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GRK3

Summary: The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NameG protein-coupled receptor kinase 3 OMIM IDMIM:109636 Ensembl IDEnsembl:ENSG00000100077 HGNC IDHGNC:HGNC:290 PHARMGKB IDPA41 Map Location22q12.1

Gene Categories:

DRUGGABLE GENOME SERINE THREONINE KINASE KINASE

GO terms in GRK3

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	TAS	GO:0004672	protein kinase activity
MF	IEA	GO:0004703	G-protein coupled receptor kinase activity
MF	IEA	GO:0005524	ATP binding
MF	TAS	GO:0047696	beta-adrenergic receptor kinase activity
CC	TAS	GO:0005829	cytosol
CC	TAS	GO:0005886	plasma membrane

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Gene expression in normal tissue: GRK3

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GRK3

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Database	Pathway ID	Pathway Des.
wikipathways	WP2355	Corticotropin-releasing hormone signaling pathway
wikipathways	WP4249	Hedgehog Signaling Pathway
pharmgkb	PA165984799	Diuretics Pathway, Pharmacodynamics
pharmgkb	PA2024	Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
pid	thrombin_par1_pathway	PAR1-mediated thrombin signaling events
pid	txa2pathway	Thromboxane A2 receptor signaling

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD280	CYTOCHALASIN B	2
iGMDRD640	CAY10618	3
iGMDRD394	BX-795	1
iGMDRD329	Merck60	4

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GRK3

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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