PORCN

Summary: This gene belongs to the evolutionarily conserved porcupine (Porc) gene family. Genes of the porcupine family encode endoplasmic reticulum proteins with multiple transmembrane domains. Porcupine proteins are involved in the processing of Wnt (wingless and int homologue) proteins. Disruption of this gene is associated with focal dermal hypoplasia, and the encoded protein has been implicated in cancer. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Aug 2013].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameporcupine O-acyltransferase
OMIM IDMIM:300651
Ensembl IDEnsembl:ENSG00000102312
HGNC IDHGNC:HGNC:17652
PHARMGKB IDPA134906089
Map LocationXp11.23

Gene Categories:

DRUGGABLE GENOME

GO terms in PORCN


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0017147 Wnt-protein binding
MF ISS GO:1990698 palmitoleoyltransferase activity
BP ISS GO:0006497 protein lipidation
BP IEA GO:0009100 glycoprotein metabolic process
BP ISS GO:0016055 Wnt signaling pathway
BP ISS GO:0045234 protein palmitoleylation
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Gene expression in normal tissue: PORCN

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined31Apoptosis regulation2PI3K/MTOR signaling2Longevity regulating pathway1

Pathways in PORCN


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Database
Pathway ID
Pathway Des.
kegg hsa04310 Wnt signaling pathway - Homo sapiens (human)
wikipathways WP428 Wnt Signaling Pathway
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-1643685 Disease
reactome R-HSA-195721 Signaling by WNT
reactome R-HSA-3238698 WNT ligand biogenesis and trafficking
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD882 CIL41 2
iGMDRD367 Ro 28-1675 3
iGMDRD871 BRD6368 2
iGMDRD286 Nsc 632839 4
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PORCN

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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