GRK2


Summary: This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease. [provided by RefSeq, Sep 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
G protein-coupled receptor kinase 2MIM:109635Ensembl:ENSG00000173020HGNC:HGNC:289PA4011q13.2

GO terms in GRK2


Term TypeEvidence TypeGO Term IDGO Des.
BPISSGO:0002029desensitization of G-protein coupled receptor protein signaling pathway
BPIMPGO:0003108negative regulation of the force of heart contraction by chemical signal
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPISSGO:0007213G-protein coupled acetylcholine receptor signaling pathway
BPIDAGO:0007217tachykinin receptor signaling pathway
BPIEAGO:0007507heart development
BPISSGO:0018105peptidyl-serine phosphorylation
BPIEAGO:0018107peptidyl-threonine phosphorylation
BPIMPGO:0019079viral genome replication
BPIDAGO:0031623receptor internalization
BPISSGO:0033605positive regulation of catecholamine secretion
BPIMPGO:0045988negative regulation of striated muscle contraction
BPIMPGO:0046718viral entry into host cell
BPIMPGO:0060048cardiac muscle contraction
CCIDAGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCTASGO:0005886plasma membrane
CCTASGO:0005929cilium
CCHDAGO:0016020membrane
CCISSGO:0016020membrane
MFISSGO:0004672protein kinase activity
MFISSGO:0004703G-protein coupled receptor kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFISSGO:0031694alpha-2A adrenergic receptor binding
MFIDAGO:0031755Edg-2 lysophosphatidic acid receptor binding
MFTASGO:0047696beta-adrenergic receptor kinase activity

Gene expression in normal tissue: GRK2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GRK2


DatabasePathway IDPathway Des.
biocartabarrestinpathway-arrestins in gpcr desensitization
biocartabarrestinsrcpathwayroles of arrestin dependent recruitment of src kinases in gpcr signaling
biocartabarrmapkpathwayrole of -arrestins in the activation and targeting of map kinases
biocartack1pathwayregulation of ck1/cdk5 by type 1 glutamate receptors
reactomeR-HSA-111885Opioid Signalling
reactomeR-HSA-111933Calmodulin induced events
reactomeR-HSA-111996Ca-dependent events
reactomeR-HSA-111997CaM pathway
reactomeR-HSA-112040G-protein mediated events
reactomeR-HSA-112043PLC beta mediated events
reactomeR-HSA-1489509DAG and IP3 signaling
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-416476G alpha (q) signalling events
reactomeR-HSA-418555G alpha (s) signalling events
reactomeR-HSA-418594G alpha (i) signalling events
reactomeR-HSA-5358351Signaling by Hedgehog
reactomeR-HSA-5358351Signaling by Hedgehog
reactomeR-HSA-5632684Hedgehog 'on' state
reactomeR-HSA-5632684Hedgehog 'on' state
reactomeR-HSA-5635838Activation of SMO
reactomeR-HSA-5635838Activation of SMO
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-8856825Cargo recognition for clathrin-mediated endocytosis
reactomeR-HSA-8856828Clathrin-mediated endocytosis
reactomeR-HSA-9006925Intracellular signaling by second messengers
wikipathwaysWP3929Chemokine signaling pathway
wikipathwaysWP4249Hedgehog Signaling Pathway
wikipathwaysWP47Hedgehog Signaling Pathway
pidcxcr4_pathwayCXCR4-mediated signaling events
pidhdac_classii_pathwaySignaling events mediated by HDAC Class II
pidhedgehog_2pathwaySignaling events mediated by the Hedgehog family
pidil8cxcr1_pathwayIL8- and CXCR1-mediated signaling events
pidtxa2pathwayThromboxane A2 receptor signaling
pharmgkbPA165984799Diuretics Pathway, Pharmacodynamics
pharmgkbPA2024Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa04144Endocytosis - Homo sapiens (human)
kegghsa04340Hedgehog signaling pathway - Homo sapiens (human)
kegghsa04724Glutamatergic synapse - Homo sapiens (human)
kegghsa04740Olfactory transduction - Homo sapiens (human)
kegghsa05032Morphine addiction - Homo sapiens (human)
netpathPathway_EGFR1EGFR1
netpathPathway_HedgehogHedgehog

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD286Nsc 6328393
iGMDRD414MST-3123
iGMDRD152179324-69-73
iGMDRD237ABT-7513
iGMDRD577BIX012943
iGMDRD394BX-7952
iGMDRD280CYTOCHALASIN B6
iGMDRD945ML2142
iGMDRD158NSC1415402
iGMDRD271Brefeldin A1
iGMDRD512nutlin 33
iGMDRD105Triptolide6
iGMDRD289Parthenolide1
iGMDRD77Itraconazole3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GRK2

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