FCRL4


Summary: This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains three immune-receptor tyrosine-based inhibitory motifs. This protein may play a role in the function of memory B-cells in the epithelia. Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and multiple myeloma. [provided by RefSeq, Apr 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
Fc receptor like 4MIM:605876Ensembl:ENSG00000163518HGNC:HGNC:18507PA1426717681q23.1

Gene Categories:

DRUGGABLE GENOME

GO terms in FCRL4


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0002250adaptive immune response
CCIEAGO:0005886plasma membrane
CCIDAGO:0009986cell surface
CCIEAGO:0016021integral component of membrane
MFIPIGO:0005515protein binding

Gene expression in normal tissue: FCRL4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FCRL4


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD781Sirolimus4
iGMDRD126Tipifarnib6
iGMDRD579PF7503
iGMDRD889Compound 7d-cis4
iGMDRD280CYTOCHALASIN B4
iGMDRD679Bistramide A4
iGMDRD6AM-5803
iGMDRD441TW 371
iGMDRD121GMX17783
iGMDRD60Quinoclamine5
iGMDRD886Compound 1541A2
iGMDRD322FK 8663
iGMDRD887Compound 23 citrate2
iGMDRD286Nsc 6328394
iGMDRD367Ro 28-16753
iGMDRD871BRD63685
iGMDRD780PP-304

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FCRL4

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