STK36
Summary: This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:607652 Ensembl IDEnsembl:ENSG00000163482 HGNC IDHGNC:HGNC:17209 PHARMGKB IDPA38212 Map Location2q35 | |||||
GO terms in STK36
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| BP | IEA | GO:0003351 | epithelial cilium movement |
| BP | TAS | GO:0006468 | protein phosphorylation |
| BP | ISS | GO:0007228 | positive regulation of hh target transcription factor activity |
Gene expression in normal tissue: STK36
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in STK36
Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_Hedgehog | Hedgehog |
| pid | hedgehog_glipathway | Hedgehog signaling events mediated by Gli proteins |
| wikipathways | WP47 | Hedgehog Signaling Pathway |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in STK36
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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