CAMK2A
Summary: The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2018].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| calcium/calmodulin dependent protein kinase II alpha | MIM:114078 | Ensembl:ENSG00000070808 | HGNC:HGNC:1460 | PA90 | 5q32 |
GO terms in CAMK2A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004683 | calmodulin-dependent protein kinase activity |
| MF | IMP | GO:0004683 | calmodulin-dependent protein kinase activity |
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0005516 | calmodulin binding |
| MF | IPI | GO:0005516 | calmodulin binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IMP | GO:0009931 | calcium-dependent protein serine/threonine kinase activity |
| MF | IDA | GO:0016301 | kinase activity |
| MF | ISS | GO:0035254 | glutamate receptor binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IPI | GO:0042803 | protein homodimerization activity |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | ISS | GO:0000082 | G1/S transition of mitotic cell cycle |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | ISS | GO:0002931 | response to ischemia |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IMP | GO:0006468 | protein phosphorylation |
| BP | ISS | GO:0006816 | calcium ion transport |
| BP | TAS | GO:0007223 | Wnt signaling pathway, calcium modulating pathway |
| BP | ISS | GO:0010666 | positive regulation of cardiac muscle cell apoptotic process |
| BP | ISS | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IDA | GO:0038166 | angiotensin-activated signaling pathway |
| BP | ISS | GO:0046777 | protein autophosphorylation |
| BP | ISS | GO:0046928 | regulation of neurotransmitter secretion |
| BP | ISS | GO:0048168 | regulation of neuronal synaptic plasticity |
| BP | IEA | GO:0048813 | dendrite morphogenesis |
| BP | IMP | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | ISS | GO:0051928 | positive regulation of calcium ion transport |
| BP | TAS | GO:0060333 | interferon-gamma-mediated signaling pathway |
| BP | ISS | GO:1902108 | regulation of mitochondrial membrane permeability involved in apoptotic process |
| CC | HDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005739 | mitochondrion |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0014069 | postsynaptic density |
| CC | IEA | GO:0030054 | cell junction |
| CC | TAS | GO:0030666 | endocytic vesicle membrane |
| CC | IEA | GO:0042734 | presynaptic membrane |
| CC | IBA | GO:0043005 | neuron projection |
Gene expression in normal tissue: CAMK2A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CAMK2A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pharmgkb | PA162356267 | EGFR Inhibitor Pathway, Pharmacodynamics |
| pid | fgf_pathway | FGF signaling pathway |
| pid | ifngpathway | IFN-gamma pathway |
| pid | netrin_pathway | Netrin-mediated signaling events |
| pid | pi3kplctrkpathway | Trk receptor signaling mediated by PI3K and PLC-gamma |
| pid | tgfbrpathway | TGF-beta receptor signaling |
| pid | wnt_noncanonical_pathway | Noncanonical Wnt signaling pathway |
| kegg | hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| kegg | hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| kegg | hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04114 | Oocyte meiosis - Homo sapiens (human) |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa04261 | Adrenergic signaling in cardiomyocytes - Homo sapiens (human) |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| kegg | hsa04713 | Circadian entrainment - Homo sapiens (human) |
| kegg | hsa04720 | Long-term potentiation - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa04725 | Cholinergic synapse - Homo sapiens (human) |
| kegg | hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| kegg | hsa04740 | Olfactory transduction - Homo sapiens (human) |
| kegg | hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
| kegg | hsa04911 | Insulin secretion - Homo sapiens (human) |
| kegg | hsa04912 | GnRH signaling pathway - Homo sapiens (human) |
| kegg | hsa04916 | Melanogenesis - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa04922 | Glucagon signaling pathway - Homo sapiens (human) |
| kegg | hsa04925 | Aldosterone synthesis and secretion - Homo sapiens (human) |
| kegg | hsa04934 | Cushing,s syndrome - Homo sapiens (human) |
| kegg | hsa04971 | Gastric acid secretion - Homo sapiens (human) |
| kegg | hsa05031 | Amphetamine addiction - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05214 | Glioma - Homo sapiens (human) |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP2355 | Corticotropin-releasing hormone signaling pathway |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP2636 | Common Pathways Underlying Drug Addiction |
| wikipathways | WP289 | Myometrial Relaxation and Contraction Pathways |
| wikipathways | WP3298 | Melatonin metabolism and effects |
| wikipathways | WP3584 | MECP2 and Associated Rett Syndrome |
| wikipathways | WP4008 | NO-cGMP-PKG mediated Neuroprotection |
| wikipathways | WP428 | Wnt Signaling Pathway |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP536 | Calcium Regulation in the Cardiac Cell |
| wikipathways | WP673 | ErbB Signaling Pathway |
| reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-3371556 | Cellular response to heat stress |
| reactome | R-HSA-3371571 | HSF1-dependent transactivation |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-3858494 | Beta-catenin independent WNT signaling |
| reactome | R-HSA-397014 | Muscle contraction |
| reactome | R-HSA-399719 | Trafficking of AMPA receptors |
| reactome | R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity |
| reactome | R-HSA-4086398 | Ca2+ pathway |
| reactome | R-HSA-438064 | Post NMDA receptor activation events |
| reactome | R-HSA-438066 | Unblocking of NMDA receptor, glutamate binding and activation |
| reactome | R-HSA-442729 | CREB phosphorylation through the activation of CaMKII |
| reactome | R-HSA-442742 | CREB phosphorylation through the activation of Ras |
| reactome | R-HSA-442755 | Activation of NMDA receptor and postsynaptic events |
| reactome | R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor |
| reactome | R-HSA-5576891 | Cardiac conduction |
| reactome | R-HSA-5576892 | Phase 0 - rapid depolarisation |
| reactome | R-HSA-5578775 | Ion homeostasis |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-877300 | Interferon gamma signaling |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-913531 | Interferon Signaling |
| reactome | R-HSA-936837 | Ion transport by P-type ATPases |
| reactome | R-HSA-983712 | Ion channel transport |
| biocarta | biopeptidespathway | bioactive peptide induced signaling pathway |
| biocarta | cacampathway | ca-calmodulin-dependent protein kinase activation |
| biocarta | crebpathway | transcription factor creb and its extracellular signals |
| biocarta | pgc1apathway | regulation of pgc-1a |
| biocarta | stathminpathway | stathmin and breast cancer resistance to antimicrotubule agents |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CAMK2A
CLASSFICATION
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