GRK3


Summary: The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
G protein-coupled receptor kinase 3MIM:109636Ensembl:ENSG00000100077HGNC:HGNC:290PA4122q12.1

GO terms in GRK3


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0004672protein kinase activity
MFIEAGO:0004703G-protein coupled receptor kinase activity
MFIEAGO:0005524ATP binding
MFTASGO:0047696beta-adrenergic receptor kinase activity
CCTASGO:0005829cytosol
CCTASGO:0005886plasma membrane
BPIEAGO:0006468protein phosphorylation
BPTASGO:0007165signal transduction
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPIDAGO:0031623receptor internalization

Gene expression in normal tissue: GRK3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GRK3


DatabasePathway IDPathway Des.
wikipathwaysWP2355Corticotropin-releasing hormone signaling pathway
wikipathwaysWP4249Hedgehog Signaling Pathway
pharmgkbPA165984799Diuretics Pathway, Pharmacodynamics
pharmgkbPA2024Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
pidthrombin_par1_pathwayPAR1-mediated thrombin signaling events
pidtxa2pathwayThromboxane A2 receptor signaling
netpathPathway_CRHCRH
netpathPathway_IL4IL4
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa04144Endocytosis - Homo sapiens (human)
kegghsa04340Hedgehog signaling pathway - Homo sapiens (human)
kegghsa04724Glutamatergic synapse - Homo sapiens (human)
kegghsa04740Olfactory transduction - Homo sapiens (human)
kegghsa05032Morphine addiction - Homo sapiens (human)
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-418555G alpha (s) signalling events
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-8856825Cargo recognition for clathrin-mediated endocytosis
reactomeR-HSA-8856828Clathrin-mediated endocytosis

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD280CYTOCHALASIN B2
iGMDRD640CAY106183
iGMDRD394BX-7951
iGMDRD329Merck604
iGMDRD314Tanespimycin1
iGMDRD797ISOX DUAL1
iGMDRD201SKI II1
iGMDRD871BRD63682
iGMDRD188Piperlongumine2
iGMDRD77Itraconazole1
iGMDRD424Tamatinib3
iGMDRD434BMS-5369243
iGMDRD6AM-5803
iGMDRD599Salermide3
iGMDRD554CHEMBL14341371

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GRK3

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