MYBL2
Summary: The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| MYB proto-oncogene like 2 | MIM:601415 | Ensembl:ENSG00000101057 | HGNC:HGNC:7548 | PA31348 | 20q13.12 |
Gene Categories:
TUMOR SUPPRESSORGO terms in MYBL2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0000278 | mitotic cell cycle |
| BP | TAS | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | IEA | GO:0043525 | positive regulation of neuron apoptotic process |
| BP | IBA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0051726 | regulation of cell cycle |
| BP | IEA | GO:1990830 | cellular response to leukemia inhibitory factor |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0031523 | Myb complex |
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: MYBL2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MYBL2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 |
| reactome | R-HSA-1538133 | G0 and Early G1 |
| reactome | R-HSA-156711 | Polo-like kinase mediated events |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors |
| reactome | R-HSA-8869496 | TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| pid | e2f_pathway | E2F transcription factor network |
| wikipathways | WP1858 | Mitotic G1-G1-S phases |
| wikipathways | WP2361 | Gastric Cancer Network 1 |
| wikipathways | WP4086 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD883 | CIL55A | 1 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD61 | Kinetin riboside | 4 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD270 | Ciclosporin | 3 |
| iGMDRD554 | CHEMBL1434137 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MYBL2
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.