PI4K2A

Summary: Phosphatidylinositolpolyphosphates (PtdInsPs) are centrally involved in many biologic processes, ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4KII phosphorylates PtdIns at the D-4 position, an essential step in the biosynthesis of PtdInsPs (Barylko et al., 2001 [PubMed 11244087]).[supplied by OMIM, Mar 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namephosphatidylinositol 4-kinase type 2 alpha
OMIM IDMIM:609763
Ensembl IDEnsembl:ENSG00000155252
HGNC IDHGNC:HGNC:30031
PHARMGKB IDPA162399304
Map Location10q24.2

GO terms in PI4K2A


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Term Type
Evidence Type
GO Term ID
GO Des.
CC ISS GO:0005739 mitochondrion
CC HDA GO:0005765 lysosomal membrane
CC IBA GO:0005768 endosome
CC ISS GO:0005768 endosome
CC IBA GO:0005802 trans-Golgi network
CC TAS GO:0005829 cytosol
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Gene expression in normal tissue: PI4K2A

Gene-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 15undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 21

Gene-drug pathway distribution

undefined7Metabolism1Longevity regulating pathway1Other, kinases1

Pathways in PI4K2A


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Database
Pathway ID
Pathway Des.
wikipathways WP2203 Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway
wikipathways WP363 Wnt Signaling Pathway
humancyc PWY-6351 D-myo-inositol (1,4,5)-trisphosphate biosynthesis
humancyc PWY-6352 3-phosphoinositide biosynthesis
humancyc PWY-6371 superpathway of inositol phosphate compounds
pid wnt_canonical_pathway Canonical Wnt signaling pathway
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD121 GMX1778 3
iGMDRD781 Sirolimus 3
iGMDRD267 Oligomycin A 6
iGMDRD494 Neopeltolide 6
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PI4K2A

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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