SULF1
Summary: This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The enzyme is secreted through the Golgi and is subsequently localized to the cell surface. The expression of this gene may be down-regulated in several types of cancer, including hepatocellular (HCC), ovarian and breast cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Namesulfatase 1 OMIM IDMIM:610012 Ensembl IDEnsembl:ENSG00000137573 HGNC IDHGNC:HGNC:20391 PHARMGKB IDPA134861022 Map Location8q13.2-q13.3 | |||||
GO terms in SULF1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ISS | GO:0001822 | kidney development |
| BP | IDA | GO:0001937 | negative regulation of endothelial cell proliferation |
| BP | ISS | GO:0002063 | chondrocyte development |
| BP | ISS | GO:0003094 | glomerular filtration |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | ISS | GO:0010575 | positive regulation of vascular endothelial growth factor production |
Gene expression in normal tissue: SULF1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SULF1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| No matching records found | ||
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SULF1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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