STK36


Summary: This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
serine/threonine kinase 36MIM:607652Ensembl:ENSG00000163482HGNC:HGNC:17209PA382122q35

GO terms in STK36


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005634nucleus
CCIDAGO:0005737cytoplasm
CCIDAGO:0005829cytosol
BPIEAGO:0003351epithelial cilium movement
BPTASGO:0006468protein phosphorylation
BPISSGO:0007228positive regulation of hh target transcription factor activity
BPIEAGO:0007420brain development
BPISSGO:0009791post-embryonic development
BPISSGO:0045880positive regulation of smoothened signaling pathway
BPIDAGO:0051090regulation of DNA-binding transcription factor activity
BPISSGO:0060271cilium assembly
MFTASGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFTASGO:0005524ATP binding
MFIDAGO:0008134transcription factor binding
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: STK36

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in STK36


DatabasePathway IDPathway Des.
netpathPathway_HedgehogHedgehog
pidhedgehog_glipathwayHedgehog signaling events mediated by Gli proteins
wikipathwaysWP47Hedgehog Signaling Pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD871BRD63682
iGMDRD398Sepantronium1
iGMDRD152179324-69-73
iGMDRD60Quinoclamine3
iGMDRD246NPC261
iGMDRD883CIL55A1
iGMDRD126Tipifarnib4
iGMDRD202Curcumin3
iGMDRD512nutlin 34
iGMDRD599Salermide3
iGMDRD248BRD43543
iGMDRD560MK-22063
iGMDRD483SCH-5290743

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in STK36

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