIP-mediated NFkB activation via ZBP1
reactomeR-HSA-1834949Cytosolic sensors of pathogen-associated DNA
reactomeR-HSA-5260271Diseases of Immune System
reactomeR-HSA-5602358Diseases associated with the TLR signaling cascade
reactomeR-HSA-5602410TLR3 deficiency - HSE
reactomeR-HSA-5602415UNC93B1 deficiency - HSE
reactomeR-HSA-5602566TICAM1 deficiency - HSE
reactomeR-HSA-5602571TRAF3 deficiency - HSE
reactomeR-HSA-9013957TLR3-mediated TICAM1-dependent programmed cell death
reactomeR-HSA-9013973TICAM1-dependent activation of IRF3/IRF7
reactomeR-HSA-9014325TICAM1,TRAF6-dependent induction of TAK1 complex
reactomeR-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling
reactomeR-HSA-937072TRAF6-mediated induction of TAK1 complex within TLR4 complex
reactomeR-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
reactomeR-HSA-975155MyD88 dependent cascade initiated on endosome
reactomeR-HSA-975163IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
biocartatollpathwaytoll-like receptor pathway
kegghsa04217Necroptosis - Homo sapiens (human)
kegghsa04620Toll-like receptor signaling pathway - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05168Herpes simplex infection - Homo sapiens (human)
pidtoll_endogenous_pathwayEndogenous TLR signaling
wikipathwaysWP1449Regulation of toll-like receptor signaling pathway
wikipathwaysWP3858Toll-like Receptor Signaling
wikipathwaysWP4136Fibrin Complement Receptor 3 Signaling Pathway
wikipathwaysWP75Toll-like Receptor Signaling Pathway

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD886Compound 1541A2
iGMDRD5Tyrphostin AG 14783
iGMDRD584VER 1550081

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TLR3