MMP9
Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| matrix metallopeptidase 9 | MIM:120361 | Ensembl:ENSG00000100985 | HGNC:HGNC:7176 | PA30889 | 20q13.12 |
GO terms in MMP9
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | EXP | GO:0004175 | endopeptidase activity |
| MF | IDA | GO:0004175 | endopeptidase activity |
| MF | IDA | GO:0004222 | metalloendopeptidase activity |
| MF | TAS | GO:0004222 | metalloendopeptidase activity |
| MF | EXP | GO:0004252 | serine-type endopeptidase activity |
| MF | TAS | GO:0004252 | serine-type endopeptidase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0005518 | collagen binding |
| MF | IDA | GO:0008237 | metallopeptidase activity |
| MF | TAS | GO:0008270 | zinc ion binding |
| MF | IPI | GO:0042802 | identical protein binding |
| CC | HDA | GO:0005576 | extracellular region |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IDA | GO:0005615 | extracellular space |
| CC | IEA | GO:0031012 | extracellular matrix |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | TAS | GO:1904724 | tertiary granule lumen |
| CC | TAS | GO:1904813 | ficolin-1-rich granule lumen |
| BP | IEA | GO:0001501 | skeletal system development |
| BP | IEA | GO:0001503 | ossification |
| BP | IMP | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IDA | GO:0006508 | proteolysis |
| BP | IEA | GO:0007566 | embryo implantation |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | TAS | GO:0022617 | extracellular matrix disassembly |
| BP | TAS | GO:0030225 | macrophage differentiation |
| BP | TAS | GO:0030335 | positive regulation of cell migration |
| BP | TAS | GO:0030574 | collagen catabolic process |
| BP | IDA | GO:0034614 | cellular response to reactive oxygen species |
| BP | IEP | GO:0035987 | endodermal cell differentiation |
| BP | IMP | GO:0043066 | negative regulation of apoptotic process |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IDA | GO:0043388 | positive regulation of DNA binding |
| BP | IMP | GO:0045742 | positive regulation of epidermal growth factor receptor signaling pathway |
| BP | TAS | GO:0048013 | ephrin receptor signaling pathway |
| BP | IEA | GO:0050900 | leukocyte migration |
| BP | IMP | GO:0051549 | positive regulation of keratinocyte migration |
| BP | IDA | GO:0071276 | cellular response to cadmium ion |
| BP | IMP | GO:0090200 | positive regulation of release of cytochrome c from mitochondria |
| BP | IDA | GO:1900122 | positive regulation of receptor binding |
| BP | IMP | GO:1904707 | positive regulation of vascular smooth muscle cell proliferation |
| BP | IMP | GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway |
| BP | IDA | GO:2001258 | negative regulation of cation channel activity |
| BP | IMP | GO:2001268 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
Gene expression in normal tissue: MMP9
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MMP9
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP129 | Matrix Metalloproteinases |
| wikipathways | WP1434 | Osteopontin Signaling |
| wikipathways | WP1539 | Angiogenesis |
| wikipathways | WP1993 | Angiogenesis overview |
| wikipathways | WP2036 | TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway |
| wikipathways | WP2324 | AGE-RAGE pathway |
| wikipathways | WP2431 | Spinal Cord Injury |
| wikipathways | WP2815 | Mammary gland development pathway - Involution (Stage 4 of 4) |
| wikipathways | WP2865 | IL1 and megakaryocytes in obesity |
| wikipathways | WP3617 | Photodynamic therapy-induced NF-kB survival signaling |
| wikipathways | WP3624 | Lung fibrosis |
| wikipathways | WP4066 | Interleukin-4 and 13 signaling |
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
| wikipathways | WP474 | Endochondral Ossification |
| pid | amb2_neutrophils_pathway | amb2 Integrin signaling |
| pid | ap1_pathway | AP-1 transcription factor network |
| pid | avb3_opn_pathway | Osteopontin-mediated events |
| pid | betacatenin_nuc_pathway | Regulation of nuclear beta catenin signaling and target gene transcription |
| pid | cxcr4_pathway | CXCR4-mediated signaling events |
| pid | er_nongenomic_pathway | Plasma membrane estrogen receptor signaling |
| pid | fgf_pathway | FGF signaling pathway |
| pid | fra_pathway | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| pid | lysophospholipid_pathway | LPA receptor mediated events |
| pid | myc_activpathway | Validated targets of C-MYC transcriptional activation |
| pid | syndecan_1_pathway | Syndecan-1-mediated signaling events |
| pid | syndecan_4_pathway | Syndecan-4-mediated signaling events |
| pid | upa_upar_pathway | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| kegg | hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| kegg | hsa04670 | Leukocyte transendothelial migration - Homo sapiens (human) |
| kegg | hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| kegg | hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
| kegg | hsa05219 | Bladder cancer - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
| pharmgkb | PA152241951 | Celecoxib Pathway, Pharmacodynamics |
| biocarta | reckpathway | inhibition of matrix metalloproteinases |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1433557 | Signaling by SCF-KIT |
| reactome | R-HSA-1442490 | Collagen degradation |
| reactome | R-HSA-1442490 | Collagen degradation |
| reactome | R-HSA-1474228 | Degradation of the extracellular matrix |
| reactome | R-HSA-1474228 | Degradation of the extracellular matrix |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1474290 | Collagen formation |
| reactome | R-HSA-1592389 | Activation of Matrix Metalloproteinases |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-3928665 | EPH-ephrin mediated repulsion of cells |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD837 | Bevacizumab | 1 |
| iGMDRD562 | Navitoclax | 1 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD486 | Tosedostat | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD772 | BRD4770 | 1 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD226 | ML006 | 3 |
| iGMDRD267 | Oligomycin A | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MMP9
CLASSFICATION
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