SULF1
Summary: This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The enzyme is secreted through the Golgi and is subsequently localized to the cell surface. The expression of this gene may be down-regulated in several types of cancer, including hepatocellular (HCC), ovarian and breast cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| sulfatase 1 | MIM:610012 | Ensembl:ENSG00000137573 | HGNC:HGNC:20391 | PA134861022 | 8q13.2-q13.3 |
GO terms in SULF1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ISS | GO:0001822 | kidney development |
| BP | IDA | GO:0001937 | negative regulation of endothelial cell proliferation |
| BP | ISS | GO:0002063 | chondrocyte development |
| BP | ISS | GO:0003094 | glomerular filtration |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | ISS | GO:0010575 | positive regulation of vascular endothelial growth factor production |
| BP | ISS | GO:0014846 | esophagus smooth muscle contraction |
| BP | IDA | GO:0016525 | negative regulation of angiogenesis |
| BP | IDA | GO:0030177 | positive regulation of Wnt signaling pathway |
| BP | IDA | GO:0030201 | heparan sulfate proteoglycan metabolic process |
| BP | NAS | GO:0030201 | heparan sulfate proteoglycan metabolic process |
| BP | IMP | GO:0030336 | negative regulation of cell migration |
| BP | IMP | GO:0030513 | positive regulation of BMP signaling pathway |
| BP | ISS | GO:0032836 | glomerular basement membrane development |
| BP | ISS | GO:0035860 | glial cell-derived neurotrophic factor receptor signaling pathway |
| BP | IMP | GO:0040036 | regulation of fibroblast growth factor receptor signaling pathway |
| BP | IMP | GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway |
| BP | ISS | GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway |
| BP | IDA | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| BP | ISS | GO:0048706 | embryonic skeletal system development |
| BP | ISS | GO:0051216 | cartilage development |
| BP | ISS | GO:0060348 | bone development |
| BP | ISS | GO:0060384 | innervation |
| BP | ISS | GO:0060686 | negative regulation of prostatic bud formation |
| CC | HDA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005615 | extracellular space |
| CC | NAS | GO:0005615 | extracellular space |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | ISS | GO:0005794 | Golgi apparatus |
| CC | IEA | GO:0005795 | Golgi stack |
| CC | ISS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0009986 | cell surface |
| CC | IDA | GO:0045121 | membrane raft |
| MF | IDA | GO:0004065 | arylsulfatase activity |
| MF | IMP | GO:0004065 | arylsulfatase activity |
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | IDA | GO:0008449 | N-acetylglucosamine-6-sulfatase activity |
| MF | IMP | GO:0008449 | N-acetylglucosamine-6-sulfatase activity |
Gene expression in normal tissue: SULF1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SULF1
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD300 | Tozasertib | 1 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD871 | BRD6368 | 7 |
| iGMDRD286 | Nsc 632839 | 6 |
| iGMDRD414 | MST-312 | 6 |
| iGMDRD231 | Importazole | 2 |
| iGMDRD705 | Nakiterpiosin | 5 |
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD251 | ML162 | 3 |
| iGMDRD883 | CIL55A | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD154 | NSC23766 | 2 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD512 | nutlin 3 | 4 |
| iGMDRD584 | VER 155008 | 3 |
| iGMDRD23 | Gossypol | 6 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD870 | BRD63610 | 5 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD280 | CYTOCHALASIN B | 5 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD484 | Pluripotin | 3 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD670 | ML 210 | 5 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD554 | CHEMBL1434137 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SULF1
CLASSFICATION
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