MAPKAPK5
Summary: The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| mitogen-activated protein kinase-activated protein kinase 5 | MIM:606723 | Ensembl:ENSG00000089022 | HGNC:HGNC:6889 | PA30633 | 12q24.12-q24.13 |
GO terms in MAPKAPK5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| BP | IBA | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0000187 | activation of MAPK activity |
| BP | IDA | GO:0006417 | regulation of translation |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IBA | GO:0007166 | cell surface receptor signaling pathway |
| BP | IBA | GO:0007265 | Ras protein signal transduction |
| BP | IDA | GO:0007265 | Ras protein signal transduction |
| BP | IBA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | ISS | GO:0032007 | negative regulation of TOR signaling |
| BP | IMP | GO:0032212 | positive regulation of telomere maintenance via telomerase |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | IBA | GO:0046777 | protein autophosphorylation |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IMP | GO:0051973 | positive regulation of telomerase activity |
| BP | IDA | GO:0090400 | stress-induced premature senescence |
| BP | TAS | GO:1901796 | regulation of signal transduction by p53 class mediator |
| BP | IMP | GO:1904355 | positive regulation of telomere capping |
| MF | IDA | GO:0002039 | p53 binding |
| MF | EXP | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004683 | calmodulin-dependent protein kinase activity |
| MF | TAS | GO:0004708 | MAP kinase kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0005516 | calmodulin binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0009931 | calcium-dependent protein serine/threonine kinase activity |
Gene expression in normal tissue: MAPKAPK5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAPKAPK5
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | p38alphabetadownstreampathway | Signaling mediated by p38-alpha and p38-beta |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| wikipathways | WP3307 | MAPK6-MAPK4 signaling |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP400 | p38 MAPK Signaling Pathway |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2559580 | Oxidative Stress Induced Senescence |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5687128 | MAPK6/MAPK4 signaling |
| reactome | R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| biocarta | p38mapkpathway | p38 mapk signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD82 | Quiflapon | 1 |
| iGMDRD237 | ABT-751 | 1 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD599 | Salermide | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MAPKAPK5
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