CSNK1G1
Summary: This gene encodes a member of the casein kinase I gene family. This family is comprised of serine/threonine kinases that phosphorylate acidic proteins such as caseins. The encoded kinase plays a role in cell cycle checkpoint arrest in response to stalled replication forks by phosphorylating Claspin. A mutation in this gene may be associated with non-syndromic early-onset epilepsy (NSEOE). [provided by RefSeq, Jul 2016].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:606274 Ensembl IDEnsembl:ENSG00000169118 HGNC IDHGNC:HGNC:2454 PHARMGKB IDPA26954 Map Location15q22.31 | |||||
GO terms in CSNK1G1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0006897 | endocytosis |
| BP | IBA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IDA | GO:0018105 | peptidyl-serine phosphorylation |
| CC | IBA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
Gene expression in normal tissue: CSNK1G1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CSNK1G1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04340 | Hedgehog signaling pathway - Homo sapiens (human) |
| pid | foxopathway | FoxO family signaling |
| pid | hedgehog_glipathway | Hedgehog signaling events mediated by Gli proteins |
| pid | p53regulationpathway | p53 pathway |
| pid | wnt_canonical_pathway | Canonical Wnt signaling pathway |
| wikipathways | WP363 | Wnt Signaling Pathway |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CSNK1G1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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