SULF1


Summary: This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The enzyme is secreted through the Golgi and is subsequently localized to the cell surface. The expression of this gene may be down-regulated in several types of cancer, including hepatocellular (HCC), ovarian and breast cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
sulfatase 1MIM:610012Ensembl:ENSG00000137573HGNC:HGNC:20391PA1348610228q13.2-q13.3

GO terms in SULF1


Term TypeEvidence TypeGO Term IDGO Des.
BPISSGO:0001822kidney development
BPIDAGO:0001937negative regulation of endothelial cell proliferation
BPISSGO:0002063chondrocyte development
BPISSGO:0003094glomerular filtration
BPIEAGO:0006915apoptotic process
BPISSGO:0010575positive regulation of vascular endothelial growth factor production
BPISSGO:0014846esophagus smooth muscle contraction
BPIDAGO:0016525negative regulation of angiogenesis
BPIDAGO:0030177positive regulation of Wnt signaling pathway
BPIDAGO:0030201heparan sulfate proteoglycan metabolic process
BPNASGO:0030201heparan sulfate proteoglycan metabolic process
BPIMPGO:0030336negative regulation of cell migration
BPIMPGO:0030513positive regulation of BMP signaling pathway
BPISSGO:0032836glomerular basement membrane development
BPISSGO:0035860glial cell-derived neurotrophic factor receptor signaling pathway
BPIMPGO:0040036regulation of fibroblast growth factor receptor signaling pathway
BPIMPGO:0040037negative regulation of fibroblast growth factor receptor signaling pathway
BPISSGO:0040037negative regulation of fibroblast growth factor receptor signaling pathway
BPIDAGO:0048010vascular endothelial growth factor receptor signaling pathway
BPISSGO:0048706embryonic skeletal system development
BPISSGO:0051216cartilage development
BPISSGO:0060348bone development
BPISSGO:0060384innervation
BPISSGO:0060686negative regulation of prostatic bud formation
CCHDAGO:0005615extracellular space
CCIDAGO:0005615extracellular space
CCNASGO:0005615extracellular space
CCIDAGO:0005783endoplasmic reticulum
CCISSGO:0005794Golgi apparatus
CCIEAGO:0005795Golgi stack
CCISSGO:0005886plasma membrane
CCIDAGO:0009986cell surface
CCIDAGO:0045121membrane raft
MFIDAGO:0004065arylsulfatase activity
MFIMPGO:0004065arylsulfatase activity
MFIEAGO:0005509calcium ion binding
MFIDAGO:0008449N-acetylglucosamine-6-sulfatase activity
MFIMPGO:0008449N-acetylglucosamine-6-sulfatase activity

Gene expression in normal tissue: SULF1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SULF1


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD300Tozasertib1
iGMDRD505Pevonedistat3
iGMDRD886Compound 1541A3
iGMDRD246NPC263
iGMDRD367Ro 28-16752
iGMDRD871BRD63687
iGMDRD286Nsc 6328396
iGMDRD414MST-3126
iGMDRD231Importazole2
iGMDRD705Nakiterpiosin5
iGMDRD271Brefeldin A3
iGMDRD121GMX17782
iGMDRD137Indisulam3
iGMDRD251ML1623
iGMDRD883CIL55A3
iGMDRD945ML2143
iGMDRD154NSC237662
iGMDRD123Isoevodiamine3
iGMDRD57Chloropentafluorobenzene2
iGMDRD512nutlin 34
iGMDRD584VER 1550083
iGMDRD23Gossypol6
iGMDRD369TGX-1153
iGMDRD64Parbendazole3
iGMDRD780PP-302
iGMDRD398Sepantronium3
iGMDRD100Zebularine2
iGMDRD399Selumetinib2
iGMDRD30917AAG1
iGMDRD870BRD636105
iGMDRD138PX 123
iGMDRD297Austocystin D2
iGMDRD280CYTOCHALASIN B5
iGMDRD193Fqi13
iGMDRD152179324-69-73
iGMDRD484Pluripotin3
iGMDRD144NSC953973
iGMDRD670ML 2105
iGMDRD889Compound 7d-cis3
iGMDRD554CHEMBL14341372

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SULF1

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