ULK4
Summary: This gene encodes a member of the unc-51-like serine/threonine kinase (STK) family. Members of this protein family play a role in neuronal growth and endocytosis. The encoded protein is likely involved in neurite branching, neurite elongation and neuronal migration. Genome-wide association studies (GWAS) indicate an association of variations in this gene with blood pressure and hypertension. Sequence variations in this gene may also be be associated with psychiatric disorders, including schizophrenia and bipolar disorder. Pseudogenes associated with this gene have been identified and are located on chromosome 15. [provided by RefSeq, Jul 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| unc-51 like kinase 4 | MIM:617010 | Ensembl:ENSG00000168038 | HGNC:HGNC:15784 | PA134978836 | 3p22.1 |
GO terms in ULK4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0000226 | microtubule cytoskeleton organization |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | IMP | GO:0010975 | regulation of neuron projection development |
| BP | IMP | GO:0043408 | regulation of MAPK cascade |
| BP | IMP | GO:0046328 | regulation of JNK cascade |
| BP | IMP | GO:0090036 | regulation of protein kinase C signaling |
| BP | IMP | GO:1900744 | regulation of p38MAPK cascade |
| BP | IMP | GO:2001222 | regulation of neuron migration |
| MF | IEA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IEA | GO:0005524 | ATP binding |
Gene expression in normal tissue: ULK4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ULK4
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD772 | BRD4770 | 1 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD351 | GW843682X | 4 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD152 | 179324-69-7 | 2 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD394 | BX-795 | 6 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD137 | Indisulam | 4 |
| iGMDRD227 | Fatostatin A | 4 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD870 | BRD63610 | 2 |
| iGMDRD399 | Selumetinib | 4 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD366 | PI-103 | 1 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD300 | Tozasertib | 4 |
| iGMDRD147 | Prima-1 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ULK4
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