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PI4K2A

Summary: Phosphatidylinositolpolyphosphates (PtdInsPs) are centrally involved in many biologic processes, ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4KII phosphorylates PtdIns at the D-4 position, an essential step in the biosynthesis of PtdInsPs (Barylko et al., 2001 [PubMed 11244087]).[supplied by OMIM, Mar 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
phosphatidylinositol 4-kinase type 2 alpha	MIM:609763	Ensembl:ENSG00000155252	HGNC:HGNC:30031	PA162399304	10q24.2

Gene Categories:

DRUGGABLE GENOME PHOSPHATIDYLINOSITOL 3 KINASE KINASE

GO terms in PI4K2A

Term Type	Evidence Type	GO Term ID	GO Des.
CC	ISS	GO:0005739	mitochondrion
CC	HDA	GO:0005765	lysosomal membrane
CC	IBA	GO:0005768	endosome
CC	ISS	GO:0005768	endosome
CC	IBA	GO:0005802	trans-Golgi network
CC	TAS	GO:0005829	cytosol
CC	IBA	GO:0005886	plasma membrane
CC	IDA	GO:0005887	integral component of plasma membrane
CC	HDA	GO:0016020	membrane
CC	IEA	GO:0030054	cell junction
CC	ISS	GO:0030425	dendrite
CC	IEA	GO:0030672	synaptic vesicle membrane
CC	IDA	GO:0031083	BLOC-1 complex
CC	IDA	GO:0031224	intrinsic component of membrane
CC	ISS	GO:0031410	cytoplasmic vesicle
CC	IEA	GO:0031901	early endosome membrane
CC	ISS	GO:0035838	growing cell tip
CC	ISS	GO:0042734	presynaptic membrane
CC	ISS	GO:0043005	neuron projection
CC	ISS	GO:0043025	neuronal cell body
CC	IEA	GO:0043204	perikaryon
CC	ISS	GO:0044231	host cell presynaptic membrane
CC	IDA	GO:0045121	membrane raft
BP	IEA	GO:0002561	basophil degranulation
BP	IDA	GO:0006661	phosphatidylinositol biosynthetic process
BP	TAS	GO:0006661	phosphatidylinositol biosynthetic process
BP	IBA	GO:0007030	Golgi organization
BP	IBA	GO:0007032	endosome organization
BP	IBA	GO:0046854	phosphatidylinositol phosphorylation
BP	IDA	GO:0046854	phosphatidylinositol phosphorylation
MF	NAS	GO:0000287	magnesium ion binding
MF	IBA	GO:0004430	1-phosphatidylinositol 4-kinase activity
MF	IDA	GO:0004430	1-phosphatidylinositol 4-kinase activity
MF	TAS	GO:0004430	1-phosphatidylinositol 4-kinase activity
MF	IPI	GO:0005515	protein binding
MF	IDA	GO:0005524	ATP binding
MF	IDA	GO:0035651	AP-3 adaptor complex binding

Gene expression in normal tissue: PI4K2A

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PI4K2A

Database	Pathway ID	Pathway Des.
wikipathways	WP2203	Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway
wikipathways	WP363	Wnt Signaling Pathway
humancyc	PWY-6351	D-myo-inositol (1,4,5)-trisphosphate biosynthesis
humancyc	PWY-6352	3-phosphoinositide biosynthesis
humancyc	PWY-6371	superpathway of inositol phosphate compounds
pid	wnt_canonical_pathway	Canonical Wnt signaling pathway
kegg	hsa00562	Inositol phosphate metabolism - Homo sapiens (human)
kegg	hsa04070	Phosphatidylinositol signaling system - Homo sapiens (human)
reactome	R-HSA-1430728	Metabolism
reactome	R-HSA-1483255	PI Metabolism
reactome	R-HSA-1483257	Phospholipid metabolism
reactome	R-HSA-1660499	Synthesis of PIPs at the plasma membrane
reactome	R-HSA-1660514	Synthesis of PIPs at the Golgi membrane
reactome	R-HSA-1660516	Synthesis of PIPs at the early endosome membrane
reactome	R-HSA-556833	Metabolism of lipids

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD121	GMX1778	3
iGMDRD781	Sirolimus	3
iGMDRD267	Oligomycin A	6
iGMDRD494	Neopeltolide	6
iGMDRD434	BMS-536924	2
iGMDRD782	DC-45-A2	4
iGMDRD780	PP-30	2
iGMDRD506	Fedratinib	1
iGMDRD888	Compound 44	6
iGMDRD322	FK 866	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PI4K2A

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DATATYPES

CLASSFICATION

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