RARG
Summary: This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| retinoic acid receptor gamma | MIM:180190 | Ensembl:ENSG00000172819 | HGNC:HGNC:9866 | PA34227 | 12q13.13 |
GO terms in RARG
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0000976 | transcription regulatory region sequence-specific DNA binding |
| MF | IBA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | IEA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IBA | GO:0001076 | transcription factor activity, RNA polymerase II transcription factor binding |
| MF | ISS | GO:0003677 | DNA binding |
| MF | IBA | GO:0003700 | DNA-binding transcription factor activity |
| MF | ISS | GO:0003700 | DNA-binding transcription factor activity |
| MF | IEA | GO:0003707 | steroid hormone receptor activity |
| MF | IBA | GO:0003708 | retinoic acid receptor activity |
| MF | IEA | GO:0003708 | retinoic acid receptor activity |
| MF | IBA | GO:0004879 | nuclear receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008134 | transcription factor binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IBA | GO:0030374 | nuclear receptor transcription coactivator activity |
| MF | ISS | GO:0046965 | retinoid X receptor binding |
| MF | IBA | GO:0098531 | transcription factor activity, direct ligand regulated sequence-specific DNA binding |
| CC | IEA | GO:0000790 | nuclear chromatin |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | ISS | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | ISS | GO:0005667 | transcription factor complex |
| CC | NAS | GO:0016021 | integral component of membrane |
| CC | IBA | GO:0090575 | RNA polymerase II transcription factor complex |
| BP | IBA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0001843 | neural tube closure |
| BP | IBA | GO:0001889 | liver development |
| BP | IEA | GO:0002068 | glandular epithelial cell development |
| BP | IEA | GO:0003406 | retinal pigment epithelium development |
| BP | IEA | GO:0003430 | growth plate cartilage chondrocyte growth |
| BP | TAS | GO:0006367 | transcription initiation from RNA polymerase II promoter |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | IBA | GO:0007420 | brain development |
| BP | IBA | GO:0007507 | heart development |
| BP | IEA | GO:0008284 | positive regulation of cell proliferation |
| BP | ISS | GO:0008285 | negative regulation of cell proliferation |
| BP | TAS | GO:0008361 | regulation of cell size |
| BP | IBA | GO:0009755 | hormone-mediated signaling pathway |
| BP | IEA | GO:0009952 | anterior/posterior pattern specification |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IBA | GO:0030855 | epithelial cell differentiation |
| BP | IEA | GO:0031076 | embryonic camera-type eye development |
| BP | IEA | GO:0031641 | regulation of myelination |
| BP | IEA | GO:0032331 | negative regulation of chondrocyte differentiation |
| BP | IBA | GO:0032526 | response to retinoic acid |
| BP | IDA | GO:0032526 | response to retinoic acid |
| BP | IBA | GO:0033993 | response to lipid |
| BP | ISS | GO:0035116 | embryonic hindlimb morphogenesis |
| BP | IEA | GO:0035264 | multicellular organism growth |
| BP | ISS | GO:0043065 | positive regulation of apoptotic process |
| BP | IEA | GO:0043066 | negative regulation of apoptotic process |
| BP | ISS | GO:0043068 | positive regulation of programmed cell death |
| BP | IEA | GO:0043401 | steroid hormone mediated signaling pathway |
| BP | IEA | GO:0045637 | regulation of myeloid cell differentiation |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0048048 | embryonic eye morphogenesis |
| BP | IBA | GO:0048384 | retinoic acid receptor signaling pathway |
| BP | IDA | GO:0048384 | retinoic acid receptor signaling pathway |
| BP | IBA | GO:0048568 | embryonic organ development |
| BP | IBA | GO:0048732 | gland development |
| BP | TAS | GO:0060070 | canonical Wnt signaling pathway |
| BP | IEA | GO:0060324 | face development |
| BP | IBA | GO:0060349 | bone morphogenesis |
| BP | IBA | GO:0060429 | epithelium development |
| BP | IEA | GO:0060534 | trachea cartilage development |
| BP | IEA | GO:0060740 | prostate gland epithelium morphogenesis |
| BP | IEA | GO:0070384 | Harderian gland development |
| BP | IBA | GO:0071300 | cellular response to retinoic acid |
| BP | IEA | GO:0071300 | cellular response to retinoic acid |
| BP | IEA | GO:1990830 | cellular response to leukemia inhibitory factor |
Gene expression in normal tissue: RARG
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RARG
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-383280 | Nuclear Receptor transcription pathway |
| reactome | R-HSA-5362517 | Signaling by Retinoic Acid |
| reactome | R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| reactome | R-HSA-5619507 | Activation of HOX genes during differentiation |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-9006931 | Signaling by Nuclear Receptors |
| pid | retinoic_acid_pathway | Retinoic acid receptors-mediated signaling |
| pid | rxr_vdr_pathway | RXR and RAR heterodimerization with other nuclear receptor |
| wikipathways | WP170 | Nuclear Receptors |
| wikipathways | WP2857 | Mesodermal Commitment Pathway |
| wikipathways | WP299 | Nuclear Receptors in Lipid Metabolism and Toxicity |
| wikipathways | WP716 | Vitamin A and Carotenoid Metabolism |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD105 | Triptolide | 2 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD210 | AC55649 | 1 |
| iGMDRD100 | Zebularine | 1 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD577 | BIX01294 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RARG
CLASSFICATION
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