EPHB3
Summary: Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B family members. [provided by RefSeq, Mar 2010].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
NameEPH receptor B3 OMIM IDMIM:601839 Ensembl IDEnsembl:ENSG00000182580 HGNC IDHGNC:HGNC:3394 PHARMGKB IDPA27826 Map Location3q27.1 | |||||
GO terms in EPHB3
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ISS | GO:0001525 | angiogenesis |
| BP | ISS | GO:0001655 | urogenital system development |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | ISS | GO:0007411 | axon guidance |
| BP | ISS | GO:0007413 | axonal fasciculation |
| BP | IBA | GO:0009968 | negative regulation of signal transduction |
Gene expression in normal tissue: EPHB3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EPHB3
Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| pid | ephbfwdpathway | EPHB forward signaling |
| netpath | Pathway_EGFR1 | EGFR1 |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EPHB3
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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