KCNH8

Summary: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namepotassium voltage-gated channel subfamily H member 8
OMIM IDMIM:608260
Ensembl IDEnsembl:ENSG00000183960
HGNC IDHGNC:HGNC:18864
PHARMGKB IDPA38724
Map Location3p24.3

GO terms in KCNH8


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IEA GO:0005622 intracellular
CC IDA GO:0005886 plasma membrane
CC TAS GO:0005886 plasma membrane
CC IBA GO:0005887 integral component of plasma membrane
BP IEA GO:0000160 phosphorelay signal transduction system
BP IEA GO:0023014 signal transduction by protein phosphorylation
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Gene expression in normal tissue: KCNH8

Gene-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 3undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 27BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 9

Gene-drug pathway distribution

Pathways in KCNH8


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Database
Pathway ID
Pathway Des.
reactome R-HSA-112316 Neuronal System
reactome R-HSA-1296071 Potassium Channels
reactome R-HSA-1296072 Voltage gated Potassium channels
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
iGMDRD154 NSC23766 6
iGMDRD211 (1S,3R)-RSL3 3
iGMDRD886 Compound 1541A 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KCNH8

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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