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Summary: In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq, Jul 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameguanine monophosphate synthase OMIM IDMIM:600358 Ensembl IDEnsembl:ENSG00000163655 HGNC IDHGNC:HGNC:4378 PHARMGKB IDPA28763 Map Location3q25.31

GO terms in GMPS

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IBA	GO:0003824	catalytic activity
MF	EXP	GO:0003921	GMP synthase activity
MF	IBA	GO:0003921	GMP synthase activity
MF	IBA	GO:0003922	GMP synthase (glutamine-hydrolyzing) activity
MF	IEA	GO:0005524	ATP binding
MF	IEA	GO:0016462	pyrophosphatase activity

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Gene expression in normal tissue: GMPS

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GMPS

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Database	Pathway ID	Pathway Des.
pharmgkb	PA2040	Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics
kegg	hsa00230	Purine metabolism - Homo sapiens (human)
kegg	hsa00983	Drug metabolism - other enzymes - Homo sapiens (human)
humancyc	PWY-7221	guanosine ribonucleotides de novo biosynthesis
humancyc	PWY-7228	guanosine nucleotides de novo biosynthesis
humancyc	PWY-841	purine nucleotides de novo biosynthesis

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD263	AACOCF3	3
iGMDRD188	Piperlongumine	3
iGMDRD398	Sepantronium	3
iGMDRD506	Fedratinib	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GMPS

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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