TLR3
Summary: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| toll like receptor 3 | MIM:603029 | Ensembl:ENSG00000164342 | HGNC:HGNC:11849 | PA36551 | 4q35.1 |
GO terms in TLR3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0003725 | double-stranded RNA binding |
| MF | IDA | GO:0003725 | double-stranded RNA binding |
| MF | NAS | GO:0003725 | double-stranded RNA binding |
| MF | NAS | GO:0004888 | transmembrane signaling receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0038023 | signaling receptor activity |
| MF | IPI | GO:0042802 | identical protein binding |
| CC | TAS | GO:0000139 | Golgi membrane |
| CC | IDA | GO:0005622 | intracellular |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | HDA | GO:0005765 | lysosomal membrane |
| CC | IEA | GO:0005769 | early endosome |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | IDA | GO:0009986 | cell surface |
| CC | TAS | GO:0010008 | endosome membrane |
| CC | NAS | GO:0016020 | membrane |
| CC | TAS | GO:0036020 | endolysosome membrane |
| BP | IEA | GO:0001774 | microglial cell activation |
| BP | IBA | GO:0002224 | toll-like receptor signaling pathway |
| BP | TAS | GO:0002224 | toll-like receptor signaling pathway |
| BP | IEA | GO:0002730 | regulation of dendritic cell cytokine production |
| BP | TAS | GO:0002756 | MyD88-independent toll-like receptor signaling pathway |
| BP | IEA | GO:0006954 | inflammatory response |
| BP | NAS | GO:0006972 | hyperosmotic response |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007249 | I-kappaB kinase/NF-kappaB signaling |
| BP | NAS | GO:0007250 | activation of NF-kappaB-inducing kinase activity |
| BP | IDA | GO:0007252 | I-kappaB phosphorylation |
| BP | IEA | GO:0008584 | male gonad development |
| BP | NAS | GO:0009597 | detection of virus |
| BP | IMP | GO:0010628 | positive regulation of gene expression |
| BP | IDA | GO:0032722 | positive regulation of chemokine production |
| BP | ISS | GO:0032728 | positive regulation of interferon-beta production |
| BP | ISS | GO:0032735 | positive regulation of interleukin-12 production |
| BP | IDA | GO:0032755 | positive regulation of interleukin-6 production |
| BP | IDA | GO:0032757 | positive regulation of interleukin-8 production |
| BP | ISS | GO:0032760 | positive regulation of tumor necrosis factor production |
| BP | IDA | GO:0034123 | positive regulation of toll-like receptor signaling pathway |
| BP | TAS | GO:0034128 | negative regulation of MyD88-independent toll-like receptor signaling pathway |
| BP | TAS | GO:0034138 | toll-like receptor 3 signaling pathway |
| BP | IEA | GO:0034346 | positive regulation of type III interferon production |
| BP | IEA | GO:0035458 | cellular response to interferon-beta |
| BP | TAS | GO:0035666 | TRIF-dependent toll-like receptor signaling pathway |
| BP | IEA | GO:0035690 | cellular response to drug |
| BP | TAS | GO:0042742 | defense response to bacterium |
| BP | IEA | GO:0043065 | positive regulation of apoptotic process |
| BP | IEA | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IDA | GO:0043330 | response to exogenous dsRNA |
| BP | IBA | GO:0043331 | response to dsRNA |
| BP | IDA | GO:0045078 | positive regulation of interferon-gamma biosynthetic process |
| BP | IEA | GO:0045080 | positive regulation of chemokine biosynthetic process |
| BP | TAS | GO:0045087 | innate immune response |
| BP | IDA | GO:0045356 | positive regulation of interferon-alpha biosynthetic process |
| BP | IDA | GO:0045359 | positive regulation of interferon-beta biosynthetic process |
| BP | IMP | GO:0045359 | positive regulation of interferon-beta biosynthetic process |
| BP | NAS | GO:0045671 | negative regulation of osteoclast differentiation |
| BP | IEA | GO:0045766 | positive regulation of angiogenesis |
| BP | ISS | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0046330 | positive regulation of JNK cascade |
| BP | IC | GO:0050729 | positive regulation of inflammatory response |
| BP | IEA | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IBA | GO:0051607 | defense response to virus |
| BP | TAS | GO:0051607 | defense response to virus |
| BP | TAS | GO:0070266 | necroptotic process |
| BP | IEP | GO:0071260 | cellular response to mechanical stimulus |
| BP | IEA | GO:0071346 | cellular response to interferon-gamma |
| BP | IEA | GO:0071360 | cellular response to exogenous dsRNA |
| BP | TAS | GO:0097190 | apoptotic signaling pathway |
| BP | IDA | GO:0097191 | extrinsic apoptotic signaling pathway |
| BP | IDA | GO:0097527 | necroptotic signaling pathway |
| BP | IDA | GO:1901224 | positive regulation of NIK/NF-kappaB signaling |
Gene expression in normal tissue: TLR3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TLR3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-1679131 | Trafficking and processing of endosomal TLR |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment |
| reactome | R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 |
| reactome | R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA |
| reactome | R-HSA-5260271 | Diseases of Immune System |
| reactome | R-HSA-5602358 | Diseases associated with the TLR signaling cascade |
| reactome | R-HSA-5602410 | TLR3 deficiency - HSE |
| reactome | R-HSA-5602415 | UNC93B1 deficiency - HSE |
| reactome | R-HSA-5602566 | TICAM1 deficiency - HSE |
| reactome | R-HSA-5602571 | TRAF3 deficiency - HSE |
| reactome | R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death |
| reactome | R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 |
| reactome | R-HSA-9014325 | TICAM1,TRAF6-dependent induction of TAK1 complex |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
| reactome | R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex |
| reactome | R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| reactome | R-HSA-975155 | MyD88 dependent cascade initiated on endosome |
| reactome | R-HSA-975163 | IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| biocarta | tollpathway | toll-like receptor pathway |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa04620 | Toll-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
| pid | toll_endogenous_pathway | Endogenous TLR signaling |
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP3858 | Toll-like Receptor Signaling |
| wikipathways | WP4136 | Fibrin Complement Receptor 3 Signaling Pathway |
| wikipathways | WP75 | Toll-like Receptor Signaling Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD562 | Navitoclax | 5 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD366 | PI-103 | 4 |
| iGMDRD577 | BIX01294 | 4 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD188 | Piperlongumine | 6 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD202 | Curcumin | 1 |
| iGMDRD158 | NSC141540 | 1 |
| iGMDRD434 | BMS-536924 | 6 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD579 | PF750 | 1 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD584 | VER 155008 | 1 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD560 | MK-2206 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TLR3
CLASSFICATION
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