CAMK2A


Summary: The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2018].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in CAMK2A


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Term Type
Evidence Type
GO Term ID
GO Des.
MF ISS GO:0004674 protein serine/threonine kinase activity
MF TAS GO:0004674 protein serine/threonine kinase activity
MF IBA GO:0004683 calmodulin-dependent protein kinase activity
MF IMP GO:0004683 calmodulin-dependent protein kinase activity
MF TAS GO:0005088 Ras guanyl-nucleotide exchange factor activity
MF IPI GO:0005515 protein binding
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Gene expression in normal tissue: CAMK2A

Gene-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 3

Gene-drug pathway distribution

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Pathways in CAMK2A


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Database
Pathway ID
Pathway Des.
pharmgkb PA162356267 EGFR Inhibitor Pathway, Pharmacodynamics
pid fgf_pathway FGF signaling pathway
pid ifngpathway IFN-gamma pathway
pid netrin_pathway Netrin-mediated signaling events
pid pi3kplctrkpathway Trk receptor signaling mediated by PI3K and PLC-gamma
pid tgfbrpathway TGF-beta receptor signaling
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD255 SB225002 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CAMK2A

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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