GMPS
Summary: In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| guanine monophosphate synthase | MIM:600358 | Ensembl:ENSG00000163655 | HGNC:HGNC:4378 | PA28763 | 3q25.31 |
GO terms in GMPS
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0003824 | catalytic activity |
| MF | EXP | GO:0003921 | GMP synthase activity |
| MF | IBA | GO:0003921 | GMP synthase activity |
| MF | IBA | GO:0003922 | GMP synthase (glutamine-hydrolyzing) activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0016462 | pyrophosphatase activity |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| BP | IBA | GO:0006177 | GMP biosynthetic process |
| BP | IEA | GO:0006177 | GMP biosynthetic process |
| BP | IEA | GO:0006541 | glutamine metabolic process |
| BP | TAS | GO:0009113 | purine nucleobase biosynthetic process |
| BP | TAS | GO:0009168 | purine ribonucleoside monophosphate biosynthetic process |
Gene expression in normal tissue: GMPS
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GMPS
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pharmgkb | PA2040 | Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics |
| kegg | hsa00230 | Purine metabolism - Homo sapiens (human) |
| kegg | hsa00983 | Drug metabolism - other enzymes - Homo sapiens (human) |
| humancyc | PWY-7221 | guanosine ribonucleotides de novo biosynthesis |
| humancyc | PWY-7228 | guanosine nucleotides de novo biosynthesis |
| humancyc | PWY-841 | purine nucleotides de novo biosynthesis |
| humancyc | PWY66-409 | superpathway of purine nucleotide salvage |
| smpdb | SMP00050 | Purine Metabolism |
| smpdb | SMP00072 | Glutamate Metabolism |
| smpdb | SMP00136 | 2-Hydroxyglutric Aciduria (D And L Form) |
| smpdb | SMP00144 | Adenosine Deaminase Deficiency |
| smpdb | SMP00167 | Adenylosuccinate Lyase Deficiency |
| smpdb | SMP00168 | AICA-Ribosiduria |
| smpdb | SMP00203 | Molybdenum Cofactor Deficiency |
| smpdb | SMP00210 | Purine Nucleoside Phosphorylase Deficiency |
| smpdb | SMP00220 | Xanthine Dehydrogenase Deficiency (Xanthinuria) |
| smpdb | SMP00243 | 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency |
| smpdb | SMP00339 | Hyperinsulinism-Hyperammonemia Syndrome |
| smpdb | SMP00364 | Lesch-Nyhan Syndrome (LNS) |
| smpdb | SMP00365 | Gout or Kelley-Seegmiller Syndrome |
| smpdb | SMP00385 | Homocarnosinosis |
| smpdb | SMP00427 | Azathioprine Action Pathway |
| smpdb | SMP00428 | Mercaptopurine Action Pathway |
| smpdb | SMP00430 | Thioguanine Action Pathway |
| smpdb | SMP00512 | Xanthinuria type I |
| smpdb | SMP00513 | Xanthinuria type II |
| smpdb | SMP00535 | Adenine phosphoribosyltransferase deficiency (APRT) |
| smpdb | SMP00536 | Mitochondrial DNA depletion syndrome |
| smpdb | SMP00537 | Myoadenylate deaminase deficiency |
| smpdb | SMP00567 | Succinic semialdehyde dehydrogenase deficiency |
| smpdb | SMP00609 | Mercaptopurine Metabolism Pathway |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-15869 | Metabolism of nucleotides |
| reactome | R-HSA-73817 | Purine ribonucleoside monophosphate biosynthesis |
| reactome | R-HSA-8956320 | Nucleobase biosynthesis |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD263 | AACOCF3 | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD251 | ML162 | 6 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 6 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD314 | Tanespimycin | 3 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD126 | Tipifarnib | 7 |
| iGMDRD599 | Salermide | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GMPS
CLASSFICATION
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