PORCN
Summary: This gene belongs to the evolutionarily conserved porcupine (Porc) gene family. Genes of the porcupine family encode endoplasmic reticulum proteins with multiple transmembrane domains. Porcupine proteins are involved in the processing of Wnt (wingless and int homologue) proteins. Disruption of this gene is associated with focal dermal hypoplasia, and the encoded protein has been implicated in cancer. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Aug 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| porcupine O-acyltransferase | MIM:300651 | Ensembl:ENSG00000102312 | HGNC:HGNC:17652 | PA134906089 | Xp11.23 |
Gene Categories:
DRUGGABLE GENOMEGO terms in PORCN
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0017147 | Wnt-protein binding |
| MF | ISS | GO:1990698 | palmitoleoyltransferase activity |
| BP | ISS | GO:0006497 | protein lipidation |
| BP | IEA | GO:0009100 | glycoprotein metabolic process |
| BP | ISS | GO:0016055 | Wnt signaling pathway |
| BP | ISS | GO:0045234 | protein palmitoleylation |
| BP | IEA | GO:0060070 | canonical Wnt signaling pathway |
| CC | ISS | GO:0005783 | endoplasmic reticulum |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IEA | GO:0030176 | integral component of endoplasmic reticulum membrane |
| CC | IEA | GO:0032281 | AMPA glutamate receptor complex |
Gene expression in normal tissue: PORCN
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PORCN
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| wikipathways | WP428 | Wnt Signaling Pathway |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-3238698 | WNT ligand biogenesis and trafficking |
| reactome | R-HSA-4791275 | Signaling by WNT in cancer |
| reactome | R-HSA-5340573 | WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD882 | CIL41 | 2 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD286 | Nsc 632839 | 4 |
| iGMDRD366 | PI-103 | 7 |
| iGMDRD329 | Merck60 | 5 |
| iGMDRD271 | Brefeldin A | 2 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD213 | SMR000068650 | 3 |
| iGMDRD481 | Dactolisib | 2 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD154 | NSC23766 | 2 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 2 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD780 | PP-30 | 1 |
| iGMDRD562 | Navitoclax | 4 |
| iGMDRD577 | BIX01294 | 1 |
| iGMDRD888 | Compound 44 | 4 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD524 | ISX-9 | 2 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD255 | SB225002 | 5 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD870 | BRD63610 | 7 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD679 | Bistramide A | 3 |
| iGMDRD554 | CHEMBL1434137 | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD781 | Sirolimus | 4 |
| iGMDRD494 | Neopeltolide | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PORCN
CLASSFICATION
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