IL17RD
Summary: This gene encodes a membrane protein belonging to the interleukin-17 receptor (IL-17R) protein family. The encoded protein is a component of the interleukin-17 receptor signaling complex, and the interaction between this protein and IL-17R does not require the interleukin. The gene product also affects fibroblast growth factor signaling, inhibiting or stimulating growth through MAPK/ERK signaling. Alternate splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:606807 Ensembl IDEnsembl:ENSG00000144730 HGNC IDHGNC:HGNC:17616 PHARMGKB IDPA134993407 Map Location3p14.3 | |||||
GO terms in IL17RD
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0000139 | Golgi membrane |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005794 | Golgi apparatus |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0019221 | cytokine-mediated signaling pathway |
| MF | IBA | GO:0030368 | interleukin-17 receptor activity |
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Gene expression in normal tissue: IL17RD
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IL17RD
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_EGFR1 | EGFR1 |
| pid | fgf_pathway | FGF signaling pathway |
| wikipathways | WP2112 | IL17 signaling pathway |
| wikipathways | WP3651 | Pathways Affected in Adenoid Cystic Carcinoma |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IL17RD
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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