TNNI3K
Summary: This gene encodes a protein that belongs to the MAP kinase kinase kinase (MAPKKK) family of protein kinases. The protein contains ankyrin repeat, protein kinase and serine-rich domains and is thought to play a role in cardiac physiology. [provided by RefSeq, Sep 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TNNI3 interacting kinase | MIM:613932 | Ensembl:ENSG00000116783 | HGNC:HGNC:19661 | PA134976654 | 1p31.1 |
GO terms in TNNI3K
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | IEA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0008022 | protein C-terminus binding |
| MF | IPI | GO:0031013 | troponin I binding |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | IGI | GO:0002027 | regulation of heart rate |
| BP | IMP | GO:0002027 | regulation of heart rate |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IMP | GO:0055117 | regulation of cardiac muscle contraction |
| BP | IMP | GO:0086069 | bundle of His cell to Purkinje myocyte communication |
| BP | IGI | GO:1903779 | regulation of cardiac conduction |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
Gene expression in normal tissue: TNNI3K
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TNNI3K
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD414 | MST-312 | 1 |
| iGMDRD872 | BRD7137 | 1 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD60 | Quinoclamine | 4 |
| iGMDRD270 | Ciclosporin | 2 |
| iGMDRD513 | BML-259 | 4 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD154 | NSC23766 | 1 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 2 |
| iGMDRD177 | Teniposide | 4 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD330 | BRD4132 | 2 |
| iGMDRD494 | Neopeltolide | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TNNI3K
CLASSFICATION
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