EPHB3
Summary: Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B family members. [provided by RefSeq, Mar 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| EPH receptor B3 | MIM:601839 | Ensembl:ENSG00000182580 | HGNC:HGNC:3394 | PA27826 | 3q27.1 |
GO terms in EPHB3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ISS | GO:0001525 | angiogenesis |
| BP | ISS | GO:0001655 | urogenital system development |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | ISS | GO:0007411 | axon guidance |
| BP | ISS | GO:0007413 | axonal fasciculation |
| BP | IBA | GO:0009968 | negative regulation of signal transduction |
| BP | IDA | GO:0016477 | cell migration |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IEA | GO:0021952 | central nervous system projection neuron axonogenesis |
| BP | ISS | GO:0022038 | corpus callosum development |
| BP | IDA | GO:0022407 | regulation of cell-cell adhesion |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IEA | GO:0031290 | retinal ganglion cell axon guidance |
| BP | IBA | GO:0033674 | positive regulation of kinase activity |
| BP | IDA | GO:0034446 | substrate adhesion-dependent cell spreading |
| BP | IBA | GO:0043066 | negative regulation of apoptotic process |
| BP | IDA | GO:0043087 | regulation of GTPase activity |
| BP | IBA | GO:0043410 | positive regulation of MAPK cascade |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IDA | GO:0048013 | ephrin receptor signaling pathway |
| BP | TAS | GO:0048013 | ephrin receptor signaling pathway |
| BP | ISS | GO:0048538 | thymus development |
| BP | ISS | GO:0048546 | digestive tract morphogenesis |
| BP | ISS | GO:0050770 | regulation of axonogenesis |
| BP | ISS | GO:0051965 | positive regulation of synapse assembly |
| BP | ISS | GO:0060021 | roof of mouth development |
| BP | ISS | GO:0060996 | dendritic spine development |
| BP | ISS | GO:0060997 | dendritic spine morphogenesis |
| BP | IBA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IDA | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0030425 | dendrite |
| CC | IBA | GO:0043005 | neuron projection |
| CC | IBA | GO:0043235 | receptor complex |
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | EXP | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IBA | GO:0004888 | transmembrane signaling receptor activity |
| MF | IDA | GO:0005003 | ephrin receptor activity |
| MF | IBA | GO:0005005 | transmembrane-ephrin receptor activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0008046 | axon guidance receptor activity |
| MF | IBA | GO:0031434 | mitogen-activated protein kinase kinase binding |
Gene expression in normal tissue: EPHB3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EPHB3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| pid | ephbfwdpathway | EPHB forward signaling |
| netpath | Pathway_EGFR1 | EGFR1 |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-3928662 | EPHB-mediated forward signaling |
| reactome | R-HSA-3928662 | EPHB-mediated forward signaling |
| reactome | R-HSA-3928664 | Ephrin signaling |
| reactome | R-HSA-3928664 | Ephrin signaling |
| reactome | R-HSA-3928665 | EPH-ephrin mediated repulsion of cells |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD268 | Cerulenin | 3 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD690 | PRIMA-1MET | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 3 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD267 | Oligomycin A | 1 |
| iGMDRD213 | SMR000068650 | 3 |
| iGMDRD6 | AM-580 | 6 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD247 | Blebbistatin | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD380 | Pifithrin-alpha | 3 |
| iGMDRD679 | Bistramide A | 3 |
| iGMDRD219 | Bax channel blocker | 3 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD484 | Pluripotin | 3 |
| iGMDRD607 | Ubistatin B | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD425 | ERASTIN | 1 |
| iGMDRD151 | CHM-1 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EPHB3
CLASSFICATION
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