RPS6KA2


Summary: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains two non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternative splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ribosomal protein S6 kinase A2MIM:601685Ensembl:ENSG00000071242HGNC:HGNC:10431PA348466q27

GO terms in RPS6KA2


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0000287magnesium ion binding
MFTASGO:0004674protein serine/threonine kinase activity
MFIBAGO:0004711ribosomal protein S6 kinase activity
MFIDAGO:0004712protein serine/threonine/tyrosine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFTASGO:0016301kinase activity
BPIEAGO:0006468protein phosphorylation
BPNASGO:0007165signal transduction
BPIDAGO:0008285negative regulation of cell proliferation
BPIDAGO:0043065positive regulation of apoptotic process
BPIDAGO:0045786negative regulation of cell cycle
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005737cytoplasm
CCTASGO:0005829cytosol

Gene expression in normal tissue: RPS6KA2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RPS6KA2


DatabasePathway IDPathway Des.
reactomeR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmission
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-166016Toll Like Receptor 4 (TLR4) Cascade
reactomeR-HSA-166058MyD88:Mal cascade initiated on plasma membrane
reactomeR-HSA-166166MyD88-independent TLR4 cascade
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-168138Toll Like Receptor 9 (TLR9) Cascade
reactomeR-HSA-168142Toll Like Receptor 10 (TLR10) Cascade
reactomeR-HSA-168164Toll Like Receptor 3 (TLR3) Cascade
reactomeR-HSA-168176Toll Like Receptor 5 (TLR5) Cascade
reactomeR-HSA-168179Toll Like Receptor TLR1:TLR2 Cascade
reactomeR-HSA-168181Toll Like Receptor 7/8 (TLR7/8) Cascade
reactomeR-HSA-168188Toll Like Receptor TLR6:TLR2 Cascade
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168898Toll-Like Receptors Cascades
reactomeR-HSA-181438Toll Like Receptor 2 (TLR2) Cascade
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-198725Nuclear Events (kinase and transcription factor activation)
reactomeR-HSA-198753ERK/MAPK targets
reactomeR-HSA-199920CREB phosphorylation
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)
reactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)
reactomeR-HSA-2559583Cellular Senescence
reactomeR-HSA-2559583Cellular Senescence
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-373760L1CAM interactions
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-416476G alpha (q) signalling events
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-437239Recycling pathway of L1
reactomeR-HSA-438064Post NMDA receptor activation events
reactomeR-HSA-442742CREB phosphorylation through the activation of Ras
reactomeR-HSA-442755Activation of NMDA receptor and postsynaptic events
reactomeR-HSA-444257RSK activation
reactomeR-HSA-448424Interleukin-17 signaling
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-450282MAPK targets/ Nuclear events mediated by MAP kinases
reactomeR-HSA-450294MAP kinase activation
reactomeR-HSA-881907Gastrin-CREB signalling pathway via PKC and MAPK
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling
reactomeR-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
reactomeR-HSA-975155MyD88 dependent cascade initiated on endosome
reactomeR-HSA-975871MyD88 cascade initiated on plasma membrane
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04114Oocyte meiosis - Homo sapiens (human)
kegghsa04150mTOR signaling pathway - Homo sapiens (human)
kegghsa04714Thermogenesis - Homo sapiens (human)
kegghsa04720Long-term potentiation - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa04914Progesterone-mediated oocyte maturation - Homo sapiens (human)
kegghsa04931Insulin resistance - Homo sapiens (human)
netpathPathway_EGFR1EGFR1
netpathPathway_LeptinLeptin
netpathPathway_ProlactinProlactin
wikipathwaysWP2037Prolactin Signaling Pathway
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP437EGF-EGFR Signaling Pathway
wikipathwaysWP477Cytoplasmic Ribosomal Proteins
wikipathwaysWP481Insulin Signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD945ML2143
iGMDRD280CYTOCHALASIN B5
iGMDRD536PLX-47201
iGMDRD341Triacsin c3
iGMDRD85Ursolic acid3
iGMDRD546BMS-7548074
iGMDRD47ZM3363721
iGMDRD505Pevonedistat2
iGMDRD369TGX-1153
iGMDRD329Merck608
iGMDRD398Sepantronium6
iGMDRD780PP-302
iGMDRD286Nsc 6328392
iGMDRD871BRD63682
iGMDRD8012,4-dideoxy-DC-45-A23
iGMDRD77Itraconazole2
iGMDRD231Importazole3
iGMDRD705Nakiterpiosin2
iGMDRD207Capsaicin1
iGMDRD782DC-45-A22
iGMDRD434BMS-5369243
iGMDRD271Brefeldin A3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RPS6KA2

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