GRK2
Summary: This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease. [provided by RefSeq, Sep 2017].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:109635 Ensembl IDEnsembl:ENSG00000173020 HGNC IDHGNC:HGNC:289 PHARMGKB IDPA40 Map Location11q13.2 | |||||
GO terms in GRK2
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ISS | GO:0002029 | desensitization of G-protein coupled receptor protein signaling pathway |
| BP | IMP | GO:0003108 | negative regulation of the force of heart contraction by chemical signal |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | ISS | GO:0007213 | G-protein coupled acetylcholine receptor signaling pathway |
| BP | IDA | GO:0007217 | tachykinin receptor signaling pathway |
| BP | IEA | GO:0007507 | heart development |
Gene expression in normal tissue: GRK2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GRK2
Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | barrestinpathway | -arrestins in gpcr desensitization |
| biocarta | barrestinsrcpathway | roles of arrestin dependent recruitment of src kinases in gpcr signaling |
| biocarta | barrmapkpathway | role of -arrestins in the activation and targeting of map kinases |
| biocarta | ck1pathway | regulation of ck1/cdk5 by type 1 glutamate receptors |
| reactome | R-HSA-111885 | Opioid Signalling |
| reactome | R-HSA-111933 | Calmodulin induced events |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GRK2
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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