Summary: The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2018].

calcium/calmodulin dependent protein kinase II alphaMIM:114078Ensembl:ENSG00000070808HGNC:HGNC:1460PA905q32

GO terms in CAMK2A

Term TypeEvidence TypeGO Term IDGO Des.
MFISSGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFIBAGO:0004683calmodulin-dependent protein kinase activity
MFIMPGO:0004683calmodulin-dependent protein kinase activity
MFTASGO:0005088Ras guanyl-nucleotide exchange factor activity
MFIPIGO:0005515protein binding
MFIBAGO:0005516calmodulin binding
MFIPIGO:0005516calmodulin binding
MFIEAGO:0005524ATP binding
MFIMPGO:0009931calcium-dependent protein serine/threonine kinase activity
MFIDAGO:0016301kinase activity
MFISSGO:0035254glutamate receptor binding
MFIPIGO:0042802identical protein binding
MFIPIGO:0042803protein homodimerization activity
MFIEAGO:0046872metal ion binding
BPISSGO:0000082G1/S transition of mitotic cell cycle
BPTASGO:0000165MAPK cascade
BPISSGO:0002931response to ischemia
BPIDAGO:0006468protein phosphorylation
BPIMPGO:0006468protein phosphorylation
BPISSGO:0006816calcium ion transport
BPTASGO:0007223Wnt signaling pathway, calcium modulating pathway
BPISSGO:0010666positive regulation of cardiac muscle cell apoptotic process
BPISSGO:0018105peptidyl-serine phosphorylation
BPIDAGO:0038166angiotensin-activated signaling pathway
BPISSGO:0046777protein autophosphorylation
BPISSGO:0046928regulation of neurotransmitter secretion
BPISSGO:0048168regulation of neuronal synaptic plasticity
BPIEAGO:0048813dendrite morphogenesis
BPIMPGO:0051092positive regulation of NF-kappaB transcription factor activity
BPISSGO:0051928positive regulation of calcium ion transport
BPTASGO:0060333interferon-gamma-mediated signaling pathway
BPISSGO:1902108regulation of mitochondrial membrane permeability involved in apoptotic process
CCTASGO:0005886plasma membrane
CCIEAGO:0014069postsynaptic density
CCIEAGO:0030054cell junction
CCTASGO:0030666endocytic vesicle membrane
CCIEAGO:0042734presynaptic membrane
CCIBAGO:0043005neuron projection

Gene expression in normal tissue: CAMK2A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CAMK2A

DatabasePathway IDPathway Des.
pharmgkbPA162356267EGFR Inhibitor Pathway, Pharmacodynamics
pidfgf_pathwayFGF signaling pathway
pidifngpathwayIFN-gamma pathway
pidnetrin_pathwayNetrin-mediated signaling events
pidpi3kplctrkpathwayTrk receptor signaling mediated by PI3K and PLC-gamma
pidtgfbrpathwayTGF-beta receptor signaling
pidwnt_noncanonical_pathwayNoncanonical Wnt signaling pathway
kegghsa04012ErbB signaling pathway - Homo sapiens (human)
kegghsa04020Calcium signaling pathway - Homo sapiens (human)
kegghsa04024cAMP signaling pathway - Homo sapiens (human)
kegghsa04066HIF-1 signaling pathway - Homo sapiens (human)
kegghsa04114Oocyte meiosis - Homo sapiens (human)
kegghsa04217Necroptosis - Homo sapiens (human)
kegghsa04261Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
kegghsa04310Wnt signaling pathway - Homo sapiens (human)
kegghsa04360Axon guidance - Homo sapiens (human)
kegghsa04713Circadian entrainment - Homo sapiens (human)
kegghsa04720Long-term potentiation - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa04725Cholinergic synapse - Homo sapiens (human)
kegghsa04728Dopaminergic synapse - Homo sapiens (human)
kegghsa04740Olfactory transduction - Homo sapiens (human)
kegghsa04750Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
kegghsa04911Insulin secretion - Homo sapiens (human)
kegghsa04912GnRH signaling pathway - Homo sapiens (human)
kegghsa04916Melanogenesis - Homo sapiens (human)
kegghsa04921Oxytocin signaling pathway - Homo sapiens (human)
kegghsa04922Glucagon signaling pathway - Homo sapiens (human)
kegghsa04925Aldosterone synthesis and secretion - Homo sapiens (human)
kegghsa04934Cushing,s syndrome - Homo sapiens (human)
kegghsa04971Gastric acid secretion - Homo sapiens (human)
kegghsa05031Amphetamine addiction - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05214Glioma - Homo sapiens (human)
wikipathwaysWP23B Cell Receptor Signaling Pathway
wikipathwaysWP2355Corticotropin-releasing hormone signaling pathway
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP2636Common Pathways Underlying Drug Addiction
wikipathwaysWP289Myometrial Relaxation and Contraction Pathways
wikipathwaysWP3298Melatonin metabolism and effects
wikipathwaysWP3584MECP2 and Associated Rett Syndrome
wikipathwaysWP4008NO-cGMP-PKG mediated Neuroprotection
wikipathwaysWP428Wnt Signaling Pathway
wikipathwaysWP437EGF-EGFR Signaling Pathway
wikipathwaysWP536Calcium Regulation in the Cardiac Cell
wikipathwaysWP673ErbB Signaling Pathway
reactomeR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmission
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168256Immune System
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-3371556Cellular response to heat stress
reactomeR-HSA-3371571HSF1-dependent transactivation
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-3858494Beta-catenin independent WNT signaling
reactomeR-HSA-397014Muscle contraction
reactomeR-HSA-399719Trafficking of AMPA receptors
reactomeR-HSA-399721Glutamate binding, activation of AMPA receptors and synaptic plasticity
reactomeR-HSA-4086398Ca2+ pathway
reactomeR-HSA-438064Post NMDA receptor activation events
reactomeR-HSA-438066Unblocking of NMDA receptor, glutamate binding and activation
reactomeR-HSA-442729CREB phosphorylation through the activation of CaMKII
reactomeR-HSA-442742CREB phosphorylation through the activation of Ras
reactomeR-HSA-442755Activation of NMDA receptor and postsynaptic events
reactomeR-HSA-442982Ras activation upon Ca2+ influx through NMDA receptor
reactomeR-HSA-5576891Cardiac conduction
reactomeR-HSA-5576892Phase 0 - rapid depolarisation
reactomeR-HSA-5578775Ion homeostasis
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-877300Interferon gamma signaling
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-913531Interferon Signaling
reactomeR-HSA-936837Ion transport by P-type ATPases
reactomeR-HSA-983712Ion channel transport
biocartabiopeptidespathwaybioactive peptide induced signaling pathway
biocartacacampathwayca-calmodulin-dependent protein kinase activation
biocartacrebpathwaytranscription factor creb and its extracellular signals
biocartapgc1apathwayregulation of pgc-1a
biocartastathminpathwaystathmin and breast cancer resistance to antimicrotubule agents

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CAMK2A