MMP9

Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namematrix metallopeptidase 9
OMIM IDMIM:120361
Ensembl IDEnsembl:ENSG00000100985
HGNC IDHGNC:HGNC:7176
PHARMGKB IDPA30889
Map Location20q13.12

GO terms in MMP9


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Term Type
Evidence Type
GO Term ID
GO Des.
MF EXP GO:0004175 endopeptidase activity
MF IDA GO:0004175 endopeptidase activity
MF IDA GO:0004222 metalloendopeptidase activity
MF TAS GO:0004222 metalloendopeptidase activity
MF EXP GO:0004252 serine-type endopeptidase activity
MF TAS GO:0004252 serine-type endopeptidase activity
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Gene expression in normal tissue: MMP9

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 25OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 7BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: Inflammatory Breast Cancer (IBC) model num: 1

Gene-drug pathway distribution

undefined10Metabolism1Apoptosis regulation1VEGF signaling pathway1

Pathways in MMP9


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Database
Pathway ID
Pathway Des.
wikipathways WP129 Matrix Metalloproteinases
wikipathways WP1434 Osteopontin Signaling
wikipathways WP1539 Angiogenesis
wikipathways WP1993 Angiogenesis overview
wikipathways WP2036 TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway
wikipathways WP2324 AGE-RAGE pathway
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD837 Bevacizumab 1
iGMDRD562 Navitoclax 1
iGMDRD60 Quinoclamine 3
iGMDRD82 Quiflapon 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MMP9

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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