KCNH8
Summary: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| potassium voltage-gated channel subfamily H member 8 | MIM:608260 | Ensembl:ENSG00000183960 | HGNC:HGNC:18864 | PA38724 | 3p24.3 |
GO terms in KCNH8
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0005622 | intracellular |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| BP | IEA | GO:0000160 | phosphorelay signal transduction system |
| BP | IEA | GO:0023014 | signal transduction by protein phosphorylation |
| BP | IEA | GO:0034765 | regulation of ion transmembrane transport |
| BP | IBA | GO:0042391 | regulation of membrane potential |
| BP | IBA | GO:0071805 | potassium ion transmembrane transport |
| BP | IEA | GO:0071805 | potassium ion transmembrane transport |
| MF | IEA | GO:0000155 | phosphorelay sensor kinase activity |
| MF | IBA | GO:0005249 | voltage-gated potassium channel activity |
Gene expression in normal tissue: KCNH8
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KCNH8
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-1296071 | Potassium Channels |
| reactome | R-HSA-1296072 | Voltage gated Potassium channels |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD154 | NSC23766 | 6 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD366 | PI-103 | 4 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD226 | ML006 | 3 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD171 | Pemetrexed | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KCNH8
CLASSFICATION
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