FFAR2
Summary: This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for short chain free fatty acids and may be involved in the inflammatory response and in regulating lipid plasma levels. [provided by RefSeq, Apr 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| free fatty acid receptor 2 | MIM:603823 | Ensembl:ENSG00000126262 | HGNC:HGNC:4501 | PA28890 | 19q13.12 |
GO terms in FFAR2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0042995 | cell projection |
| BP | ISS | GO:0002232 | leukocyte chemotaxis involved in inflammatory response |
| BP | ISS | GO:0002385 | mucosal immune response |
| BP | ISS | GO:0002673 | regulation of acute inflammatory response |
| BP | ISS | GO:0002720 | positive regulation of cytokine production involved in immune response |
| BP | IMP | GO:0002752 | cell surface pattern recognition receptor signaling pathway |
| BP | ISS | GO:0002879 | positive regulation of acute inflammatory response to non-antigenic stimulus |
| BP | IDA | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | ISS | GO:0019915 | lipid storage |
| BP | ISS | GO:0032722 | positive regulation of chemokine production |
| BP | ISS | GO:0042593 | glucose homeostasis |
| BP | ISS | GO:0045444 | fat cell differentiation |
| BP | IDA | GO:0071398 | cellular response to fatty acid |
| BP | ISS | GO:0090276 | regulation of peptide hormone secretion |
| BP | IMP | GO:2000484 | positive regulation of interleukin-8 secretion |
| MF | IDA | GO:0004930 | G-protein coupled receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008289 | lipid binding |
Gene expression in normal tissue: FFAR2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FFAR2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-416476 | G alpha (q) signalling events |
| reactome | R-HSA-444209 | Free fatty acid receptors |
| reactome | R-HSA-500792 | GPCR ligand binding |
| kegg | hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| wikipathways | WP4030 | SCFA and skeletal muscle substrate metabolism |
| wikipathways | WP455 | GPCRs, Class A Rhodopsin-like |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD506 | Fedratinib | 5 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD872 | BRD7137 | 5 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD441 | TW 37 | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD267 | Oligomycin A | 1 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD705 | Nakiterpiosin | 5 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FFAR2
CLASSFICATION
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