IL17RD
Summary: This gene encodes a membrane protein belonging to the interleukin-17 receptor (IL-17R) protein family. The encoded protein is a component of the interleukin-17 receptor signaling complex, and the interaction between this protein and IL-17R does not require the interleukin. The gene product also affects fibroblast growth factor signaling, inhibiting or stimulating growth through MAPK/ERK signaling. Alternate splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| interleukin 17 receptor D | MIM:606807 | Ensembl:ENSG00000144730 | HGNC:HGNC:17616 | PA134993407 | 3p14.3 |
GO terms in IL17RD
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0000139 | Golgi membrane |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005794 | Golgi apparatus |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0019221 | cytokine-mediated signaling pathway |
| MF | IBA | GO:0030368 | interleukin-17 receptor activity |
Gene expression in normal tissue: IL17RD
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IL17RD
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_EGFR1 | EGFR1 |
| pid | fgf_pathway | FGF signaling pathway |
| wikipathways | WP2112 | IL17 signaling pathway |
| wikipathways | WP3651 | Pathways Affected in Adenoid Cystic Carcinoma |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5674135 | MAP2K and MAPK activation |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD297 | Austocystin D | 6 |
| iGMDRD211 | (1S,3R)-RSL3 | 4 |
| iGMDRD123 | Isoevodiamine | 6 |
| iGMDRD584 | VER 155008 | 2 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD433 | Lexibulin | 3 |
| iGMDRD670 | ML 210 | 5 |
| iGMDRD888 | Compound 44 | 6 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD366 | PI-103 | 4 |
| iGMDRD871 | BRD6368 | 5 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD60 | Quinoclamine | 5 |
| iGMDRD64 | Parbendazole | 9 |
| iGMDRD260 | FQI-2 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IL17RD
CLASSFICATION
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