CAMK2D
Summary: The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns.[provided by RefSeq, Nov 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| calcium/calmodulin dependent protein kinase II delta | MIM:607708 | Ensembl:ENSG00000145349 | HGNC:HGNC:1462 | PA92 | 4q26 |
GO terms in CAMK2D
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | ISS | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | HDA | GO:0016020 | membrane |
| CC | TAS | GO:0030666 | endocytic vesicle membrane |
| CC | IEA | GO:0033017 | sarcoplasmic reticulum membrane |
| CC | IEA | GO:0042383 | sarcolemma |
| CC | IBA | GO:0043005 | neuron projection |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | NAS | GO:0001558 | regulation of cell growth |
| BP | TAS | GO:0002026 | regulation of the force of heart contraction |
| BP | IDA | GO:0003254 | regulation of membrane depolarization |
| BP | TAS | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0008016 | regulation of heart contraction |
| BP | IMP | GO:0010613 | positive regulation of cardiac muscle hypertrophy |
| BP | ISS | GO:0010649 | regulation of cell communication by electrical coupling |
| BP | ISS | GO:0010666 | positive regulation of cardiac muscle cell apoptotic process |
| BP | ISS | GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| BP | IC | GO:0010881 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
| BP | TAS | GO:0010881 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
| BP | IDA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IDA | GO:0018107 | peptidyl-threonine phosphorylation |
| BP | ISS | GO:0032469 | endoplasmic reticulum calcium ion homeostasis |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IDA | GO:0051259 | protein complex oligomerization |
| BP | ISS | GO:0055119 | relaxation of cardiac muscle |
| BP | TAS | GO:0060314 | regulation of ryanodine-sensitive calcium-release channel activity |
| BP | TAS | GO:0060333 | interferon-gamma-mediated signaling pathway |
| BP | IMP | GO:0060341 | regulation of cellular localization |
| BP | TAS | GO:0071277 | cellular response to calcium ion |
| BP | ISS | GO:0086003 | cardiac muscle cell contraction |
| BP | IC | GO:0086091 | regulation of heart rate by cardiac conduction |
| BP | ISS | GO:0098901 | regulation of cardiac muscle cell action potential |
| BP | IC | GO:0098909 | regulation of cardiac muscle cell action potential involved in regulation of contraction |
| BP | TAS | GO:1901725 | regulation of histone deacetylase activity |
| BP | IC | GO:1901844 | regulation of cell communication by electrical coupling involved in cardiac conduction |
| BP | IDA | GO:1901897 | regulation of relaxation of cardiac muscle |
| BP | IDA | GO:1902306 | negative regulation of sodium ion transmembrane transport |
| BP | ISS | GO:1902514 | regulation of calcium ion transmembrane transport via high voltage-gated calcium channel |
| BP | IDA | GO:2000650 | negative regulation of sodium ion transmembrane transporter activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004683 | calmodulin-dependent protein kinase activity |
| MF | IDA | GO:0004683 | calmodulin-dependent protein kinase activity |
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0005516 | calmodulin binding |
| MF | IPI | GO:0005516 | calmodulin binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0019871 | sodium channel inhibitor activity |
| MF | IPI | GO:0031432 | titin binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IPI | GO:0042803 | protein homodimerization activity |
| MF | IPI | GO:0044325 | ion channel binding |
| MF | ISS | GO:0044325 | ion channel binding |
Gene expression in normal tissue: CAMK2D
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CAMK2D
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-3371556 | Cellular response to heat stress |
| reactome | R-HSA-3371571 | HSF1-dependent transactivation |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-397014 | Muscle contraction |
| reactome | R-HSA-399719 | Trafficking of AMPA receptors |
| reactome | R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity |
| reactome | R-HSA-438064 | Post NMDA receptor activation events |
| reactome | R-HSA-438066 | Unblocking of NMDA receptor, glutamate binding and activation |
| reactome | R-HSA-442729 | CREB phosphorylation through the activation of CaMKII |
| reactome | R-HSA-442742 | CREB phosphorylation through the activation of Ras |
| reactome | R-HSA-442755 | Activation of NMDA receptor and postsynaptic events |
| reactome | R-HSA-442982 | Ras activation upon Ca2+ influx through NMDA receptor |
| reactome | R-HSA-5576891 | Cardiac conduction |
| reactome | R-HSA-5576892 | Phase 0 - rapid depolarisation |
| reactome | R-HSA-5578775 | Ion homeostasis |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-877300 | Interferon gamma signaling |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-913531 | Interferon Signaling |
| reactome | R-HSA-936837 | Ion transport by P-type ATPases |
| reactome | R-HSA-983712 | Ion channel transport |
| biocarta | biopeptidespathway | bioactive peptide induced signaling pathway |
| biocarta | cacampathway | ca-calmodulin-dependent protein kinase activation |
| biocarta | crebpathway | transcription factor creb and its extracellular signals |
| biocarta | pgc1apathway | regulation of pgc-1a |
| biocarta | stathminpathway | stathmin and breast cancer resistance to antimicrotubule agents |
| pid | hes_heypathway | Notch-mediated HES/HEY network |
| pid | ifngpathway | IFN-gamma pathway |
| pharmgkb | PA162356267 | EGFR Inhibitor Pathway, Pharmacodynamics |
| kegg | hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| kegg | hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| kegg | hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04114 | Oocyte meiosis - Homo sapiens (human) |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa04261 | Adrenergic signaling in cardiomyocytes - Homo sapiens (human) |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| kegg | hsa04713 | Circadian entrainment - Homo sapiens (human) |
| kegg | hsa04720 | Long-term potentiation - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa04725 | Cholinergic synapse - Homo sapiens (human) |
| kegg | hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| kegg | hsa04740 | Olfactory transduction - Homo sapiens (human) |
| kegg | hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
| kegg | hsa04911 | Insulin secretion - Homo sapiens (human) |
| kegg | hsa04912 | GnRH signaling pathway - Homo sapiens (human) |
| kegg | hsa04916 | Melanogenesis - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa04922 | Glucagon signaling pathway - Homo sapiens (human) |
| kegg | hsa04925 | Aldosterone synthesis and secretion - Homo sapiens (human) |
| kegg | hsa04934 | Cushing,s syndrome - Homo sapiens (human) |
| kegg | hsa04971 | Gastric acid secretion - Homo sapiens (human) |
| kegg | hsa05031 | Amphetamine addiction - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05214 | Glioma - Homo sapiens (human) |
| wikipathways | WP1528 | Physiological and Pathological Hypertrophy of the Heart |
| wikipathways | WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
| wikipathways | WP1991 | SRF and miRs in Smooth Muscle Differentiation and Proliferation |
| wikipathways | WP2795 | Cardiac Hypertrophic Response |
| wikipathways | WP289 | Myometrial Relaxation and Contraction Pathways |
| wikipathways | WP4008 | NO-cGMP-PKG mediated Neuroprotection |
| wikipathways | WP428 | Wnt Signaling Pathway |
| wikipathways | WP536 | Calcium Regulation in the Cardiac Cell |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD137 | Indisulam | 6 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD67 | PENFLURIDOL | 3 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD61 | Kinetin riboside | 6 |
| iGMDRD322 | FK 866 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CAMK2D
CLASSFICATION
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