CASP7
Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| caspase 7 | MIM:601761 | Ensembl:ENSG00000165806 | HGNC:HGNC:1508 | PA26091 | 10q25.3 |
GO terms in CASP7
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004197 | cysteine-type endopeptidase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008233 | peptidase activity |
| MF | TAS | GO:0008234 | cysteine-type peptidase activity |
| MF | IBA | GO:0097153 | cysteine-type endopeptidase activity involved in apoptotic process |
| MF | IMP | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| BP | IDA | GO:0006508 | proteolysis |
| BP | IBA | GO:0006915 | apoptotic process |
| BP | IDA | GO:0006915 | apoptotic process |
| BP | IMP | GO:0072734 | cellular response to staurosporine |
| BP | TAS | GO:0097194 | execution phase of apoptosis |
Gene expression in normal tissue: CASP7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CASP7
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| smpdb | SMP00015 | Glutathione Metabolism |
| smpdb | SMP00143 | 5-Oxoprolinuria |
| smpdb | SMP00183 | Gamma-Glutamyltransferase Deficiency |
| smpdb | SMP00337 | Glutathione Synthetase Deficiency |
| smpdb | SMP00500 | 5-oxoprolinase deficiency |
| smpdb | SMP00501 | Gamma-glutamyl-transpeptidase deficiency |
| wikipathways | WP1433 | Nucleotide-binding Oligomerization Domain (NOD) pathway |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP2036 | TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway |
| wikipathways | WP2059 | Alzheimers Disease |
| wikipathways | WP231 | TNF alpha Signaling Pathway |
| wikipathways | WP2328 | Allograft Rejection |
| wikipathways | WP2371 | Parkinsons Disease Pathway |
| wikipathways | WP2374 | Oncostatin M Signaling Pathway |
| wikipathways | WP2507 | Nanomaterial induced apoptosis |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP2864 | Apoptosis-related network due to altered Notch3 in ovarian cancer |
| wikipathways | WP314 | Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation |
| wikipathways | WP3303 | Rac1-Pak1-p38-MMP-2 pathway |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| wikipathways | WP3646 | Hepatitis C and Hepatocellular Carcinoma |
| wikipathways | WP384 | Apoptosis Modulation by HSP70 |
| wikipathways | WP3853 | ERK Pathway in Huntington,s Disease |
| pid | a6b1_a6b4_integrin_pathway | a6b1 and a6b4 Integrin signaling |
| pid | caspase_pathway | Caspase Cascade in Apoptosis |
| pid | e2f_pathway | E2F transcription factor network |
| pid | hivnefpathway | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04215 | Apoptosis - multiple species - Homo sapiens (human) |
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| kegg | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) |
| kegg | hsa05010 | Alzheimer,s disease - Homo sapiens (human) |
| kegg | hsa05133 | Pertussis - Homo sapiens (human) |
| kegg | hsa05134 | Legionellosis - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_TNFalpha | TNFalpha |
| biocarta | bcellsurvivalpathway | b cell survival pathway |
| biocarta | caspasepathway | caspase cascade in apoptosis |
| biocarta | chemicalpathway | apoptotic signaling in response to dna damage |
| biocarta | deathpathway | induction of apoptosis through dr3 and dr4/5 death receptors |
| biocarta | dnafragmentpathway | apoptotic dna-fragmentation and tissue homeostasis |
| biocarta | faspathway | fas signaling pathway (cd95) |
| biocarta | hivnefpathway | hiv-1 nef: negative effector of fas and tnf |
| biocarta | irespathway | internal ribosome entry pathway |
| biocarta | plk3pathway | regulation of cell cycle progression by plk3 |
| biocarta | tffpathway | trefoil factors initiate mucosal healing |
| biocarta | wnvpathway | west nile virus |
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-109606 | Intrinsic Pathway for Apoptosis |
| reactome | R-HSA-111459 | Activation of caspases through apoptosome-mediated cleavage |
| reactome | R-HSA-111461 | Cytochrome c-mediated apoptotic response |
| reactome | R-HSA-111463 | SMAC binds to IAPs |
| reactome | R-HSA-111464 | SMAC-mediated dissociation of IAP:caspase complexes |
| reactome | R-HSA-111465 | Apoptotic cleavage of cellular proteins |
| reactome | R-HSA-111469 | SMAC-mediated apoptotic response |
| reactome | R-HSA-111471 | Apoptotic factor-mediated response |
| reactome | R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-75153 | Apoptotic execution phase |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD513 | BML-259 | 3 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD366 | PI-103 | 6 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD341 | Triacsin c | 6 |
| iGMDRD505 | Pevonedistat | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CASP7
CLASSFICATION
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