NUP210

Summary: The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a membrane-spanning glycoprotein that is a major component of the nuclear pore complex. Multiple pseudogenes related to this gene are located on chromosome 3. [provided by RefSeq, Jul 2013].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namenucleoporin 210
OMIM IDMIM:607703
Ensembl IDEnsembl:ENSG00000132182
HGNC IDHGNC:HGNC:30052
PHARMGKB IDPA128394614
Map Location3p25.1

Gene Categories:

DRUGGABLE GENOME

GO terms in NUP210


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Term Type
Evidence Type
GO Term ID
GO Des.
CC TAS GO:0005635 nuclear envelope
CC IBA GO:0005643 nuclear pore
CC IEA GO:0005643 nuclear pore
CC IEA GO:0005789 endoplasmic reticulum membrane
CC HDA GO:0016020 membrane
CC IEA GO:0016021 integral component of membrane
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Gene expression in normal tissue: NUP210

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 34LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 36BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 12

Gene-drug pathway distribution

undefined23Apoptosis regulation1Metabolism1Mitosis1IGFR signaling1

Pathways in NUP210


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Database
Pathway ID
Pathway Des.
pid hdac_classi_pathway Signaling events mediated by HDAC Class I
pid hdac_classii_pathway Signaling events mediated by HDAC Class II
pid ranbp2pathway Sumoylation by RanBP2 regulates transcriptional repression
kegg hsa03013 RNA transport - Homo sapiens (human)
reactome R-HSA-1169408 ISG15 antiviral mechanism
reactome R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD341 Triacsin c 2
iGMDRD446 LY 2183240 5
iGMDRD698 Neratinib 3
iGMDRD237 ABT-751 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NUP210

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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