MAPKAPK5


Summary: The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
mitogen-activated protein kinase-activated protein kinase 5MIM:606723Ensembl:ENSG00000089022HGNC:HGNC:6889PA3063312q24.12-q24.13

GO terms in MAPKAPK5


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIBAGO:0005737cytoplasm
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
BPIBAGO:0000165MAPK cascade
BPIEAGO:0000165MAPK cascade
BPIEAGO:0000187activation of MAPK activity
BPIDAGO:0006417regulation of translation
BPTASGO:0007165signal transduction
BPIBAGO:0007166cell surface receptor signaling pathway
BPIBAGO:0007265Ras protein signal transduction
BPIDAGO:0007265Ras protein signal transduction
BPIBAGO:0018105peptidyl-serine phosphorylation
BPISSGO:0032007negative regulation of TOR signaling
BPIMPGO:0032212positive regulation of telomere maintenance via telomerase
BPIBAGO:0035556intracellular signal transduction
BPIBAGO:0046777protein autophosphorylation
BPIDAGO:0046777protein autophosphorylation
BPIMPGO:0051973positive regulation of telomerase activity
BPIDAGO:0090400stress-induced premature senescence
BPTASGO:1901796regulation of signal transduction by p53 class mediator
BPIMPGO:1904355positive regulation of telomere capping
MFIDAGO:0002039p53 binding
MFEXPGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFIBAGO:0004683calmodulin-dependent protein kinase activity
MFTASGO:0004708MAP kinase kinase activity
MFIPIGO:0005515protein binding
MFIBAGO:0005516calmodulin binding
MFIEAGO:0005524ATP binding
MFIBAGO:0009931calcium-dependent protein serine/threonine kinase activity

Gene expression in normal tissue: MAPKAPK5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAPKAPK5


DatabasePathway IDPathway Des.
pidp38alphabetadownstreampathwaySignaling mediated by p38-alpha and p38-beta
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
wikipathwaysWP3307MAPK6-MAPK4 signaling
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP400p38 MAPK Signaling Pathway
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2559580Oxidative Stress Induced Senescence
reactomeR-HSA-2559583Cellular Senescence
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-5633007Regulation of TP53 Activity
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5687128MAPK6/MAPK4 signaling
reactomeR-HSA-6804756Regulation of TP53 Activity through Phosphorylation
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8953897Cellular responses to external stimuli
biocartap38mapkpathwayp38 mapk signaling pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD82Quiflapon1
iGMDRD237ABT-7511
iGMDRD562Navitoclax3
iGMDRD639YK 4-2793
iGMDRD318PAC-13
iGMDRD6AM-5803
iGMDRD148Pifithrin-mu3
iGMDRD772BRD47703
iGMDRD599Salermide3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAPKAPK5

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