GRK3
Summary: The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| G protein-coupled receptor kinase 3 | MIM:109636 | Ensembl:ENSG00000100077 | HGNC:HGNC:290 | PA41 | 22q12.1 |
GO terms in GRK3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | IEA | GO:0004703 | G-protein coupled receptor kinase activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | TAS | GO:0047696 | beta-adrenergic receptor kinase activity |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005886 | plasma membrane |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IDA | GO:0031623 | receptor internalization |
Gene expression in normal tissue: GRK3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GRK3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2355 | Corticotropin-releasing hormone signaling pathway |
| wikipathways | WP4249 | Hedgehog Signaling Pathway |
| pharmgkb | PA165984799 | Diuretics Pathway, Pharmacodynamics |
| pharmgkb | PA2024 | Beta-agonist/Beta-blocker Pathway, Pharmacodynamics |
| pid | thrombin_par1_pathway | PAR1-mediated thrombin signaling events |
| pid | txa2pathway | Thromboxane A2 receptor signaling |
| netpath | Pathway_CRH | CRH |
| netpath | Pathway_IL4 | IL4 |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| kegg | hsa04340 | Hedgehog signaling pathway - Homo sapiens (human) |
| kegg | hsa04724 | Glutamatergic synapse - Homo sapiens (human) |
| kegg | hsa04740 | Olfactory transduction - Homo sapiens (human) |
| kegg | hsa05032 | Morphine addiction - Homo sapiens (human) |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-418555 | G alpha (s) signalling events |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis |
| reactome | R-HSA-8856828 | Clathrin-mediated endocytosis |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD640 | CAY10618 | 3 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD329 | Merck60 | 4 |
| iGMDRD314 | Tanespimycin | 1 |
| iGMDRD797 | ISOX DUAL | 1 |
| iGMDRD201 | SKI II | 1 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD77 | Itraconazole | 1 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD554 | CHEMBL1434137 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GRK3
CLASSFICATION
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