FOXO4

Summary: This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameforkhead box O4
OMIM IDMIM:300033
Ensembl IDEnsembl:ENSG00000184481
HGNC IDHGNC:HGNC:7139
PHARMGKB IDPA162388882
Map LocationXq13.1

GO terms in FOXO4


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IBA GO:0000122 negative regulation of transcription by RNA polymerase II
BP IDA GO:0006355 regulation of transcription, DNA-templated
BP TAS GO:0006366 transcription by RNA polymerase II
BP IDA GO:0007050 cell cycle arrest
BP IEA GO:0007095 mitotic G2 DNA damage checkpoint
BP IEA GO:0007517 muscle organ development
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Gene expression in normal tissue: FOXO4

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 30BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 4LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 3UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 2OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 2

Gene-drug pathway distribution

undefined12Metabolism1Mitosis1Apoptosis regulation1Proteasome1Ferroptosis1Longevity regulating pathway1

Pathways in FOXO4


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Database
Pathway ID
Pathway Des.
biocarta aktpathway akt signaling pathway
biocarta raspathway ras signaling pathway
reactome R-HSA-1257604 PIP3 activates AKT signaling
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-1643685 Disease
reactome R-HSA-198693 AKT phosphorylates targets in the nucleus
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD781 Sirolimus 1
iGMDRD494 Neopeltolide 2
iGMDRD424 Tamatinib 2
iGMDRD512 nutlin 3 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FOXO4

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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