FCRL4
Summary: This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains three immune-receptor tyrosine-based inhibitory motifs. This protein may play a role in the function of memory B-cells in the epithelia. Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and multiple myeloma. [provided by RefSeq, Apr 2009].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:605876 Ensembl IDEnsembl:ENSG00000163518 HGNC IDHGNC:HGNC:18507 PHARMGKB IDPA142671768 Map Location1q23.1 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in FCRL4
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0002250 | adaptive immune response |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0009986 | cell surface |
| CC | IEA | GO:0016021 | integral component of membrane |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: FCRL4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FCRL4
Database | Pathway ID | Pathway Des. |
|---|---|---|
| No matching records found | ||
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FCRL4
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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