MAPK6

Summary: The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namemitogen-activated protein kinase 6
OMIM IDMIM:602904
Ensembl IDEnsembl:ENSG00000069956
HGNC IDHGNC:HGNC:6879
PHARMGKB IDPA30624
Map Location15q21.2

GO terms in MAPK6


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IBA GO:0005634 nucleus
CC ISS GO:0005634 nucleus
CC TAS GO:0005654 nucleoplasm
CC IBA GO:0005737 cytoplasm
CC ISS GO:0005737 cytoplasm
CC IDA GO:0005829 cytosol
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Gene expression in normal tissue: MAPK6

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 24BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 8

Gene-drug pathway distribution

undefined9Proteasome1Apoptosis regulation1Other, kinases1ERK MAPK signaling1

Pathways in MAPK6


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Database
Pathway ID
Pathway Des.
wikipathways WP185 Integrin-mediated Cell Adhesion
wikipathways WP26 Signal Transduction of S1P Receptor
wikipathways WP3307 MAPK6-MAPK4 signaling
wikipathways WP3915 Angiopoietin Like Protein 8 Regulatory Pathway
wikipathways WP3931 ESC Pluripotency Pathways
wikipathways WP481 Insulin Signaling
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD782 DC-45-A2 2
iGMDRD138 PX 12 1
iGMDRD889 Compound 7d-cis 2
iGMDRD5 Tyrphostin AG 1478 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAPK6

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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