KCNH8


Summary: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
potassium voltage-gated channel subfamily H member 8MIM:608260Ensembl:ENSG00000183960HGNC:HGNC:18864PA387243p24.3

GO terms in KCNH8


Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0005622intracellular
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
BPIEAGO:0000160phosphorelay signal transduction system
BPIEAGO:0023014signal transduction by protein phosphorylation
BPIEAGO:0034765regulation of ion transmembrane transport
BPIBAGO:0042391regulation of membrane potential
BPIBAGO:0071805potassium ion transmembrane transport
BPIEAGO:0071805potassium ion transmembrane transport
MFIEAGO:0000155phosphorelay sensor kinase activity
MFIBAGO:0005249voltage-gated potassium channel activity

Gene expression in normal tissue: KCNH8

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KCNH8


DatabasePathway IDPathway Des.
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-1296071Potassium Channels
reactomeR-HSA-1296072Voltage gated Potassium channels

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011
iGMDRD154NSC237666
iGMDRD211(1S,3R)-RSL33
iGMDRD886Compound 1541A2
iGMDRD297Austocystin D3
iGMDRD246NPC263
iGMDRD562Navitoclax3
iGMDRD366PI-1034
iGMDRD188Piperlongumine2
iGMDRD318PAC-13
iGMDRD226ML0063
iGMDRD6AM-5803
iGMDRD171Pemetrexed3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KCNH8

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