STK36
Summary: This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| serine/threonine kinase 36 | MIM:607652 | Ensembl:ENSG00000163482 | HGNC:HGNC:17209 | PA38212 | 2q35 |
GO terms in STK36
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| BP | IEA | GO:0003351 | epithelial cilium movement |
| BP | TAS | GO:0006468 | protein phosphorylation |
| BP | ISS | GO:0007228 | positive regulation of hh target transcription factor activity |
| BP | IEA | GO:0007420 | brain development |
| BP | ISS | GO:0009791 | post-embryonic development |
| BP | ISS | GO:0045880 | positive regulation of smoothened signaling pathway |
| BP | IDA | GO:0051090 | regulation of DNA-binding transcription factor activity |
| BP | ISS | GO:0060271 | cilium assembly |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0005524 | ATP binding |
| MF | IDA | GO:0008134 | transcription factor binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: STK36
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in STK36
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_Hedgehog | Hedgehog |
| pid | hedgehog_glipathway | Hedgehog signaling events mediated by Gli proteins |
| wikipathways | WP47 | Hedgehog Signaling Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD398 | Sepantronium | 1 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD246 | NPC26 | 1 |
| iGMDRD883 | CIL55A | 1 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD512 | nutlin 3 | 4 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD248 | BRD4354 | 3 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD483 | SCH-529074 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in STK36
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